Spin crossover iron(ii) complexes as PARACEST MRI thermometers

2014 ◽  
Vol 5 (6) ◽  
pp. 2461-2465 ◽  
Author(s):  
Ie-Rang Jeon ◽  
Jesse G. Park ◽  
Chad R. Haney ◽  
T. David Harris
Keyword(s):  
Magnetic Resonance Imaging ◽  
Spin Crossover ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Potential Utility ◽  
Saturation Transfer ◽  
Resonance Imaging ◽  
Temperature Responsive ◽  
Mri Thermometry ◽  
Magnetic Resonance Imaging Mri

We demonstrate the potential utility of spin crossover iron(ii) complexes as temperature-responsive paramagnetic chemical exchange saturation transfer (PARACEST) contrast agents in magnetic resonance imaging (MRI) thermometry.

Chemical exchange saturation transfer (CEST): an efficient tool for detecting molecular information on proteins' behaviour

The Analyst ◽  
2014 ◽  
Vol 139 (11) ◽  
pp. 2687-2690 ◽  
Author(s):  
Dario Livio Longo ◽  
Enza Di Gregorio ◽  
Riccardo Abategiovanni ◽  
Alberto Ceccon ◽  
Michael Assfalg ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Lipid Membranes ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Resonance Imaging ◽  
Efficient Tool ◽  
Molecular Information ◽  
Magnetic Resonance Imaging Mri

In this communication, we report that protein remodeling processes, such as aggregation, unfolding and interaction with lipid membranes, may be investigated by magnetic resonance imaging (MRI) through the CEST mechanism.

Complexes of selected late period lanthanide(III) cations with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid amide (DOTAM)-alkyl ligands — A new platform for the development of paramagnetic chemical exchange saturation transfer (PARACEST) magnetic resonance imaging (MRI) contrast agents

2013 ◽  
Vol 91 (3) ◽  
pp. 211-219 ◽  
Author(s):  
Adam A.H. Elmehriki ◽  
Mark Milne ◽  
Mojmír Suchý ◽  
Robert Bartha ◽  
Robert H.E. Hudson
Keyword(s):  
Magnetic Resonance Imaging ◽  
Chemical Exchange ◽  
Acid Amide ◽  
Mri Contrast Agents ◽  
Chemical Exchange Saturation Transfer ◽  
Tetraacetic Acid ◽  
Saturation Transfer ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Magnetic Resonance Imaging Mri

A series of 18 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid amide (DOTAM)-alkyl derived complexes with selected late lanthanide(III) cations (Dy3+, Tb3+, and Tm3+) has been synthesized; their magnetic properties have been evaluated and compared to those derived from DOTAM. Peralkylation of cyclen with corresponding N-iodoacetyl amines was utilized as the key step in the synthesis. Chemical exchange saturation transfer (CEST) spectra of the complexes have been acquired at 37 °C, revealing that Tm3+-derived DOTAM-alkyl complexes possess the most favorable properties as potential paramagnetic chemical exchange saturation transfer (PARACEST) magnetic resonance imaging (MRI) contrast agents.

Glymphatic System Visualized by Chemical-Exchange-Saturation-Transfer Magnetic Resonance Imaging

2020 ◽  
Vol 11 (13) ◽  
pp. 1978-1984 ◽  
Author(s):  
Yuanfeng Chen ◽  
Zhuozhi Dai ◽  
Ruhang Fan ◽  
David John Mikulis ◽  
Jinming Qiu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Resonance Imaging ◽  
Glymphatic System
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