Live cell imaging in a micro-array of acoustic traps facilitates quantification of natural killer cell heterogeneity

2013 ◽  
Vol 5 (4) ◽  
pp. 712-719 ◽  
Author(s):  
Athanasia E. Christakou ◽  
Mathias Ohlin ◽  
Bruno Vanherberghen ◽  
Mohammad Ali Khorshidi ◽  
Nadir Kadri ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Killer Cell ◽  
Live Cell ◽  
Cell Heterogeneity ◽  
Micro Array

scholarly journals Natural killer cell granules converge to avoid collateral damage

2016 ◽  
Vol 215 (6) ◽  
pp. 765-767 ◽  
Author(s):  
Alex T. Ritter ◽  
Ira Mellman
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Killer Cell ◽  
Target Cells ◽  
Cytotoxic Lymphocytes ◽  
Collateral Damage ◽  
Polarized Secretion ◽  
Lytic Granule

To clear infection, cytotoxic lymphocytes must destroy target cells while avoiding nonspecific killing of surrounding healthy cells. In this issue, Hsu et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201604136) use live-cell imaging to show that lytic granule convergence protects bystander cells from unintended death by promoting polarized secretion of soluble cytolytic proteins toward the intended target.

scholarly journals Live Cell Linear Dichroism Imaging Reveals Extensive Membrane Ruffling within the Docking Structure of Natural Killer Cell Immune Synapses

2009 ◽  
Vol 96 (2) ◽  
pp. L13-L15 ◽  
Author(s):  
Richard K.P. Benninger ◽  
Bruno Vanherberghen ◽  
Stephen Young ◽  
Sabrina B. Taner ◽  
Fiona J. Culley ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Linear Dichroism ◽  
Live Cell ◽  
Membrane Ruffling ◽  
Immune Synapses

Natural killer cell heterogeneity: cellular dysfunction and significance in HIV-1 immuno-pathogenesis

2015 ◽  
Vol 72 (16) ◽  
pp. 3037-3049 ◽  
Author(s):  
A. Wahid Ansari ◽  
Fareed Ahmad ◽  
Dirk Meyer-Olson ◽  
Adeeba Kamarulzaman ◽  
Roland Jacobs ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Cell Heterogeneity ◽  
Cellular Dysfunction ◽  
Hiv 1
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