scholarly journals Two decades of new drug discovery and development for Alzheimer's disease

RSC Advances ◽  
2017 ◽  
Vol 7 (10) ◽  
pp. 6046-6058 ◽  
Author(s):  
Zhidong Liu ◽  
Aihua Zhang ◽  
Hui Sun ◽  
Ying Han ◽  
Ling Kong ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Discovery ◽  
Cognitive Function ◽  
Neurodegenerative Disease ◽  
Drug Discovery And Development ◽  
New Drug ◽  
Behavioral Abnormalities

Alzheimer's disease is a progressive and irreversible neurodegenerative disease, associated with a decreased cognitive function and severe behavioral abnormalities.

Challenges in Alzheimer's Disease Drug Discovery and Development: The Role of Modeling, Simulation, and Open Data

2020 ◽  
Vol 107 (4) ◽  
pp. 796-805 ◽  
Author(s):  
Daniela J. Conrado ◽  
Sridhar Duvvuri ◽  
Hugo Geerts ◽  
Jackson Burton ◽  
Carla Biesdorf ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Discovery ◽  
Open Data ◽  
Drug Discovery And Development ◽  
Modeling Simulation

Natural product for the treatment of Alzheimer’s disease

2017 ◽  
Vol 28 (5) ◽  
Author(s):  
Thanh Tung Bui ◽  
Thanh Hai Nguyen
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Natural Products ◽  
Cognitive Function ◽  
Medicinal Plants ◽  
Neurodegenerative Disease ◽  
Natural Product ◽  
Natural Compound ◽  
Anti Inflammatory

AbstractAlzheimer’s disease (AD) is related to increasing age. It is mainly characterized by progressive neurodegenerative disease, which damages memory and cognitive function. Natural products offer many options to reduce the progress and symptoms of many kinds of diseases, including AD. Meanwhile, natural compound structures, including lignans, flavonoids, tannins, polyphenols, triterpenes, sterols, and alkaloids, have anti-inflammatory, antioxidant, anti-amyloidogenic, and anticholinesterase activities. In this review, we summarize the pathogenesis and targets for treatment of AD. We also present several medicinal plants and isolated compounds that are used for preventing and reducing symptoms of AD.

The effects of caloric restriction and its mimetics in Alzheimer's disease through autophagy pathways

2020 ◽  
Vol 11 (2) ◽  
pp. 1211-1224 ◽  
Author(s):  
Yi Yang ◽  
Lihui Zhang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Function ◽  
Neurodegenerative Disease ◽  
Caloric Restriction ◽  
Rodent Models ◽  
Older Individuals ◽  
Amyloid Burden ◽  
Tau Pathology

AD is a neurodegenerative disease that commonly occurs among older individuals. Caloric restriction and its mimetics have been shown to alleviate amyloid burden, tau pathology, and improve cognitive function of rodent models of AD by activating autophagy.

What is the gold standard model for Alzheimer’s Disease drug discovery and development?

2021 ◽  
Author(s):  
Ramón Cacabelos ◽  
Iván Carrera ◽  
Olaia Martínez-Iglesias ◽  
Natalia Cacabelos ◽  
Vinogran Naidoo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Discovery ◽  
Standard Model ◽  
Gold Standard ◽  
Drug Discovery And Development
Sign in / Sign up

Export Citation Format

Share Document