Electron induced single strand break and cyclization: a DFT study on the radiosensitization mechanism of the nucleotide of 8-bromoguanine

2014 ◽  
Vol 16 (14) ◽  
pp. 6568-6574 ◽  
Author(s):  
Lidia Chomicz ◽  
Al'ona Furmanchuk ◽  
Jerzy Leszczynski ◽  
Janusz Rak
Keyword(s):  
Electron Attachment ◽  
Strand Break ◽  
Single Strand ◽  
Dft Study ◽  
Single Strand Break ◽  
Phosphodiester Bond ◽  
Bond Breakage

The radiosensitization mechanism of 8-bromoguanosine is studied on its 3′,5′-diphosphate. Electron attachment to the nucleotide results in phosphodiester bond breakage or the 5′,8-cycloguanosine lesion.

Effects of Singlet Oxygen on the Biological Activity of DNA and Its Involvement in Single Strand-Break Formation

1988 ◽  
pp. 473-477
Author(s):  
Heribert Wefers ◽  
Paolo Di Mascio ◽  
Hong-Phuc Do-Thi ◽  
Dietrich Schulte-Frohlinde ◽  
Helmut Sies
Keyword(s):  
Biological Activity ◽  
Singlet Oxygen ◽  
Strand Break ◽  
Single Strand ◽  
Single Strand Break ◽  
Break Formation

End-damage-specific proteins facilitate recruitment or stability of X-ray cross-complementing protein 1 at the sites of DNA single-strand break repair

FEBS Journal ◽  
2005 ◽  
Vol 272 (22) ◽  
pp. 5753-5763 ◽  
Author(s):  
Jason L. Parsons ◽  
Irina I. Dianova ◽  
Emma Boswell ◽  
Michael Weinfeld ◽  
Grigory L. Dianov
Keyword(s):  
Strand Break ◽  
Single Strand ◽  
Single Strand Break ◽  
X Ray ◽  
Single Strand Break Repair ◽  
Specific Proteins ◽  
Break Repair

scholarly journals Single-Strand Break End Resection in Genome Integrity: Mechanism and Regulation by APE2

2018 ◽  
Vol 19 (8) ◽  
pp. 2389 ◽  
Author(s):  
Md. Hossain ◽  
Yunfeng Lin ◽  
Shan Yan
Keyword(s):  
Dna Damage ◽  
Genome Instability ◽  
Strand Break ◽  
Single Strand ◽  
Genome Integrity ◽  
Single Strand Break ◽  
Strand Breaks ◽  
Single Strand Breaks ◽  
Damage Response ◽  
End Resection

DNA single-strand breaks (SSBs) occur more than 10,000 times per mammalian cell each day, representing the most common type of DNA damage. Unrepaired SSBs compromise DNA replication and transcription programs, leading to genome instability. Unrepaired SSBs are associated with diseases such as cancer and neurodegenerative disorders. Although canonical SSB repair pathway is activated to repair most SSBs, it remains unclear whether and how unrepaired SSBs are sensed and signaled. In this review, we propose a new concept of SSB end resection for genome integrity. We propose a four-step mechanism of SSB end resection: SSB end sensing and processing, as well as initiation, continuation, and termination of SSB end resection. We also compare different mechanisms of SSB end resection and DSB end resection in DNA repair and DNA damage response (DDR) pathways. We further discuss how SSB end resection contributes to SSB signaling and repair. We focus on the mechanism and regulation by APE2 in SSB end resection in genome integrity. Finally, we identify areas of future study that may help us gain further mechanistic insight into the process of SSB end resection. Overall, this review provides the first comprehensive perspective on SSB end resection in genome integrity.

scholarly journals APE2 promotes DNA damage response pathway from a single-strand break

2018 ◽  
Vol 46 (5) ◽  
pp. 2479-2494 ◽  
Author(s):  
Yunfeng Lin ◽  
Liping Bai ◽  
Steven Cupello ◽  
Md Akram Hossain ◽  
Bradley Deem ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Strand Break ◽  
Single Strand ◽  
Single Strand Break ◽  
Damage Response ◽  
Dna Damage Response Pathway

scholarly journals Computational Studies of the Mechanical Stability for Single-Strand Break DNA

2018 ◽  
Vol 122 (34) ◽  
pp. 8166-8173 ◽  
Author(s):  
Paweł Krupa ◽  
David J. Wales ◽  
Adam K. Sieradzan
Keyword(s):  
Mechanical Stability ◽  
Strand Break ◽  
Single Strand ◽  
Computational Studies ◽  
Single Strand Break

scholarly journals Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1

Cell Reports ◽  
2019 ◽  
Vol 26 (3) ◽  
pp. 573-581.e5 ◽  
Author(s):  
Luis M. Polo ◽  
Yingqi Xu ◽  
Peter Hornyak ◽  
Fernando Garces ◽  
Zhihong Zeng ◽  
...  
Keyword(s):  
Strand Break ◽  
Single Strand ◽  
Brct Domain ◽  
Single Strand Break ◽  
Single Strand Break Repair ◽  
Break Repair
Sign in / Sign up

Export Citation Format

Share Document