The small molecule JIB-04 disrupts O2binding in the Fe-dependent histone demethylase KDM4A/JMJD2A
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X Ray
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The pyridine hydrazone JIB-04, a specific inhibitor of Fe- and α-ketoglutarate-dependent, O2-activating histone lysine demethylases, is found to block the binding of O2in KDM4A through an O2-consumption assay, X-ray crystal structure data, and molecular modeling.
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2018 ◽
Vol 74
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pp. a4-a4
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1976 ◽
Vol 98
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pp. 6049-6051
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2006 ◽
Vol 62
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pp. s119-s119
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2002 ◽
Vol 58
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pp. 380-388
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2008 ◽
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1975 ◽
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1986 ◽
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