Rational design of DNA-actuated enzyme nanoreactors guided by single molecule analysis

Nanoscale ◽  
2016 ◽  
Vol 8 (5) ◽  
pp. 3125-3137 ◽  
Author(s):  
Soma Dhakal ◽  
Matthew R. Adendorff ◽  
Minghui Liu ◽  
Hao Yan ◽  
Mark Bathe ◽  
...  

Using experimental and computational approaches to define sequence-level design principles that enable rationally improved closure and tweezer-actuated enzyme function of a DNA tweezer.

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