1,3,4-Oxadiazole derivatives as potential antitumor agents: discovery, optimization and biological activity valuation

MedChemComm ◽  
2016 ◽  
Vol 7 (2) ◽  
pp. 263-271 ◽  
Author(s):  
Yin Luo ◽  
Zhi-Jun Liu ◽  
Guo Chen ◽  
Jing Shi ◽  
Jing-Ran Li ◽  
...  
Keyword(s):  
Biological Activity ◽  
Anticancer Activity ◽  
Active Compound ◽  
Inhibitory Activity ◽  
Antitumor Agents ◽  
Docking Simulation ◽  
Binding Model ◽  
Oxadiazole Derivatives ◽  
Potential Antitumor

New 1,3,4-oxadiazole derivatives have been synthesized and evaluated for their FAK inhibitory activity and anticancer activity. The most active compound 5h was studied by docking simulation to explore the binding model.

Synthesis and biological activity of selenopsammaplin A and its analogues as antitumor agents with DOT1L inhibitory activity

2021 ◽  
Vol 35 ◽  
pp. 116072 ◽  
Author(s):  
Hae Ju Han ◽  
Woong Sub Byun ◽  
Gyu Ho Lee ◽  
Won Kyung Kim ◽  
Kyungkuk Jang ◽  
...  
Keyword(s):  
Biological Activity ◽  
Inhibitory Activity ◽  
Antitumor Agents

Synthesis and Biological Activity of Anthrapyrazoles Derivatives as Potential Antitumor Agents

2014 ◽  
Vol 10 (8) ◽  
pp. 772-777
Author(s):  
Jianhong Wang ◽  
Huijun Zhao ◽  
Zhaoyang Luo ◽  
Zhaoyi Wang ◽  
Yahong Zhang ◽  
...  
Keyword(s):  
Biological Activity ◽  
Antitumor Agents ◽  
Potential Antitumor

Potential antitumor agents. Part 43. Synthesis and biological activity of dibasic 9-aminoacridine-4-carboxamides, a new class of antitumor agent

1984 ◽  
Vol 27 (11) ◽  
pp. 1481-1485 ◽  
Author(s):  
Graham J. Atwell ◽  
Bruce F. Cain ◽  
Bruce C. Baguley ◽  
Graeme J. Finlay ◽  
William A. Denny
Keyword(s):  
Biological Activity ◽  
Antitumor Agents ◽  
Antitumor Agent ◽  
New Class ◽  
Potential Antitumor
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