Development of PEGylated KMnF3 nanoparticles as a T1-weighted contrast agent: chemical synthesis, in vivo brain MR imaging, and accounting for high relaxivity

Nanoscale ◽  
2013 ◽  
Vol 5 (11) ◽  
pp. 5073 ◽  
Author(s):  
Zhi-jun Liu ◽  
Xiao-xia Song ◽  
Qun Tang
Keyword(s):  
Mr Imaging ◽  
Chemical Synthesis ◽  
Contrast Agent ◽  
High Relaxivity

Liquid oral magnetic particles as a gastrointestinal contrast agent for MR imaging: Efficacy in vivo

1993 ◽  
Vol 3 (1) ◽  
pp. 113-118 ◽  
Author(s):  
Daniel L Rubin ◽  
Holde H. Muller ◽  
Manrita K. Sidhu ◽  
Stuart W. Young ◽  
William A. Hunke ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Contrast Agent ◽  
Magnetic Particles

Ultra-high relaxivity iron oxide nanoparticles confined in polymer nanospheres for tumor MR imaging

2015 ◽  
Vol 3 (28) ◽  
pp. 5702-5710 ◽  
Author(s):  
Ying Lin ◽  
Sanxi Wang ◽  
Yajun Zhang ◽  
Jiangang Gao ◽  
Liu Hong ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Contrast Agent ◽  
Iron Oxide Nanoparticles ◽  
Mri Contrast Agent ◽  
Oxide Nanoparticles ◽  
Hydrophilic Polymer ◽  
Mri Contrast ◽  
High Relaxivity ◽  
Polymer Nanospheres

An ultra-high relaxivity of MRI contrast agent was fabricated by controlling the clustering of iron oxide nanoparticles confined in a hydrophilic polymer.

scholarly journals Uniform Fe3O4/Gd2O3-DHCA nanocubes for dual-mode MR imaging

2020 ◽  
Author(s):  
Miao Qin ◽  
Yueyou Peng ◽  
Mengjie Xu ◽  
Hui Yan ◽  
Yizhu Cheng ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Mr Imaging ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Clinical Diagnosis ◽  
Multimodal Imaging ◽  
Experimental Results ◽  
Dual Mode ◽  
3.0 T

Multimodal imaging technology were extensively studied over past few years, because they offered complementary diagnosis information, which can increase the accuracy of diagnosis. The synthesis of contrast agents via simplified methods are desired for the development of multimodal imaging. Herein, uniformly distributed Fe3O4/Gd2O3 nanocubes for T1-T2 dual-mode contrast agents were rationally designed and successfully fabricated by our group. In this system, the Fe3O4/Gd2O3 nanocubes were coated with nontoxic 3,4-dihydroxyhydrocinnamic acid (DHCA) for better hydrophilia and biocompatibility. The results show that Ferrum (Fe) and Gadolinium (Gd) elements are homo-dispersity in the Fe3O4/Gd2O3-DHCA (FGDA) nanocubes. Relaxivity study at 3.0 T scanner demonstrates that the r1 value and r2 value of FGDA nanocubes reach up to 67.57 ± 6.2 mM-1s-1 and 24.2 ± 1.46 mM-1s-1. The images of T1-weighted and T2-weighted imaging in vivo demonstrate that FGDA nanocubes possess the ability of magnetic resonance (MR) imaging enhancement as dual-mode contrast agent. The above illustrated experimental results indicate that FGDA nanocubes can be applied in clinical diagnosis in future.

In vivo CEST MR imaging of U87 mice brain tumor angiogenesis using targeted LipoCEST contrast agent at 7 T

2012 ◽  
Vol 69 (1) ◽  
pp. 179-187 ◽  
Author(s):  
Julien Flament ◽  
Françoise Geffroy ◽  
Christelle Medina ◽  
Caroline Robic ◽  
Jean-François Mayer ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Mr Imaging ◽  
Contrast Agent ◽  
Tumor Angiogenesis ◽  
Mice Brain

Synthesis, relaxation properties and in vivo assessment of a carborane-GdDOTA-monoamide conjugate as an MRI blood pool contrast agent

2015 ◽  
Vol 13 (33) ◽  
pp. 8912-8918 ◽  
Author(s):  
Lalit N. Goswami ◽  
Quanyu Cai ◽  
Lixin Ma ◽  
Satish S. Jalisatgi ◽  
M. Frederick Hawthorne
Keyword(s):  
Contrast Agent ◽  
Blood Pool ◽  
Blood Pool Contrast Agent ◽  
Relaxation Properties ◽  
High Relaxivity ◽  
In Vivo Assessment

The synthesis, relaxivity measurements and in vivo assessment of CB-GdDOTA-MA amphiphilic conjugate as blood pool contrast agent (BPCA) is reported. This BPCA showed high relaxivity (r1 = 6.8 mM−1 s−1 at 7 T in PBS) and exhibited excellent binding (87.4%) with HSA.

scholarly journals Hyperpolarized Water as an MR Imaging Contrast Agent: Feasibility of in Vivo Imaging in a Rat Model

Radiology ◽  
2012 ◽  
Vol 265 (2) ◽  
pp. 418-425 ◽  
Author(s):  
Mark D. Lingwood ◽  
Ting Ann Siaw ◽  
Napapon Sailasuta ◽  
Osama A. Abulseoud ◽  
Henry R. Chan ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Contrast Agent ◽  
Rat Model ◽  
In Vivo Imaging ◽  
Imaging Contrast Agent

Magnetic PEGylated Pt3Co nanoparticles as a novel MR contrast agent: in vivo MR imaging and long-term toxicity study

Nanoscale ◽  
2013 ◽  
Vol 5 (24) ◽  
pp. 12464 ◽  
Author(s):  
Shengnan Yin ◽  
Zhiwei Li ◽  
Liang Cheng ◽  
Chao Wang ◽  
Yumeng Liu ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Contrast Agent ◽  
Toxicity Study
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