NIS-catalyzed oxidative cyclization of alcohols with amidines: a simple and efficient transition-metal free method for the synthesis of 1,3,5-triazines

2015 ◽  
Vol 13 (45) ◽  
pp. 10973-10976 ◽  
Author(s):  
Abhishek R. Tiwari ◽  
Akash T. ◽  
Bhalchandra M. Bhanage
Keyword(s):  
Transition Metal ◽  
Efficient Method ◽  
Oxidative Cyclization ◽  
Metal Free ◽  
Reaction Works

A simple and efficient method for the synthesis of 1,3,5-triazines by NIS-catalyzed oxidative cyclization of alcohols with amidines has been developed. The reaction works smoothly under transition-metal and phosphine-free conditions.

Transition-metal-free and facile synthesis of 3-alkynylpyrrole-2, 4-dicarboxylates from methylene isocyanides and propiolaldehyde

2021 ◽  
Author(s):  
Xiaoli Huo ◽  
Xiaojuan Chen ◽  
Liya Yu ◽  
Chong Zhang ◽  
Linghui Zeng ◽  
...  
Keyword(s):  
Transition Metal ◽  
Efficient Method ◽  
Transformation Process ◽  
Facile Synthesis ◽  
Direct Transformation ◽  
Metal Free

A transition-metal-free, facile and efficient method for the synthesis of 3-alkynylpyrrole-2, 4-dicarboxylates from methylene isocyanides and propiolaldehyde with moderate to good yields has been developed. The direct transformation process and...

Diiiodine/Potassium Persulfate Mediated Synthesis of 1,2,3-Thiadiazoles from N-Tosylhydrazones and a Thiocyanate Salt as a Sulfur Source under Transition-Metal-Free Conditions

Synlett ◽  
2021 ◽  
Author(s):  
Yadong Sun ◽  
Ablimit Abdukader ◽  
Yuhan Lu ◽  
Chenjiang Liu
Keyword(s):  
Transition Metal ◽  
Efficient Method ◽  
Room Temperature ◽  
Functional Group ◽  
Ammonium Thiocyanate ◽  
Potassium Persulfate ◽  
Sulfur Source ◽  
Coupling Reactions ◽  
Wide Scope ◽  
Metal Free

AbstractA highly efficient method for the synthesis of 1,2,3-thiadiazoles has been developed by utilizing readily available tosylhydrazones and ammonium thiocyanate with ecofriendly EtOH as the solvent at room temperature. The reaction shows a wide scope of substrates and good functional-group tolerance. This protocol can be scaled up to a gram level and can be applied to coupling reactions with 4-(4-bromophenyl)-1,2,3-thiadiazole as the substrate.

Hydride-Induced Anionic Cyclization: An Efficient Method for the Synthesis of 6-H-Phenanthridines via a Transition-Metal-Free Process

2015 ◽  
Vol 17 (6) ◽  
pp. 1613-1616 ◽  
Author(s):  
Wei-Lin Chen ◽  
Chun-Yuan Chen ◽  
Yan-Fu Chen ◽  
Jen-Chieh Hsieh
Keyword(s):  
Transition Metal ◽  
Efficient Method ◽  
Metal Free ◽  
Free Process

Transition-metal-free access to 2-aminopyridine derivatives from 2-fluoropyridine and acetamidine hydrochloride

2018 ◽  
Vol 16 (41) ◽  
pp. 7564-7567 ◽  
Author(s):  
Yibiao Li ◽  
Shuo Huang ◽  
Chunshu Liao ◽  
Yan Shao ◽  
Lu Chen
Keyword(s):  
Transition Metal ◽  
Nucleophilic Substitution ◽  
Efficient Method ◽  
Free Access ◽  
Metal Free ◽  
Catalyst Free ◽  
Hydrolysis Of

Under catalyst-free conditions, an efficient method for the synthesis of 2-aminopyridine derivatives through the nucleophilic substitution and hydrolysis of 2-fluoropyridine and acetamidine hydrochloride has been developed.

Green and practical transition metal-free one-pot conversion of substituted benzoic acids to anilines using tosyl azide

2016 ◽  
Vol 3 (12) ◽  
pp. 1680-1685 ◽  
Author(s):  
Andivelu Ilangovan ◽  
Palaniappan Sakthivel ◽  
Pandaram Sakthivel
Keyword(s):  
Transition Metal ◽  
Efficient Method ◽  
Crucial Role ◽  
Benzoic Acids ◽  
Electronic Effects ◽  
One Pot ◽  
Metal Free ◽  
Substituted Benzoic Acids

A simple and efficient method for conversion of 2-iodo/2-nitro benzoic acids and dihydropyranone-fused benzoic acids into corresponding anilines, using tosyl azide, under transition metal-free conditions was developed. Steric and electronic effects play crucial role.

Convenient Synthesis of Benzofuro[3,2-b]quinolines from 1-Azadienes and Arynes

Synthesis ◽  
2021 ◽  
Author(s):  
Qi Wang ◽  
Yan Wang ◽  
Shi-Kai Tian
Keyword(s):  
Transition Metal ◽  
Efficient Method ◽  
Fluoride Ion ◽  
Metal Free ◽  
Convenient Synthesis

An efficient method has been developed for the synthesis of benzofuro[3,2-b]quinolines through tandem [4+2] cycloaddition/aromatization under transition-metal-free conditions. A range of aurone-derived N-tosyl-1-azadienes smoothly reacted with arynes, generated in situ via fluoride ion-induced 1,2-elimination of 2-(trimethylsilyl)aryl triflates, delivering structurally diverse benzofuro[3,2-b]quinolines in moderate to good yields.

Transition-metal-free oxidative cyclization reaction of enynals to access pyrane-2-one derivatives

2021 ◽  
Author(s):  
Farzaneh Ansari ◽  
Hormoz Khosravi ◽  
Alireza Abbasi Kejani ◽  
Mahsa Armaghan ◽  
Walter Frank ◽  
...  
Keyword(s):  
Transition Metal ◽  
Oxidative Cyclization ◽  
Cyclization Reaction ◽  
Metal Free

K2S2O8 is introduced as an oxygen source and C–H functionalization agent in a novel selective metal-free oxidative cyclization of enynals to synthesize α-pyrone derivatives with a relatively broad substrate scope via the formation of two C–O bonds.

Transition-metal-free cross-coupling of thioethers with aryl(cyano)iodonium triflates: a facile and efficient method for the one-pot synthesis of thiocyanates

2015 ◽  
Vol 51 (33) ◽  
pp. 7180-7183 ◽  
Author(s):  
Dan Zhu ◽  
Denghu Chang ◽  
Lei Shi
Keyword(s):  
Transition Metal ◽  
Efficient Method ◽  
Bond Cleavage ◽  
Cross Coupling ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis ◽  
One Step ◽  
The One

A novel transition-metal-free method for the one-step synthesis of thiocyanates via the C–S bond cleavage of readily available thioethers was developed.

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