Stable Colloids of Paclitaxel Nanoparticles Coated with PEGylated Polyelectrolyte Shells
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ABSTRACTA novel nanoparticulated form of the poorly water-soluble anticancer drug paclitaxel (PTX) suitable for intravenous administration has been developed using sonication-assisted layer-by-layer (LbL) assembly. The nanoparticles contain up to 70 wt.% of the drug and consist of 150-180 nm solid crystal paclitaxel cores coated with 20-30 nm thick shells of alternative layers of PEGylated poly-L-lysine and heparin. Dispersions of PTX nanoparticles are stable in different biological solvents at concentrations up to 5 mg/ml. Intravenous administration of the LbL-coated nano-crystalline PTX to mice via tail injection provided the preliminary confirmation of their safety and tolerability.
2011 ◽
Vol 236-238
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pp. 1103-1106
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2014 ◽
Vol 32
(4)
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pp. 1451-1461
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2010 ◽
Vol 40
(1)
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pp. 48-55
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2010 ◽
Vol 389
(1-2)
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pp. 244-253
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2018 ◽
Vol 169
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pp. 265-272
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2015 ◽
Vol 3
(7)
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pp. 1391-1404
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