pH-Responsive reversibly cross-linked micelles by phenol–yne click via curcumin as a drug delivery system in cancer chemotherapy

2019 ◽  
Vol 7 (24) ◽  
pp. 3884-3893 ◽  
Author(s):  
Yuancheng Liu ◽  
Fan Chen ◽  
Kui Zhang ◽  
Quan Wang ◽  
Yuanwei Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cancer Chemotherapy ◽  
Drug Loading ◽  
Ph Sensitive ◽  
Cross Linking ◽  
Ph Responsive ◽  
System P

pH-sensitive reversibly cross-linked micelles by phenol–yne click via curcumin (Cur) using mPEG-b-PHEMA-5HA are developed by combining drug loading and cross-linking as a drug delivery system.

scholarly journals Supramolecular combination chemotherapy: a pH-responsive co-encapsulation drug delivery system

2020 ◽  
Vol 11 (24) ◽  
pp. 6275-6282 ◽  
Author(s):  
Junyi Chen ◽  
Yadan Zhang ◽  
Zhao Meng ◽  
Lei Guo ◽  
Xingyi Yuan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cancer Chemotherapy ◽  
Combination Chemotherapy ◽  
Chemotherapeutic Agents ◽  
Ph Responsive ◽  
System P

Most cancer chemotherapy regimens rely on the use of two or more chemotherapeutic agents. A supramolecular approach that may allow co-delivery of two drugs is described here.

Glutathione functionalized mesoporous organosilica conjugate for drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (61) ◽  
pp. 56287-56293 ◽  
Author(s):  
Lin-Lin Hu ◽  
Dan-Dan Zhang ◽  
Yang Zhang ◽  
Yang Shu ◽  
Xu-Wei Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Polyacrylic Acid ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Mesoporous Organosilica

We developed a novel pH-responsive drug delivery system based on permeation-enhancing glutathione (GSH) and pH sensitive polyacrylic acid (PAA) grafted mesoporous organosilica nanocarriers (MONs).

scholarly journals Interaction mechanism of doxorubicin and SWCNT: protonation and diameter effects on drug loading and releasing

RSC Advances ◽  
2016 ◽  
Vol 6 (1) ◽  
pp. 314-322 ◽  
Author(s):  
Yixuan Wang ◽  
Zhenfeng Xu
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Loading ◽  
Interaction Mechanism ◽  
System P

The encapsulation of DOX plays an important role in the design of a CNT-based drug delivery system.

A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways

Nanoscale ◽  
2017 ◽  
Vol 9 (27) ◽  
pp. 9428-9439 ◽  
Author(s):  
Kai Jiang ◽  
Ting Chi ◽  
Tao Li ◽  
Guirong Zheng ◽  
Lulu Fan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Ursolic Acid ◽  
Delivery System ◽  
Targeted Delivery ◽  
Cancer Growth ◽  
Ph Responsive ◽  
Nanodrug Delivery ◽  
System P ◽  
Multiple Signaling

Anti-tumor and anti-metastatic effects of ursolic acid based on one novel nanodrug delivery system.

Coumarin–benzothiazole–chlorambucil (Cou–Benz–Cbl) conjugate: an ESIPT based pH sensitive photoresponsive drug delivery system

2015 ◽  
Vol 3 (17) ◽  
pp. 3490-3497 ◽  
Author(s):  
Shrabani Barman ◽  
Sourav K. Mukhopadhyay ◽  
Moumita Gangopadhyay ◽  
Sandipan Biswas ◽  
Satyahari Dey ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Anticancer Drug ◽  
Delivery System ◽  
Ph Sensitive ◽  
Fluorescence Properties ◽  
System P

We have developed an ESIPT based drug delivery system, Cou–Benz–Cbl conjugate, with pH sensitive fluorescence properties and photocontrolled release of the anticancer drug chlorambucil.

Formation of pH-responsive drug-delivery systems by electrospinning of vesicle-templated nanocapsule solutions

RSC Advances ◽  
2016 ◽  
Vol 6 (48) ◽  
pp. 42589-42595 ◽  
Author(s):  
W. Li ◽  
X. N. Tan ◽  
T. Luo ◽  
X. Huang ◽  
Q. Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Sodium Alginate ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Electrospinning Process ◽  
Nanofibrous Membrane ◽  
Ph Responsive ◽  
System P

A novel nanofibrous membrane, which contains chitosan/sodium alginate nanocapsules constructed by vesicle systems, has been fabricated via an electrospinning process as a drug-delivery system.

A pH-responsive drug delivery system with an aggregation-induced emission feature for cell imaging and intracellular drug delivery

2015 ◽  
Vol 6 (26) ◽  
pp. 4715-4718 ◽  
Author(s):  
Haibo Wang ◽  
Gongyan Liu ◽  
Haiqi Gao ◽  
Yunbing Wang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cell Imaging ◽  
Emission Feature ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Therapeutic Treatment ◽  
Aggregation Induced Emission ◽  
Intracellular Drug Delivery

A pH-sensitive fluorescent vehicle based on aggregation-induced emission (AIE) has been developed as a drug delivery system for simultaneous cell imaging and therapeutic treatment.

scholarly journals A pH-responsive mesoporous silica nanoparticles-based drug delivery system with controlled release of andrographolide for OA treatment

2021 ◽  
Vol 8 (4) ◽  
Author(s):  
Mingwei He ◽  
Zainen Qin ◽  
Xiaonan Liang ◽  
Xixi He ◽  
Bikang Zhu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Cruciate Ligament ◽  
Drug Loading ◽  
Inflammatory Factors ◽  
Ph Responsive

Abstract Andrographolide (AG) has favorable anti-inflammatory and antioxidative capacity. However, it has low bioavailability due to high lipophilicity and can be easily cleared by the synovial fluid after intra-articular injection, leading to low therapeutic efficiency in osteoarthritis (OA). Herein, we designed a nano-sized pH-responsive drug delivery system (DDS) for OA treatment by using modified mesoporous silica nanoparticles (MSNs) with pH-responsive polyacrylic acid (PAA) for loading of AG to form AG@MSNs-PAA nanoplatform. The nanoparticles have uniform size (∼120 nm), high drug loading efficiency (22.38 ± 0.71%) and pH-responsive properties, beneficial to sustained release in OA environment. Compared with AG, AG@MSNs-PAA showed enhanced antiarthritic efficacy and chondro-protective capacity based on IL-1β-stimulated chondrocytes and anterior cruciate ligament transection-induced rat OA model, as demonstrated by lower expression of inflammatory factors and better prevention of proteoglycan loss. Therefore, the AG@MSNs-PAA nanoplatform may be developed as a promising OA-specific and on-demand DDS.

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