Water-soluble inclusion complex of fullerene with γ-cyclodextrin polymer for photodynamic therapy

2014 ◽  
Vol 2 (31) ◽  
pp. 5107-5115 ◽  
Author(s):  
Wang Zhang ◽  
Xiangdong Gong ◽  
Chang Liu ◽  
Yuanzhe Piao ◽  
Yun Sun ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Inclusion Complex ◽  
Water Soluble ◽  
Cyclodextrin Polymer ◽  
Uva Irradiation

A method was developed to obtain a highly water-soluble C60–γ-CDP inclusion complex, which could efficiently generate 1O2 species with UVA irradiation.

Investigation of water-soluble inclusion complex of hypericin with β-cyclodextrin polymer

2013 ◽  
Vol 95 (1) ◽  
pp. 366-370 ◽  
Author(s):  
Wang Zhang ◽  
Xiangdong Gong ◽  
Yin Cai ◽  
Chuanli Zhang ◽  
Xing Yu ◽  
...  
Keyword(s):  
Inclusion Complex ◽  
Water Soluble ◽  
Cyclodextrin Polymer

Solubility Enhancement of the Poorly Water-Soluble Antiulcer Drug Famotidine by Inclusion Complexation

2013 ◽  
Vol 6 (1) ◽  
pp. 1983-1989 ◽  
Author(s):  
Shabnam Ain ◽  
V Gupta ◽  
Babita K ◽  
Q Ain ◽  
J Dahiya
Keyword(s):  
Inclusion Complex ◽  
Dissolution Rate ◽  
Phosphate Buffer ◽  
Physical Mixture ◽  
Water Soluble ◽  
Molar Ratio ◽  
Phase Solubility ◽  
Distilled Water ◽  
Physicochemical Interaction ◽  
Mixture Phase

Aqueous solubility is a critical factor for optimum drug delivery. In the present study, we investigated the potential of drug-cyclodextrin complexation as an approach for improving the solubility and bioavailability of famotidine, an H2-receptor antagonist and acid reducing drug which has poor solubility and bioavailability. Solubility improvement of drug by β-cyclodextrin was done by simple complexation approach using physical, kneading and co-precipitation methods and compared with physical mixture. Phase solubility profile indicated that the solubility of famotidine was significantly increased in presence of β-cyclodextrin and shows a linear graph with β-cyclodextrin indicating formation of inclusion complexes in a 1:1 molar ratio. β-Cyclodextrin-famotidine mixture have maximum stability constant 1477.6 M-1. The inclusion complex ratio 1:1 of kneading mixture was selected based on drug release profile and compared with physical mixture. Further characterization was done by  using Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) to identify the physicochemical interaction between drug and carrier and its effect on dissolution. Dissolution rate studies for selected inclusion complex was performed in 0.1 N HCl (pH 1.2), phosphate buffer (pH 7.5) and distilled water (pH 6.8) and compared these to pure drug profile which was found to be 2.34 fold increase in distilled water, 1.83 fold in HCl and 2.01 fold in phosphate buffer (pH 7.5). These results suggest that the kneaded complex of famotidine with β-cyclodextrin as hydrophilic complexation agent can substantially enhance the solubility and dissolution rate. Such complex has promising potential to improve the bioavailability of famotidine.  

Synthesis of a novel linear water-soluble ?-cyclodextrin polymer

2005 ◽  
Vol 54 (3) ◽  
pp. 594-599 ◽  
Author(s):  
Estelle Renard ◽  
Gis�le Volet ◽  
Catherine Amiel
Keyword(s):  
Water Soluble ◽  
Cyclodextrin Polymer

BEHAVIOURAL STUDY OF CYCLODEXTRIN INCLUSION COMPLEX ON ENHANCEMENT OF SOLUBILITY OF ACECLOFENAC

INDIAN DRUGS ◽  
2015 ◽  
Vol 52 (11) ◽  
pp. 19-23
Author(s):  
J Shaikh ◽  
◽  
S. V. Deshmane ◽  
R. N Purohit ◽  
K. R. Biyani
Keyword(s):  
Inclusion Complex ◽  
Solid Dispersion ◽  
Water Soluble ◽  
In Vitro Dissolution ◽  
Phase Solubility ◽  
Solubility Study ◽  
Cyclodextrin Inclusion ◽  
Poorly Water Soluble ◽  
Cyclodextrin Inclusion Complex

The main objective of the present study was to enhance the solubility and dissolution rate of poorly water soluble aceclofenac using its solid dispersion with β-cyclodextrin. FTIR and DSC study was carried out to find out any incompatibility. The phase solubility of drug was carried out in 1, 2, 5, and 10% of β-cyclodextrin in distilled water. Kneading method and solvent evaporation method was use to prepared solid dispersion of aceclofenac and β-cyclodextrin. Different evaluation tests like solubility study in different solvents, PXRD and in vitro dissolution study of aceclofenac- β-cyclodextrin inclusion complex were carried out. The overall finding indicated that β-cyclodextrin is a desirable water soluble carrier, that helps in increasing solubility of drug. Due to its structural feature, β-cyclodextrin forms a good inclusion complex that decreases contact angle of drug with water molecules by increasing wetting properties. Hence, it can be concluded that, β-cyclodextrin is better water soluble carrier molecule in terms of its compatibility and increasing solubility behavior of poorly water soluble drug aceclofenac.

Simple nanophotosensitizer fabrication using water-soluble chitosan for photodynamic therapy in gastrointestinal cancer cells

2017 ◽  
Vol 532 (1) ◽  
pp. 194-203 ◽  
Author(s):  
Young-IL Jeong ◽  
Byungyoul Cha ◽  
Hye Lim Lee ◽  
Yeon Hui Song ◽  
Yun Hye Jung ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Gastrointestinal Cancer ◽  
Water Soluble

Water-soluble dendritic polyaspartic porphyrins: potential photosensitizers for photodynamic therapy

2012 ◽  
Vol 36 (1) ◽  
pp. 28-31 ◽  
Author(s):  
Baoxiang Gao ◽  
Yueling Liu ◽  
Huijuan Yin ◽  
Yingxin Li ◽  
Qianqian Bai ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Water Soluble
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