Simultaneous quantification of multiple volatile active components in rat plasma using a headspace-solid phase dynamic extraction method coupled to gas chromatography-tandem mass spectroscopy: application in a pharmacokinetic study of Longhu Rendan pills

RSC Advances ◽  
2015 ◽  
Vol 5 (38) ◽  
pp. 29631-29638 ◽  
Author(s):  
Tian-Ming Wang ◽  
Li-Qing Ding ◽  
Hua-Jia Jin ◽  
Rong Shi ◽  
Jia-Sheng Wu ◽  
...  
Keyword(s):  
Extraction Method ◽  
Solid Phase ◽  
Rat Plasma ◽  
Tandem Mass ◽  
Active Components ◽  
Phase Dynamic ◽  
Simultaneous Quantification ◽  
Tandem Mass Spectroscopy ◽  
Dynamic Extraction ◽  
Solid Phase Dynamic Extraction

A HS-SPDE-GC-MS/MS method for investigating pharmacokinetics of l-menthol, borneol, isoborneol, and camphor in rat plasma after oral administration of LRPs.

scholarly journals Influence of Different Extraction Parameters on a Solid-Phase Dynamic Extraction for the Gas Chromatographic Determination of d-Limonene Degradation Products by Using a Fractional Factorial Design

2007 ◽  
Vol 90 (6) ◽  
pp. 1623-1627 ◽  
Author(s):  
Marion Kamphoff ◽  
Tobias Thiele ◽  
Benno Kunz
Keyword(s):  
Incubation Temperature ◽  
Solid Phase ◽  
Degradation Products ◽  
Fractional Factorial ◽  
Desorption Process ◽  
Phase Dynamic ◽  
Dynamic Extraction ◽  
Extraction Parameters ◽  
Solid Phase Dynamic Extraction

Abstract Through the application of a solid-phase dynamic extraction (SPDE) method for the determination of volatile substances, different parameters may influence the extraction and desorption process and are, therefore, vital for the determination of the extracted substances via gas chromatography (GC). In this study, the influence of extraction und desorption parameters of an SPDE-GC method for the determination of the d-limonene degradation products, namely, -terpineol, (-)-carveol, and (S)-carvone, in an aqueous model system was evaluated using a factorial fractional design. The aim was to reduce the number of factors that should be considered for the optimization of an SPDE procedure for different applications. It could be shown that the extraction efficiency of -terpineol, (-)-carveol, and (S)-carvone is significantly influenced by the extraction parameters incubation temperature, number of extraction strokes, and amount of added NaCl. All 3 parameters have a positive effect on the extraction and determination of the examined d-limonene degradation products. Due to the identification of significant factors on the basis of an experimental design, the results of this study can be very useful for further development of SPDE methods for different applications.

Automated headspace solid-phase dynamic extraction for the determination of cannabinoids in hair samples

2003 ◽  
Vol 133 (1-2) ◽  
pp. 32-38 ◽  
Author(s):  
Frank Musshoff ◽  
Dirk W Lachenmeier ◽  
Lars Kroener ◽  
Burkhard Madea
Keyword(s):  
Solid Phase ◽  
Phase Dynamic ◽  
Hair Samples ◽  
Dynamic Extraction ◽  
Solid Phase Dynamic Extraction
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