scholarly journals Protein-engineering of an amine transaminase for the stereoselective synthesis of a pharmaceutically relevant bicyclic amine

2016 ◽  
Vol 14 (43) ◽  
pp. 10249-10254 ◽  
Author(s):  
Martin S. Weiß ◽  
Ioannis V. Pavlidis ◽  
Paul Spurr ◽  
Steven P. Hanlon ◽  
Beat Wirz ◽  
...  
Keyword(s):  
Transition Metal ◽  
Protein Engineering ◽  
Asymmetric Synthesis ◽  
Stereoselective Synthesis ◽  
Environmentally Benign ◽  
Attractive Alternative ◽  
P Application ◽  
Transition Metal Catalyzed ◽  
Prochiral Ketones ◽  
Metal Catalyzed

Application of amine transaminases (ATAs) for stereoselective amination of prochiral ketones represents an environmentally benign and economically attractive alternative to transition metal catalyzed asymmetric synthesis.

Asymmetric synthesis to chiral organosilicon compounds via transition metal-catalyzed stereoselective C-H activation and silylation

2021 ◽  
Author(s):  
Ming Zhang ◽  
Shan Gao ◽  
Juan Tang ◽  
Ling Chen ◽  
Aihua Liu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Asymmetric Synthesis ◽  
Organosilicon Compounds ◽  
Feature Article ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

This feature article introduces the progress of transition metal-catalyzed stereoselective sp2 and sp3 C-H activation and silylation to synthesize chiral organosilicon compounds, the asymmetric C-H silylation includes intramolecular cyclizing silylation...

Synergistic Catalysis for Stereodivergent Synthesis of trans- and cis-Skipped Dienes

Synlett ◽  
2020 ◽  
Vol 31 (18) ◽  
pp. 1741-1746
Author(s):  
Shenqqing Zhu ◽  
Lingling Chu ◽  
Fang Wang
Keyword(s):  
Transition Metal ◽  
Organic Synthesis ◽  
Stereoselective Synthesis ◽  
Triplet Energy ◽  
Synergistic Catalysis ◽  
The Cross ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed ◽  
Vinyl Triflates

Catalytic, stereoselective synthesis of skipped dienes is an important topic in organic synthesis. Summarized here are the transition-metal-catalyzed stereoselective approaches and a new, photoinduced stereodivergent strategy reported by our group recently. Our strategy utilizes a synergistic photoredox/nickel protocol to enable the cross-electrophile coupling of allylic carbonates and vinyl triflates to construct 1,4-dienes, the stereoselectivity of which was tuned by the triplet energy (E T) photocatalysts employed, offering a convenient and stereodivergent solution to (E)- and (Z)-1,4-dienes from one set of substrates.

Copper-catalyzed N-(hetero)arylation of amino acids in water

RSC Advances ◽  
2016 ◽  
Vol 6 (99) ◽  
pp. 96762-96767 ◽  
Author(s):  
Krishna K. Sharma ◽  
Meenakshi Mandloi ◽  
Neha Rai ◽  
Rahul Jain
Keyword(s):  
Amino Acids ◽  
Transition Metal ◽  
Cost Effective ◽  
Environmentally Benign ◽  
Cost Effective Method ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

A transition metal-catalyzed, environmentally benign, rapid and cost-effective method for the N-(hetero)arylation of zwitterionic amino acids in water is reported.

Transition-metal-catalyzed silylmetalation of acetylenes and its application to the stereoselective synthesis of steroidal side chains

1983 ◽  
Vol 105 (13) ◽  
pp. 4491-4492 ◽  
Author(s):  
Hiroshi Hayami ◽  
Mitsuyoshi Sato ◽  
Shigekazu Kanemoto ◽  
Yoshitomi Morizawa ◽  
Koichiro Oshima ◽  
...  
Keyword(s):  
Transition Metal ◽  
Stereoselective Synthesis ◽  
Side Chains ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

Asymmetric Synthesis of the Tricyclic Core of NGF-Inducing Cyathane Diterpenes via a Transition-Metal-Catalyzed [5 + 2] Cycloaddition

2001 ◽  
Vol 3 (13) ◽  
pp. 2105-2108 ◽  
Author(s):  
Paul A. Wender ◽  
F. Christopher Bi ◽  
Michael A. Brodney ◽  
Francis Gosselin
Keyword(s):  
Transition Metal ◽  
Asymmetric Synthesis ◽  
Tricyclic Core ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed
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