Enantioselective synthesis of arylglycine derivatives by direct C–H oxidative cross-coupling

A new method for the synthesis of chiral α-amino acid derivatives by enantioselective C–H arylation of N-aryl glycine esters with aryl boric acids by direct C–H oxidative cross-coupling has been performed. This work successfully integrates the direct C–H oxidation with asymmetric arylation and exhibits excellent enantioselectivity.

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An enantioselective synthesis of β2-amino acid derivatives

Tetrahedron Asymmetry ◽

10.1016/j.tetasy.2005.01.048 ◽

2005 ◽

Vol 16 (7) ◽

pp. 1309-1319 ◽

Cited By ~ 23

Author(s):

Jomana Elaridi ◽

Ali Thaqi ◽

Andrew Prosser ◽

W. Roy Jackson ◽

Andrea J. Robinson

Keyword(s):

Amino Acid ◽

Enantioselective Synthesis ◽

Amino Acid Derivatives

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ChemInform Abstract: Enantioselective Synthesis of β-Aryl-γ-amino Acid Derivatives via Cu-Catalyzed Asymmetric 1,4-Reductions of γ-Phthalimido-Substituted α,β-Unsaturated Carboxylic Acid Esters

ChemInform ◽

10.1002/chin.200850070 ◽

2008 ◽

Vol 39 (50) ◽

Author(s):

Jun Deng ◽

Xiang-Ping Hu ◽

Jia-Di Huang ◽

Sai-Bo Yu ◽

Dao-Yong Wang ◽

...

Keyword(s):

Amino Acid ◽

Carboxylic Acid ◽

Enantioselective Synthesis ◽

Amino Acid Derivatives ◽

Unsaturated Carboxylic Acid ◽

Acid Esters

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Enantioselective synthesis of optically active cis-β-thio-α-amino acid derivatives through an organocatalytic cascade thio-Michael/ring opening process

Chemical Communications ◽

10.1039/c2cc30799e ◽

2012 ◽

Vol 48 (39) ◽

pp. 4713 ◽

Cited By ~ 22

Author(s):

Zhi-Cong Geng ◽

Ning Li ◽

Jian Chen ◽

Xiao-Fei Huang ◽

Bin Wu ◽

...

Keyword(s):

Amino Acid ◽

Ring Opening ◽

Optically Active ◽

Enantioselective Synthesis ◽

Amino Acid Derivatives ◽

Opening Process

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Enantioselective synthesis of α-alkenyl α-amino acids via N–H insertion reactions

Chemical Science ◽

10.1039/c5sc03558a ◽

2016 ◽

Vol 7 (2) ◽

pp. 1104-1108 ◽

Cited By ~ 27

Author(s):

Jun-Xia Guo ◽

Ting Zhou ◽

Bin Xu ◽

Shou-Fei Zhu ◽

Qi-Lin Zhou

Keyword(s):

Amino Acids ◽

Amino Acid ◽

Enantioselective Synthesis ◽

Insertion Reaction ◽

Amino Acid Derivatives ◽

Insertion Reactions ◽

Phosphoric Acids

A new highly enantioselective route to α-alkenyl α-amino acid derivatives using a N–H insertion reaction of vinyldiazoacetates and tert-butyl carbamate cooperatively catalyzed by achiral dirhodium(ii) carboxylates and chiral spiro phosphoric acids was developed.

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Front Cover Picture: Enantioselective Synthesis of Oxindole‐Derived α‐Aryl‐β‐Amino Acid Derivatives and δ‐Lactams with Homophthalic Anhydrides (Adv. Synth. Catal. 24/2019)

Advanced Synthesis & Catalysis ◽

10.1002/adsc.201901499 ◽

2019 ◽

Vol 361 (24) ◽

pp. 5499-5499

Author(s):

Zhixin Chang ◽

Can Ye ◽

Junfeng Fu ◽

Paidamoyo Chigumbu ◽

Xiaofei Zeng ◽

...

Keyword(s):

Amino Acid ◽

Enantioselective Synthesis ◽

Amino Acid Derivatives ◽

Front Cover

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Phosphine-Catalyzed Doubly Stereoconvergent γ-Additions of Racemic Heterocycles to Racemic Allenoates: The Catalytic Enantioselective Synthesis of Protected α,α-Disubstituted α-Amino Acid Derivatives

Journal of the American Chemical Society ◽

10.1021/jacs.5b05528 ◽

2015 ◽

Vol 137 (29) ◽

pp. 9438-9442 ◽

Cited By ~ 57

Author(s):

Marcin Kalek ◽

Gregory C. Fu

Keyword(s):

Amino Acid ◽

Enantioselective Synthesis ◽

Amino Acid Derivatives

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ChemInform Abstract: Pd-Catalyzed Asymmetric Hydrogenation of α-Fluorinated Iminoesters in Fluorinated Alcohol: A New and Catalytic Enantioselective Synthesis of Fluoro α-Amino Acid Derivatives.

ChemInform ◽

10.1002/chin.200120068 ◽

2001 ◽

Vol 32 (20) ◽

pp. no-no

Author(s):

Hajime Abe ◽

Hideki Amii ◽

Kenji Uneyama

Keyword(s):

Amino Acid ◽

Asymmetric Hydrogenation ◽

Enantioselective Synthesis ◽

Amino Acid Derivatives ◽

Fluorinated Alcohol

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Correction to Organocatalytic Enantioselective Synthesis of α-Fluoro-β-amino Acid Derivatives

Organic Letters ◽

10.1021/acs.orglett.8b04089 ◽

2019 ◽

Vol 21 (3) ◽

pp. 849-849

Author(s):

Matthew R. Straub ◽

Vladimir B. Birman

Keyword(s):

Amino Acid ◽

Enantioselective Synthesis ◽

Amino Acid Derivatives

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Highly enantioselective synthesis of α-tertiary chiral amino acid derivatives through rhodium-catalyzed asymmetric arylation of cyclic N-sulfonyl α-ketimino esters

Organic & Biomolecular Chemistry ◽

10.1039/c8ob00840j ◽

2018 ◽

Vol 16 (25) ◽

pp. 4633-4640 ◽

Cited By ~ 9

Author(s):

Zheng Wang ◽

Ming-Hua Xu

Keyword(s):

Amino Acid ◽

Enantioselective Synthesis ◽

Amino Acid Derivatives ◽

Arylboronic Acids

A simple sulfur-olefin ligand promoted Rh-catalyzed highly enantioselective arylation of cyclic α-ketimino esters with arylboronic acids is described.

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