scholarly journals Water-soluble dopamine-based polymers for photoacoustic imaging

2015 ◽  
Vol 51 (28) ◽  
pp. 6084-6087 ◽  
Author(s):  
Tatjana Repenko ◽  
Stanley Fokong ◽  
Laura De Laporte ◽  
Dennis Go ◽  
Fabian Kiessling ◽  
...  
Keyword(s):  
Linear Form ◽  
Photoacoustic Imaging ◽  
Water Soluble ◽  
Synthetic Method ◽  
High Contrast

Here we present a facile synthetic method yielding a linear form of polydopamineviaKumada-coupling, which can be converted into water-soluble melanin, generating high contrast in photoacoustic imaging.

scholarly journals High contrast three-dimensional photoacoustic imaging through scattering media by localized optical fluence enhancement

2013 ◽  
Vol 21 (22) ◽  
pp. 26671 ◽  
Author(s):  
Antonio M. Caravaca-Aguirre ◽  
Donald B. Conkey ◽  
Jacob D. Dove ◽  
Hengyi Ju ◽  
Todd W. Murray ◽  
...  
Keyword(s):  
Photoacoustic Imaging ◽  
Three Dimensional ◽  
High Contrast ◽  
Scattering Media

scholarly journals High-contrast photoacoustic imaging through scattering media using correlation detection of adaptive time window

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Liqi Yu ◽  
Jialin Sun ◽  
Xinjing Lv ◽  
Qi Feng ◽  
Huimei He ◽  
...  
Keyword(s):  
Light Scattering ◽  
Time Window ◽  
Photoacoustic Imaging ◽  
Signal To Noise Ratio ◽  
Photoacoustic Signal ◽  
High Contrast ◽  
Scattering Media ◽  
Window Method ◽  
Adaptive Time ◽  
Imaging Depth

AbstractPhotoacoustic imaging has the advantages of high contrast and deep imaging depth. However, with the increasing of imaging depth, the signal-to-noise ratio (SNR) of the detected signal decreases, due to the light scattering that seriously affects the recovery image quality. In this paper, we experimentally demonstrated that higher contrast photoacoustic imaging was achieved using photoacoustic wavefront shaping technology in the presence of light scattering and low SNR signals. The imaging contrast is improved from 1.51 to 5.30. More importantly, we propose a dynamic time window method for the photoacoustic signal extraction algorithm, named correlation detection of adaptive time window, which further improves the contrast of photoacoustic imaging to 9.57. Our method effectively improves the contrast of photoacoustic imaging through scattering media.

scholarly journals Water Soluble Melanin Derivatives for Dynamic Contrast Enhanced Photoacoustic Imaging of Tumor Vasculature and Response to Antiangiogenic Therapy

2016 ◽  
Vol 6 (1) ◽  
pp. 1600550 ◽  
Author(s):  
Dario L. Longo ◽  
Rachele Stefania ◽  
Chiara Callari ◽  
Francesco De Rose ◽  
Riccardo Rolle ◽  
...  
Keyword(s):  
Photoacoustic Imaging ◽  
Antiangiogenic Therapy ◽  
Tumor Vasculature ◽  
Water Soluble ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced

Photoacoustic Imaging: Hybrid Technology for Small Animals Holding Potentials Translatable for Clinical applications

2014 ◽  
Vol 4 (1) ◽  
pp. 427-432
Author(s):  
Daniela Berritto ◽  
Francesca Iacobellis ◽  
Maria Paola Belfiore ◽  
Michele La Porta ◽  
Roberto Grassi
Keyword(s):  
Imaging System ◽  
Photoacoustic Imaging ◽  
Hybrid Approach ◽  
Laser Wavelength ◽  
The Body ◽  
High Contrast ◽  
Photoacoustic Effect ◽  
Ultrasound Signal ◽  
Light Diffusion ◽  
Transducer Frequency

Photoacoustic imaging is an emerging modality that exploits the photoacoustic effect to combine the high contrast of optical imaging with the spatial resolution and penetration depth of ultrasound. A key feature of PA imaging methods is that they exploit optical contrast but employ US detection principles. The PA effect offers a way to take advantage of the ability of light to penetrate into the body and let us defeat light diffusion by using US waves to “see” the penetrating light. The main advantage of this hybrid approach is that the optical properties of biological tissue, including high contrast and spectral specificity, are encoded in an ultrasound signal. Resolutions of better than 1 mm can be obtained at depths measured in centimeters (up to 7) and not in millimeters, depending on the laser wavelength and transducer frequency used, opening up entirely new regimens of “optical imaging.” From a clinical standpoint, PA imaging is complementary in nature and synergetic with US and a combined US and PA imaging system can be easily implemented due to the presence of a shared detector and associated electronics. Furthermore, such a system will be readily accepted by clinicians familiar with US imaging.

