Highly sensitive methyltransferase activity assay and inhibitor screening based on fluorescence quenching of graphene oxide integrated with the site-specific cleavage of restriction endonuclease

2014 ◽  
Vol 50 (73) ◽  
pp. 10691-10694 ◽  
Author(s):  
Lijuan Ji ◽  
Zhewei Cai ◽  
Yingdan Qian ◽  
Ping Wu ◽  
Hui Zhang ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Fluorescence Quenching ◽  
Restriction Endonuclease ◽  
Dna Methyltransferase ◽  
Activity Assay ◽  
Methyltransferase Activity ◽  
Site Specific ◽  
Inhibitor Screening ◽  
Selective Approach ◽  
Highly Sensitive

A sensitive and selective approach for the DNA methyltransferase activity assay and MTase inhibitor screening is reported.

Immuno-DNA binding directed template-free DNA extension and enzyme catalysis for sensitive electrochemical DNA methyltransferase activity assay and inhibitor screening

The Analyst ◽  
2020 ◽  
Vol 145 (8) ◽  
pp. 3064-3072 ◽  
Author(s):  
Ying Zhang ◽  
Lijie Hao ◽  
Zhen Zhao ◽  
Xiaoyan Yang ◽  
Li Wang ◽  
...  
Keyword(s):  
Dna Binding ◽  
Enzyme Catalysis ◽  
Dna Methyltransferase ◽  
Dna Sensing ◽  
Activity Assay ◽  
Methyltransferase Activity ◽  
Inhibitor Screening ◽  
Free Dna ◽  
Sensing Platform ◽  
Template Free

A new electrochemical immuno-DNA sensing platform for DNA methyltransferase activity assay and inhibitor screening.

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