scholarly journals Engineered biosynthesis of natural products in heterologous hosts

2015 ◽  
Vol 44 (15) ◽  
pp. 5265-5290 ◽  
Author(s):  
Yunzi Luo ◽  
Bing-Zhi Li ◽  
Duo Liu ◽  
Lu Zhang ◽  
Yan Chen ◽  
...  
Keyword(s):  
Natural Products ◽  
Synthetic Biology

Biosynthesis of natural products in heterologous hosts is improved significantly with new tools and strategies in synthetic biology.

Biosynthesis and synthetic biology of psychoactive natural products

2021 ◽  
Author(s):  
Cooper S. Jamieson ◽  
Joshua Misa ◽  
Yi Tang ◽  
John M. Billingsley
Keyword(s):  
Natural Products ◽  
Synthetic Biology ◽  
Biological Activities ◽  
Engineering Applications ◽  
Pathway Discovery

The biosynthetic logic employed by Nature in the construction of psychoactive natural products is reviewed, in addition to biological activities, methodologies enabling pathway discovery, and engineering applications.

scholarly journals Synthetic biology of plant natural products: from pathway elucidation to engineered biosynthesis in plant cells

2021 ◽  
pp. 100229
Author(s):  
Xiaoxi Zhu ◽  
Xiaonan Liu ◽  
Tian Liu ◽  
Yina Wang ◽  
Nida Ahmed ◽  
...  
Keyword(s):  
Natural Products ◽  
Synthetic Biology ◽  
Plant Cells ◽  
Plant Natural Products

scholarly journals Natural Products and Synthetic Biology: Where We Are and Where We Need To Go

mSystems ◽  
2019 ◽  
Vol 4 (3) ◽  
Author(s):  
Sylvia Kunakom ◽  
Alessandra S. Eustáquio
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Synthetic Biology ◽  
Genome Sequencing ◽  
Scientific Community ◽  
Microbial Metabolites ◽  
Bacterial Genomes ◽  
Cholesterol Lowering

ABSTRACT The biosynthetic talent of microorganisms has been harnessed for drug discovery for almost a century. Microbial metabolites not only account for the majority of antibiotics available today, but have also led to anticancer, immunosuppressant, and cholesterol-lowering drugs. Yet, inherent challenges of natural products—including inadequate supply and difficulties with structure diversification—contributed to their deprioritization as a source of pharmaceuticals. In recent years, advances in genome sequencing and synthetic biology spurred a renewed interest in natural products. Bacterial genomes encode an abundance of natural products awaiting discovery. Synthetic biology can facilitate not only discovery and improvements in supply, but also structure diversification. This perspective highlights prior accomplishments in the field of synthetic biology and natural products by the scientific community at large, including research from our laboratory. We also provide our opinion as to where we need to go to continue advancing the field.

scholarly journals Recent advances in natural products exploitation in Streptomyces via synthetic biology

2019 ◽  
Vol 19 (6) ◽  
pp. 452-462 ◽  
Author(s):  
Qiyuan Zhao ◽  
Liping Wang ◽  
Yunzi Luo
Keyword(s):  
Natural Products ◽  
Synthetic Biology ◽  
Recent Advances

scholarly journals mSphere of Influence: Synthetic Biology of Natural Product Biosynthesis

mSphere ◽  
2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Mark C. Walker
Keyword(s):  
Natural Products ◽  
Synthetic Biology ◽  
Natural Product ◽  
Gene Cluster ◽  
Biosynthetic Gene Cluster ◽  
Biosynthetic Gene ◽  
Natural Product Biosynthesis ◽  
Antibiotic Compounds ◽  
Approaches To Study

ABSTRACT Mark Walker studies the biosynthesis and engineering of bacterial natural products with the long-term goal of identifying new antibiotic compounds. In this mSphere of Influence, he reflects on how “Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A” by K. Yamanaka, K. A. Reynolds, R. D. Kersten, K. S. Ryan, et al. (Proc Natl Acad Sci USA 111:1957–1962, 2014, https://doi.org/10.1073/pnas.1319584111) impacted his thinking on using synthetic biology approaches to study natural product biosynthesis.

scholarly journals Synthetic Biology of Natural Products

2016 ◽  
Vol 8 (10) ◽  
pp. a023994 ◽  
Author(s):  
Rainer Breitling ◽  
Eriko Takano
Keyword(s):  
Natural Products ◽  
Synthetic Biology

scholarly journals Modern mass spectrometry for synthetic biology and structure-based discovery of natural products

2016 ◽  
Vol 33 (8) ◽  
pp. 942-950 ◽  
Author(s):  
Matthew T. Henke ◽  
Neil L. Kelleher
Keyword(s):  
Mass Spectrometry ◽  
Natural Products ◽  
Synthetic Biology ◽  
Modern Mass ◽  
Natural Products Discovery

This highlight serves as a primer for those curious about the abilities of mass spectrometry for natural products discovery and engineering.

Natural products from synthetic biology

2011 ◽  
Vol 15 (4) ◽  
pp. 505-515 ◽  
Author(s):  
Wayne Mitchell
Keyword(s):  
Natural Products ◽  
Synthetic Biology

scholarly journals Natural product biosyntheses in cyanobacteria: A treasure trove of unique enzymes

2011 ◽  
Vol 7 ◽  
pp. 1622-1635 ◽  
Author(s):  
Jan-Christoph Kehr ◽  
Douglas Gatte Picchi ◽  
Elke Dittmann
Keyword(s):  
Natural Products ◽  
Synthetic Biology ◽  
Natural Product ◽  
Bioactive Compounds ◽  
Polyketide Synthase ◽  
Biosynthetic Pathways ◽  
Peptide Synthetase ◽  
Biochemical Studies ◽  
Terrestrial Habitats ◽  
The Individual

Cyanobacteria are prolific producers of natural products. Investigations into the biochemistry responsible for the formation of these compounds have revealed fascinating mechanisms that are not, or only rarely, found in other microorganisms. In this article, we survey the biosynthetic pathways of cyanobacteria isolated from freshwater, marine and terrestrial habitats. We especially emphasize modular nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) pathways and highlight the unique enzyme mechanisms that were elucidated or can be anticipated for the individual products. We further include ribosomal natural products and UV-absorbing pigments from cyanobacteria. Mechanistic insights obtained from the biochemical studies of cyanobacterial pathways can inspire the development of concepts for the design of bioactive compounds by synthetic-biology approaches in the future.

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