Circle-to-circle amplification on a digital microfluidic chip for amplified single molecule detection

Lab on a Chip ◽  
2014 ◽  
Vol 14 (16) ◽  
pp. 2983-2992 ◽  
Author(s):  
Malte Kühnemund ◽  
Daan Witters ◽  
Mats Nilsson ◽  
Jeroen Lammertyn
Keyword(s):  
Single Molecule ◽  
Microfluidic Chip ◽  
Dna Detection ◽  
Dna Amplification ◽  
Single Molecule Detection ◽  
Superparamagnetic Particle ◽  
Highly Efficient ◽  
Digital Microfluidic ◽  
Particle Extraction

We developed a novel highly efficient superparamagnetic particle extraction and shuttling protocol and integrated the isothermal circle-to-circle DNA amplification on a digital microfluidic chip for ultra-sensitive DNA detection.

Highly efficient single molecule detection in microstructures

2001 ◽  
Vol 86 (3) ◽  
pp. 225-236 ◽  
Author(s):  
Klaus Dörre ◽  
Jens Stephan ◽  
Markus Lapczyna ◽  
Michael Stuke ◽  
Holger Dunkel ◽  
...  
Keyword(s):  
Single Molecule ◽  
Single Molecule Detection ◽  
Highly Efficient

scholarly journals A microfluidic chip-compatible bioassay based on single-molecule detection with high sensitivity and multiplexing

Lab on a Chip ◽  
2010 ◽  
Vol 10 (7) ◽  
pp. 843 ◽  
Author(s):  
Randall E. Burton ◽  
Eric J. White ◽  
Ted R. Foss ◽  
Kevin M. Phillips ◽  
Robert H. Meltzer ◽  
...  
Keyword(s):  
Single Molecule ◽  
Microfluidic Chip ◽  
High Sensitivity ◽  
Single Molecule Detection

A highly efficient extraction protocol for magnetic particles on a digital microfluidic chip

2014 ◽  
Vol 196 ◽  
pp. 282-291 ◽  
Author(s):  
Nicolas Vergauwe ◽  
Steven Vermeir ◽  
Josias B. Wacker ◽  
Frederik Ceyssens ◽  
Matteo Cornaglia ◽  
...  
Keyword(s):  
Microfluidic Chip ◽  
Magnetic Particles ◽  
Extraction Protocol ◽  
Highly Efficient ◽  
Efficient Extraction ◽  
Digital Microfluidic

One-by-one single-molecule detection of mutated nucleobases by monitoring tunneling current using a DNA tip

2015 ◽  
Vol 51 (9) ◽  
pp. 1666-1669 ◽  
Author(s):  
Phuc Tan Bui ◽  
Tomoaki Nishino ◽  
Hiroshi Shiigi ◽  
Tsutomu Nagaoka
Keyword(s):  
Single Molecule ◽  
Dna Detection ◽  
Tunneling Current ◽  
Single Molecule Detection

Simple stationary monitoring of the tunneling current using a DNA tip leads to single-molecule DNA detection and discovery of base mismatches and methylation.

Drop driving on digital microfluidic chip

2020 ◽  
Vol 28 (11) ◽  
pp. 2488-2496
Author(s):  
Hong WANG ◽  
◽  
Jie ZHENG ◽  
Yan-peng YAN ◽  
Song WANG ◽  
...  
Keyword(s):  
Microfluidic Chip ◽  
Digital Microfluidic

scholarly journals A controlled T7 transcription-driven symmetric amplification cascade machinery for single-molecule detection of multiple repair glycosylases

2021 ◽  
Author(s):  
Li-juan Wang ◽  
Le Liang ◽  
Bing-jie Liu ◽  
BingHua Jiang ◽  
Chun-yang Zhang
Keyword(s):  
Single Molecule ◽  
Single Molecule Detection ◽  
Amplification Cascade

A controlled T7 transcription-driven symmetric amplification cascade machinery is developed for single-molecule detection of multiple repair glycosylases.

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