Cytotoxic heteroleptic heptacoordinate salan zirconium(iv)-bis-chelates – synthesis, aqueous stability and X-ray structure analysis
Keyword(s):
X Ray
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A series of novel Zr(iv)salan complexes is reported. The initial metalation product[(L1)2Zr]is highly water sensitive whereas ligand exchanged[L1Zr(dipic)]hydrolyses rather slowly with a bis-hydroxo Zr(iv) species identified by MS as an intermediate.[L1Zr(dipic)]is cytotoxic in the range of cisplatin against two human carcinoma cell lines.