Validated assay for the evaluation of multiple glucuronidation activities in human liver microsomes via liquid chromatography-tandem mass spectrometry

Rong Shi; Yuanyuan Yang; Jie Zhong; Tianming Wang; Yueming Ma

doi:10.1039/c4ra10687c

Validated assay for the evaluation of multiple glucuronidation activities in human liver microsomes via liquid chromatography-tandem mass spectrometry

RSC Advances ◽

10.1039/c4ra10687c ◽

2014 ◽

Vol 4 (99) ◽

pp. 56132-56138 ◽

Cited By ~ 3

Author(s):

Rong Shi ◽

Yuanyuan Yang ◽

Jie Zhong ◽

Tianming Wang ◽

Yueming Ma

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Human Liver ◽

Liver Microsomes ◽

Tandem Mass ◽

Activity Determination ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

A faster and more accurate LC-MS/MS method was established for the activity determination of multiple UGT isoforms in HLMs.

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Determination of 4-Hydroxy-3-methoxymethamphetamine as a Metabolite of Methamphetamine in Rats and Human Liver Microsomes Using Gas Chromatography-Mass Spectrometry and Liquid Chromatography-Tandem Mass Spectrometry

Journal of Analytical Toxicology ◽

10.1093/jat/33.5.266 ◽

2009 ◽

Vol 33 (5) ◽

pp. 266-271 ◽

Cited By ~ 5

Author(s):

K. Kuwayama ◽

K. Tsujikawa ◽

H. Miyaguchi ◽

T. Kanamori ◽

Y. T. Iwata ◽

...

Keyword(s):

Mass Spectrometry ◽

Gas Chromatography ◽

Liquid Chromatography ◽

Human Liver ◽

Liver Microsomes ◽

Gas Chromatography Mass Spectrometry ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

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A liquid chromatography/tandem mass spectrometry method for detecting UGT-mediated bioactivation of drugs as theirN-acetylcysteine adducts in human liver microsomes

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.3912 ◽

2009 ◽

Vol 23 (5) ◽

pp. 564-570 ◽

Cited By ~ 14

Author(s):

Hiroshi Harada ◽

Takuro Endo ◽

Yasunori Momose ◽

Hiroshi Kusama

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Human Liver ◽

Liver Microsomes ◽

Tandem Mass ◽

Spectrometry Method ◽

Mass Spectrometry Method ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

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Characterization ofin vitrometabolites of TM-2, a potential antitumor drug, in rat, dog and human liver microsomes using liquid chromatography/tandem mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.7003 ◽

2014 ◽

Vol 28 (20) ◽

pp. 2162-2170 ◽

Cited By ~ 5

Author(s):

Lei Men ◽

Yunli Zhao ◽

Hongli Lin ◽

Mingjing Yang ◽

Hui Liu ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Human Liver ◽

Liver Microsomes ◽

Antitumor Drug ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass ◽

Potential Antitumor

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Metabolism of Prazosin in Rat, Dog, and Human Liver Microsomes and Cryopreserved Rat and Human Hepatocytes and Characterization of Metabolites by Liquid Chromatography/Tandem Mass Spectrometry

Drug Metabolism and Disposition ◽

10.1124/dmd.106.013219 ◽

2007 ◽

Vol 35 (6) ◽

pp. 908-916 ◽

Cited By ~ 28

Author(s):

John C. L. Erve ◽

Sarvesh C. Vashishtha ◽

William DeMaio ◽

Rasmy E. Talaat

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Human Liver ◽

Liver Microsomes ◽

Human Hepatocytes ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

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Simultaneous Screening of Activities of Five Cytochrome P450 and Four Uridine 5′-Diphospho-glucuronosyltransferase Enzymes in Human Liver Microsomes Using Cocktail Incubation and Liquid Chromatography–Tandem Mass Spectrometry

Drug Metabolism and Disposition ◽

10.1124/dmd.114.063016 ◽

2015 ◽

Vol 43 (7) ◽

pp. 1137-1146 ◽

Cited By ~ 15

Author(s):

Boram Lee ◽

Hyeon-Kyeong Ji ◽

Taeho Lee ◽

Kwang-Hyeon Liu

Keyword(s):

Mass Spectrometry ◽

Cytochrome P450 ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

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Identification of primary and sequential bioactivation pathways of carbamazepine in human liver microsomes using liquid chromatography/tandem mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.3220 ◽

2007 ◽

Vol 21 (20) ◽

pp. 3317-3322 ◽

Cited By ~ 16

Author(s):

Hai-Zhi Bu ◽

Ping Zhao ◽

Deepak K. Dalvie ◽

William F. Pool

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

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Stable Isotope Labeling Strategy for Curcumin Metabolite Study in Human Liver Microsomes by Liquid Chromatography-Tandem Mass Spectrometry

Journal of the American Society for Mass Spectrometry ◽

10.1007/s13361-014-1064-z ◽

2015 ◽

Vol 26 (4) ◽

pp. 686-694 ◽

Cited By ~ 9

Author(s):

Dan Gao ◽

Xiaowu Chen ◽

Xiaomei Yang ◽

Qin Wu ◽

Feng Jin ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Stable Isotope ◽

Tandem Mass Spectrometry ◽

Human Liver ◽

Isotope Labeling ◽

Liver Microsomes ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

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Simultaneous Determination of a Novel Diphenylpiperazine Calcium Channel Blocker and Its Four Metabolites in Rat Liver Microsomes by Liquid Chromatography Tandem Mass Spectrometry

Pharmacology ◽

10.1159/000337036 ◽

2012 ◽

Vol 89 (3-4) ◽

pp. 201-210 ◽

Cited By ~ 4

Author(s):

Wei Guo ◽

Dezhi Kong ◽

Yingfeng Du ◽

Xiaowei Shi ◽

Wei Wang ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Channel Blocker ◽

Liver Microsomes ◽

Tandem Mass ◽

Rat Liver Microsomes ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

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Comparative metabolism study of β-lapachone in mouse, rat, dog, monkey, and human liver microsomes using liquid chromatography–tandem mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2013.05.028 ◽

2013 ◽

Vol 83 ◽

pp. 286-292 ◽

Cited By ~ 7

Author(s):

Sangkyu Lee ◽

In Sook Kim ◽

Tae Hwan Kwak ◽

Hye Hyun Yoo

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Human Liver ◽

Liver Microsomes ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Comparative Metabolism ◽

Liquid Chromatography Tandem Mass ◽

Metabolism Study

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Identification of 4-hydroxynonenal protein targets in rat, mouse and human liver microsomes by two-dimensional liquid chromatography/tandem mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.7577 ◽

2016 ◽

Vol 30 (13) ◽

pp. 1488-1494 ◽

Cited By ~ 5

Author(s):

Makan Golizeh ◽

Timon Geib ◽

Lekha Sleno

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Human Liver ◽

Liver Microsomes ◽

Tandem Mass ◽

Two Dimensional ◽

Protein Targets ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

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