Three-component carboarylation of unactivated imines with arynes and carbon nucleophiles

2017 ◽  
Vol 53 (10) ◽  
pp. 1708-1711 ◽  
Author(s):  
Jing-Kun Xu ◽  
Sheng-Jun Li ◽  
Hai-Yang Wang ◽  
Wen-Cong Xu ◽  
Shi-Kai Tian
Keyword(s):  
Transition Metal ◽  
Tertiary Amines ◽  
Title Reaction ◽  
Metal Free ◽  
Carbon Nucleophiles ◽  
Reaction Proceeds

With 2-(trimethylsilyl)aryl triflates as aryne precursors, the title reaction proceeds smoothly to afford functionalized tertiary amines under transition metal-free conditions.

A metal-free radical cascade reaction of phosphine oxides with 2-aryloxy phenylacetylenes to assemble diphosphonyl xanthene derivatives

2021 ◽  
Author(s):  
Tao Fan ◽  
Yan Liu ◽  
Caina Jiang ◽  
Yanli Xu ◽  
Yan-Yan Chen
Keyword(s):  
Free Radical ◽  
Transition Metal ◽  
Cascade Reaction ◽  
Phosphine Oxides ◽  
Metal Free ◽  
Mild Conditions ◽  
Xanthene Derivatives ◽  
Reaction Proceeds ◽  
Radical Cascade

A radical cascade reaction of 2-aryloxy phenylacetylene with phosphine oxides promoted by K2S2O8 was developed, provided diphosphonyl xanthenes as products. This reaction proceeds under transition metal-free and mild conditions with...

ChemInform Abstract: Employing Arynes in Transition-Metal-Free Monoarylation of Aromatic Tertiary Amines.

ChemInform ◽  
2014 ◽  
Vol 45 (13) ◽  
pp. no-no
Author(s):  
Sachin Suresh Bhojgude ◽  
Trinadh Kaicharla ◽  
Akkattu T. Biju
Keyword(s):  
Transition Metal ◽  
Tertiary Amines ◽  
Metal Free

scholarly journals Et3N/DMSO-supported one-pot synthesis of highly fluorescent β-carboline-linked benzothiophenones via sulfur insertion and estimation of the photophysical properties

2020 ◽  
Vol 16 ◽  
pp. 1740-1753 ◽  
Author(s):  
Dharmender Singh ◽  
Vipin Kumar ◽  
Virender Singh
Keyword(s):  
Transition Metal ◽  
Elemental Sulfur ◽  
Photophysical Properties ◽  
Quantum Yields ◽  
One Pot ◽  
Light Emitting ◽  
Metal Free ◽  
One Pot Synthesis ◽  
Synthetic Strategy ◽  
Reaction Proceeds

A robust transition-metal-free strategy is presented to access novel β-carboline-tethered benzothiophenone derivatives from 1(3)-formyl-β-carbolines using elemental sulfur activated by Et3N/DMSO. This expeditious catalyst-free reaction proceeds through the formation of β-carboline-based 2-nitrochalcones followed by an incorporation of sulfur to generate multifunctional β-carboline-linked benzothiophenones in good to excellent yields. The synthetic strategy could also be extended towards the synthesis of β-carboline-linked benzothiophenes. Moreover, the afforded products emerged as promising fluorophores and displayed excellent light-emitting properties with quantum yields (ΦF) up to 47%.

Transition metal-free oxidative ortho-acylation of phenols with N-heteroarylmethanes via double C–H activation

2016 ◽  
Vol 6 (15) ◽  
pp. 5792-5796 ◽  
Author(s):  
Min Liu ◽  
Tieqiao Chen ◽  
Yongbo Zhou ◽  
Shuang-Feng Yin
Keyword(s):  
Transition Metal ◽  
Metal Free ◽  
Reaction Proceeds ◽  
Plausible Mechanism ◽  
Double Activation

The direct oxidative acylation of phenols with N-heteroarylmethanes via sp3C–H and sp2C–H double activation was achieved under metal-free conditions. The reaction proceeds in a facile I2/DMSO/O2 system regio-selectively to produce valuable (2-hydroxyphenyl)arylmethanones. A plausible mechanism was proposed.

The peroxodisulfate-assisted three-component benzylation of coumarins with styrenes and KSCN: A transition-metal-free approach for the synthesis of 3-(1-aryl-2-thiocyanatoethyl)-2H-chromen-2-one in ethyl lactate

2021 ◽  
Author(s):  
Palani Natarajan ◽  
Priya ◽  
Deachen Chuskit
Keyword(s):  
Transition Metal ◽  
Ethyl Lactate ◽  
Metal Free ◽  
Reaction Proceeds ◽  
First Time

The peroxodisulfate-assisted three-component benzylation of coumarins with styrenes and KSCN to 3-(1-aryl-2-thiocyanatoethyl)-2H-chromen-2-one is reported for the first time. This reaction proceeds via the consecutive addition of SCN radical to styrenes...

Employing Arynes in Transition-Metal-Free Monoarylation of Aromatic Tertiary Amines

2013 ◽  
Vol 15 (21) ◽  
pp. 5452-5455 ◽  
Author(s):  
Sachin Suresh Bhojgude ◽  
Trinadh Kaicharla ◽  
Akkattu T. Biju
Keyword(s):  
Transition Metal ◽  
Tertiary Amines ◽  
Metal Free

Base mediated synthesis of functionalized 2‐(alkynyl)arylnitriles and their molecular docking study with aromatase receptor

2021 ◽  
Author(s):  
Ramendra Pratap ◽  
Chandan Shah ◽  
Pratik Yadav ◽  
Ismail Althagafi ◽  
Vishal Nemaysh ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Transition Metal ◽  
Docking Study ◽  
Molecular Docking Study ◽  
Metal Free ◽  
Reaction Proceeds

A simple, efficient, and transition metal-free approach to synthesize functionalized 2‐(alkynyl)benzonitriles has been developed using suitably functionalized 2H-pyran-2-ones and 4-phenyl/trimethylsilanyl-but-3-yn-2-ones as precursors. The reaction proceeds in presence of a base...

α-C-H functionalizations of tertiary amines catalyzed/promoted by molecular iodine/derivatives

2021 ◽  
Author(s):  
Mohit L. Deb ◽  
B Shriya Saikia ◽  
Paran J. Borpatra ◽  
Pranjal K. Baruah
Keyword(s):  
Transition Metal ◽  
Molecular Iodine ◽  
Review Article ◽  
Tertiary Amines ◽  
Metal Free ◽  
Organic Syntheses

This review article focuses on the functionalization of α-C-H bond of tertiary amines via C-H activation catalyzed by iodine or its derivatives. Recently, transition metal-free C-H functionalizations in organic syntheses...

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