Development and validation of a method for the determination of nicotinic acid in human plasma using liquid chromatography-negative electrospray ionization tandem mass spectrometry and its application to a bioequivalence study

2014 ◽  
Vol 6 (20) ◽  
pp. 8258-8267 ◽  
Author(s):  
Wei-Hua Huang ◽  
Kai Hu ◽  
Li Shao ◽  
Yao Chen ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Nicotinic Acid ◽  
Bioequivalence Study ◽  
Tandem Mass ◽  
Negative Electrospray Ionization ◽  
Development And Validation ◽  
Ionization Tandem Mass Spectrometry

For 60 years, nicotinic acid (NA) has been used as a potent vitamin in milligram doses while NA in gram doses has been administrated as a broad-spectrum lipid drug potent.

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