Magnetic and pH sensitive drug delivery system through NCA chemistry for tumor targeting

RSC Advances ◽  
2014 ◽  
Vol 4 (31) ◽  
pp. 15856-15862 ◽  
Author(s):  
Jingjing Wang ◽  
Chu Gong ◽  
Yinong Wang ◽  
Guolin Wu
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Tumor Targeting ◽  
Ph Sensitive ◽  
System P

Magnetic- and pH- dually sensitive drug delivery system.

Coumarin–benzothiazole–chlorambucil (Cou–Benz–Cbl) conjugate: an ESIPT based pH sensitive photoresponsive drug delivery system

2015 ◽  
Vol 3 (17) ◽  
pp. 3490-3497 ◽  
Author(s):  
Shrabani Barman ◽  
Sourav K. Mukhopadhyay ◽  
Moumita Gangopadhyay ◽  
Sandipan Biswas ◽  
Satyahari Dey ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Anticancer Drug ◽  
Delivery System ◽  
Ph Sensitive ◽  
Fluorescence Properties ◽  
System P

We have developed an ESIPT based drug delivery system, Cou–Benz–Cbl conjugate, with pH sensitive fluorescence properties and photocontrolled release of the anticancer drug chlorambucil.

pH-Responsive reversibly cross-linked micelles by phenol–yne click via curcumin as a drug delivery system in cancer chemotherapy

2019 ◽  
Vol 7 (24) ◽  
pp. 3884-3893 ◽  
Author(s):  
Yuancheng Liu ◽  
Fan Chen ◽  
Kui Zhang ◽  
Quan Wang ◽  
Yuanwei Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cancer Chemotherapy ◽  
Drug Loading ◽  
Ph Sensitive ◽  
Cross Linking ◽  
Ph Responsive ◽  
System P

pH-sensitive reversibly cross-linked micelles by phenol–yne click via curcumin (Cur) using mPEG-b-PHEMA-5HA are developed by combining drug loading and cross-linking as a drug delivery system.

A bio-inspired fluorescent nano-injectable hydrogel as a synergistic drug delivery system

2021 ◽  
Vol 45 (6) ◽  
pp. 3079-3087
Author(s):  
Yue Xu ◽  
Mingming Yang ◽  
Qiyue Ma ◽  
Xiang Di ◽  
Guolin Wu
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Fluorescence Properties ◽  
Injectable Hydrogel ◽  
Sequential Release ◽  
System P

A nano-injectable hydrogel with fluorescence properties and controlled sequential release of dual drugs.

scholarly journals In vitro evaluation of a novel pH sensitive drug delivery system based cockle shell-derived aragonite nanoparticles against osteosarcoma

2017 ◽  
Vol 12 (1) ◽  
pp. 166-187 ◽  
Author(s):  
Wenliang Fu ◽  
Mohd Hezmee Mohd Noor ◽  
Loqman Mohamad Yusof ◽  
Tengku Azmi Tengku Ibrahim ◽  
Yeap Swee Keong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
In Vitro Evaluation ◽  
Cockle Shell

New in-situ synthetized hydrogel composite based on alginate and brushite as a potential pH sensitive drug delivery system

2017 ◽  
Vol 177 ◽  
pp. 324-333 ◽  
Author(s):  
Seyed Mohammad Hossein Dabiri ◽  
Alberto Lagazzo ◽  
Fabrizio Barberis ◽  
Amirreza Shayganpour ◽  
Elisabetta Finocchio ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
Hydrogel Composite

scholarly journals Paclitaxel-loaded folate-coated long circulating and pH-sensitive liposomes as a potential drug delivery system: A biodistribution study

2018 ◽  
Vol 97 ◽  
pp. 489-495 ◽  
Author(s):  
Liziane O.F. Monteiro ◽  
Renata S. Fernandes ◽  
Caroline M.R. Oda ◽  
Sávia C. Lopes ◽  
Danyelle M. Townsend ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
Biodistribution Study ◽  
Potential Drug ◽  
System A

Macromolecular HPMA-Based Nanoparticles with Cholesterol for Solid-Tumor Targeting: Detailed Study of the Inner Structure of a Highly Efficient Drug Delivery System

2012 ◽  
Vol 13 (8) ◽  
pp. 2594-2604 ◽  
Author(s):  
Sergey K. Filippov ◽  
Petr Chytil ◽  
Petr V. Konarev ◽  
Margarita Dyakonova ◽  
ChristineM. Papadakis ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Solid Tumor ◽  
Tumor Targeting ◽  
Highly Efficient

Schiff base-containing dextran nanogel as pH-sensitive drug delivery system of doxorubicin: Synthesis and characterization

2018 ◽  
Vol 33 (2) ◽  
pp. 170-181 ◽  
Author(s):  
Hongying Su ◽  
Wen Zhang ◽  
Yayun Wu ◽  
Xiaodong Han ◽  
Gang Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Schiff Base ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
Cell Uptake ◽  
Stimuli Responsive ◽  
Drug Release Profile

Stimuli-responsive hydrogels have been widely researched as carrier systems, due to their excellent biocompatibility and responsiveness to external physiologic environment factors. In this study, dextran-based nanogel with covalently conjugated doxorubicin (DOX) was developed via Schiff base formation using the inverse microemulsion technique. Since the Schiff base linkages are acid-sensitive, drug release profile of the DOX-loaded nanogel would be pH-dependent. In vitro drug release studies confirmed that DOX was released much faster under acidic condition (pH 2.0, 5.0) than that at pH 7.4. Approximately 66, 28, and 9% of drug was released in 72 h at pH 2.0, 5.0, and 7.4, respectively. Cell uptake by the human breast cancer cell (MCF-7) demonstrated that the DOX-loaded dextran nanogel could be internalized through endocytosis and distributed in endocytic compartments inside tumor cells. These results indicated that the Schiff base-containing nanogel can serve as a pH-sensitive drug delivery system. And the presence of multiple aldehyde groups on the nanogel are available for further conjugations of targeting ligands or imaging probes.

scholarly journals Carboxymethyl cellulose-grafted graphene oxide for efficient antitumor drug delivery

2018 ◽  
Vol 7 (4) ◽  
pp. 291-301 ◽  
Author(s):  
Zepeng Jiao ◽  
Bin Zhang ◽  
Chunya Li ◽  
Weicong Kuang ◽  
Jingxian Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carboxymethyl Cellulose ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Tumor Growth Inhibition

Abstract A drug delivery system based on carboxymethyl cellulose-grafted graphene oxide loaded by methotrexate (MTX/CMC-GO) with pH-sensitive and controlled drug-release properties was developed in this work. CMC was grafted on graphene oxide by ethylenediamine through hydrothermal treatment. CMC serves as a pH-sensitive trigger, while CMC-GO serves as a drug-carrying vehicle due to the curved layer and large plain surface. Different amounts of drugs could be loaded into CMC-GO nanocarriers by control of the original amount of drug/carrier ratios. Additionally, low cytotoxicity against NIH-3T3 cells and low in vivo toxicity was observed. In vivo tumor growth inhibition assays showed that MTX/CMC-GO demonstrated superior antitumor activity than free MTX against HT-29 cells. Moreover, prolonged survival time of mice was observed after MTX/CMC-GO administration. The MTX/CMC-GO drug delivery system has a great potential in colon cancer therapy.

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