Design, synthesis and biological evaluation of 5′-C-piperidinyl-5′-O-aminoribosyluridines as potential antibacterial agents

2015 ◽  
Vol 13 (28) ◽  
pp. 7720-7735 ◽  
Author(s):  
Takeshi Nakaya ◽  
Akira Matsuda ◽  
Satoshi Ichikawa
Keyword(s):  
Antibacterial Activity ◽  
Antibacterial Agents ◽  
Biological Evaluation ◽  
Human Cells ◽  
Ritter Reaction ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Caprazamycin analogues, which were designed and synthesized via an aza-Prins–Ritter reaction, exhibit a good MraY and antibacterial activity without cytotoxicity against human cells.

scholarly journals Design, synthesis and evaluation of anti-inflammatory, analgesic and antibacterial activity of 2, 4, 6-trisubstituted quinazoline derivatives

2018 ◽  
Vol 29 (2) ◽  
pp. 97-102
Author(s):  
Nivrati Jain ◽  
Harshita Jain ◽  
Ashish Jain ◽  
Veerasamy Ravichandran ◽  
Prateek Jain
Keyword(s):  
Antibacterial Activity ◽  
Antibacterial Agents ◽  
Biological Evaluation ◽  
Spectroscopy Analysis ◽  
Design Synthesis ◽  
E Coli ◽  
Quinazoline Derivatives ◽  
Anti Inflammatory ◽  
Synthesis And Biological Evaluation ◽  
Mass Spectroscopy Analysis

Abstract We described here the synthesis and biological evaluation of a series of 2, 4, 6-trisubstituted quinazoline derivatives as potential anti-inflammatory, analgesic and antibacterial agents. The synthesized compounds were characterized by FTIR, 1H NMR and mass spectroscopy analysis. We found that the compounds 6b, 6e, 6g, 6h and 6j showed better anti-inflammatory activity than indomethacin. Compounds 6b, 6e, 6h, 6j and 6l were found to exhibit appreciable analgesic activity, and 6b, 6g and 6k showed good antibacterial activity against Gram (+) bacteria: B. subtilis, S. aureus, S. epidermis, and Gram (-) bacteria: E. coli, P. aeruginosa and K. pneumoniae. Compound 6b showed overall better anti-inflammatory, analgesic and antibacterial activity among the synthesized compounds. The results of the present study could be helpful for the designing of effective anti-inflammatory, analgesic and antibacterial agents.

Design, Synthesis, and Biological Evaluation of Hexacyclic Tetracyclines as Potent, Broad Spectrum Antibacterial Agents

2015 ◽  
Vol 58 (11) ◽  
pp. 4703-4712 ◽  
Author(s):  
Cuixiang Sun ◽  
Diana K. Hunt ◽  
Chi-Li Chen ◽  
Yonghong Deng ◽  
Minsheng He ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Antibacterial Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

ChemInform Abstract: Design, Synthesis, and Biological Evaluation of Indolylidinepyrazolones as Potential Antibacterial Agents.

ChemInform ◽  
2015 ◽  
Vol 46 (8) ◽  
pp. no-no
Author(s):  
A. Indrasena ◽  
Sd. Riyaz ◽  
Prema L. Mallipeddi ◽  
P. Padmaja ◽  
B. Sridhar ◽  
...  
Keyword(s):  
Antibacterial Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals LpxC Inhibitors: Design, Synthesis, and Biological Evaluation of Oxazolidinones as Gram-negative Antibacterial Agents

2016 ◽  
Vol 7 (6) ◽  
pp. 623-628 ◽  
Author(s):  
Haruaki Kurasaki ◽  
Kosuke Tsuda ◽  
Mariko Shinoyama ◽  
Noriko Takaya ◽  
Yuko Yamaguchi ◽  
...  
Keyword(s):  
Antibacterial Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Gram Negative ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of novel flavone Mannich base derivatives as potential antibacterial agents

2018 ◽  
Vol 23 (2) ◽  
pp. 299-306 ◽  
Author(s):  
Xian-Hai Lv ◽  
Hao Liu ◽  
Zi-Li Ren ◽  
Wei Wang ◽  
Feng Tang ◽  
...  
Keyword(s):  
Antibacterial Agents ◽  
Mannich Base ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation
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