Zwitterionic diketopyrrolopyrrole for fluorescence/photoacoustic imaging guided photodynamic/photothermal therapy

2018 ◽  
Vol 9 (20) ◽  
pp. 2805-2812 ◽  
Author(s):  
Weixing Deng ◽  
Qi Wu ◽  
Pengfei Sun ◽  
Pengcheng Yuan ◽  
Xiaomei Lu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Renal Excretion ◽  
Photoacoustic Imaging ◽  
Water Soluble

Water-soluble zwitterionic diketopyrrolopyrrole (DPP-SPMA) for fluorescence/photoacoustic imaging guided photodynamic/photothermal therapy with favorable renal excretion and ultralow cytotoxicity.

A Water‐Soluble, NIR‐Absorbing Quaterrylenediimide Chromophore for Photoacoustic Imaging and Efficient Photothermal Cancer Therapy

2019 ◽  
Vol 131 (6) ◽  
pp. 1652-1656 ◽  
Author(s):  
Chang Liu ◽  
Shaobo Zhang ◽  
Jianhao Li ◽  
Jie Wei ◽  
Klaus Müllen ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Photoacoustic Imaging ◽  
Water Soluble

scholarly journals Engineering an NIR rhodol derivative with spirocyclic ring-opening activation for high-contrast photoacoustic imaging

2019 ◽  
Vol 10 (40) ◽  
pp. 9257-9264 ◽  
Author(s):  
Feng Liu ◽  
Xiao Shi ◽  
Xianjun Liu ◽  
Fenglin Wang ◽  
Hai-Bo Yi ◽  
...  
Keyword(s):  
Ring Opening ◽  
Photoacoustic Imaging ◽  
High Contrast

A novel NIR rhodol derivative is engineered for the development of high-contrast activatable photoacoustic imaging based on generally applicable ring-opening responsiveness.

scholarly journals RGD-Functionalized Melanin Nanoparticles for Intraoperative Photoacoustic Imaging-Guided Breast Cancer Surgery

2021 ◽  
Author(s):  
Jing-Jing Liu ◽  
Zun Wang ◽  
Li-Ming Nie ◽  
Yuan-Yuan Zhu ◽  
Ge Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Surgical Resection ◽  
Photoacoustic Imaging ◽  
Water Soluble ◽  
Breast Cancer Surgery ◽  
Tumour Resection ◽  
Histopathological Analysis ◽  
Tumour Targeting ◽  
Tumour Bearing

Abstract Purpose: Obtaining tumour-free margins is critical for avoiding re-excision and 35 reducing local recurrence following breast-conserving surgery (BCS); however, it 36 remains challenging. Imaging-guided surgery provides precise detection of residual 37 lesions and assists surgical resection. Herein, we describe water-soluble melanin 38 nanoparticles (MNPs) conjugated with cyclic Arg-Gly-Asp (cRGD) peptides for breast 39 cancer photoacoustic imaging (PAI) and surgery navigation. 40Methods: cRGD-MNPs was synthesized and characterized for morphology, 41 photoacoustic characteristics and stability. Tumour targeting and toxicity were 42 determined by cells and tumour-bearing mice. PAI was used to locate the tumour and 43 guide surgical resection in MDA-MB-231 tumour-bearing mice. 44Results: The cRGD-MNPs exhibited excellent tumour-targeting in vitro and in vivo, 45 with low toxicity. Intravenous administration of cRGD-MNPs to MDA-MB-231 46 tumour-bearing mice showed an approximately 2.1-fold enhancement in photoacoustic 47 (PA) intensity at 2 h, and the ratio of the PA intensity at the tumour site compared to 48 that in the surrounding normal tissue was 3.2 ± 0.1, which was much higher than that 49 using MNPs alone (1.7 ± 0.3). Similarly, the PA signal in the mammary glands 50 containing spontaneous breast cancer was enhanced (2.5 ± 0.3-fold) in MMTV-PyVT 51 transgenic murine model. Preoperative screening by PAI could assess tumour volume 52 and offer a three-dimensional (3D) reconstruction image for accurate surgical planning. 53 Surgical resection following real-time PAI on the tumour bed showed high consistency 54 with histopathological analysis. 55Conclusion: These results highlight that cRGD-MNPs combined with PAI provide 56 a powerful tool for breast cancer imaging and precise tumour resection. cRGD-MNPs 57 with good PA properties have great potential for clinical translation.

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