Synthesis and bioactivity of gelatin/multiwalled carbon nanotubes/hydroxyapatite nanofibrous scaffolds towards bone tissue engineering

RSC Advances ◽  
2015 ◽  
Vol 5 (66) ◽  
pp. 53550-53558 ◽  
Author(s):  
Hualin Wang ◽  
Chengjiang Chu ◽  
Ruizhi Cai ◽  
Suwei Jiang ◽  
Linfeng Zhai ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Multiwalled Carbon Nanotubes ◽  
Multiwalled Carbon ◽  
Nanofibrous Scaffolds

The in vitro bioactivity of scaffolds, and the adhesion, mineralization, viability and proliferation of hFOBs on gelatin/MWNTs/HA nanofibrous scaffolds.

scholarly journals Development of Chitosan/Poly(L-Lactide)/Multiwalled Carbon Nanotubes Scaffolds for Bone Tissue Engineering

2016 ◽  
Vol 05 (01) ◽  
pp. 14-23 ◽  
Author(s):  
A. De la Paz Orozco ◽  
F. Jiménez Vega ◽  
S. A. Martel-Estrada ◽  
A. Hernández Aguilar ◽  
M. E. Mendoza-Duarte ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Multiwalled Carbon Nanotubes ◽  
Multiwalled Carbon

scholarly journals Poly(3-Hydroxybutyrate)-Multiwalled Carbon Nanotubes Electrospun Scaffolds Modified with Curcumin

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2588
Author(s):  
Nader Tanideh ◽  
Negar Azarpira ◽  
Najmeh Sarafraz ◽  
Shahrokh Zare ◽  
Aida Rowshanghiyas ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Tissue Engineering ◽  
Multiwalled Carbon Nanotubes ◽  
Inflammatory Reaction ◽  
3D Structure ◽  
Hydrolytic Degradation ◽  
Multiwalled Carbon ◽  
Electrospun Scaffolds

Appropriate selection of suitable materials and methods is essential for scaffolds fabrication in tissue engineering. The major challenge is to mimic the structure and functions of the extracellular matrix (ECM) of the native tissues. In this study, an optimized 3D structure containing poly(3-hydroxybutyrate) (P3HB), multiwalled carbon nanotubes (MCNTs) and curcumin (CUR) was created by electrospinning a novel biomimetic scaffold. CUR, a natural anti-inflammatory compound, has been selected as a bioactive component to increase the biocompatibility and reduce the potential inflammatory reaction of electrospun scaffolds. The presence of CUR in electrospun scaffolds was confirmed by 1H NMR and Fourier-transform infrared spectroscopy (FTIR). Scanning electron microscopy (SEM) revealed highly interconnected porosity of the obtained 3D structures. Addition of up to 20 wt% CUR has enhanced mechanical properties of the scaffolds. CUR has also promoted in vitro bioactivity and hydrolytic degradation of the electrospun nanofibers. The developed P3HB-MCNT composite scaffolds containing 20 wt% of CUR revealed excellent in vitro cytocompatibility using mesenchymal stem cells and in vivo biocompatibility in rat animal model study. Importantly, the reduced inflammatory reaction in the rat model after 8 weeks of implantation has also been observed for scaffolds modified with CUR. Overall, newly developed P3HB-MCNTs-CUR electrospun scaffolds have demonstrated their high potential for tissue engineering applications.

Diels–Alder functionalized carbon nanotubes for bone tissue engineering: in vitro/in vivo biocompatibility and biodegradability

Nanoscale ◽  
2015 ◽  
Vol 7 (20) ◽  
pp. 9238-9251 ◽  
Author(s):  
D. Mata ◽  
M. Amaral ◽  
A. J. S. Fernandes ◽  
B. Colaço ◽  
A. Gama ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Biological Response ◽  
Diels Alder ◽  
Functionalized Carbon Nanotubes

Diels–Alder functionalization accounts for the improved CNT biological response in terms of biocompatibility and biodegradability profiles.

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