Natural product for the treatment of Alzheimer’s disease

2017 ◽  
Vol 28 (5) ◽  
Author(s):  
Thanh Tung Bui ◽  
Thanh Hai Nguyen
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Natural Products ◽  
Cognitive Function ◽  
Medicinal Plants ◽  
Neurodegenerative Disease ◽  
Natural Product ◽  
Natural Compound ◽  
Anti Inflammatory

AbstractAlzheimer’s disease (AD) is related to increasing age. It is mainly characterized by progressive neurodegenerative disease, which damages memory and cognitive function. Natural products offer many options to reduce the progress and symptoms of many kinds of diseases, including AD. Meanwhile, natural compound structures, including lignans, flavonoids, tannins, polyphenols, triterpenes, sterols, and alkaloids, have anti-inflammatory, antioxidant, anti-amyloidogenic, and anticholinesterase activities. In this review, we summarize the pathogenesis and targets for treatment of AD. We also present several medicinal plants and isolated compounds that are used for preventing and reducing symptoms of AD.

Natural Anti-inflammatory compounds as Drug candidates in Alzheimer’s disease

2020 ◽  
Vol 27 ◽  
Author(s):  
Reyaz Hassan Mir ◽  
Abdul Jalil Shah ◽  
Roohi Mohi-ud-din ◽  
Faheem Hyder Potoo ◽  
Mohd. Akbar Dar ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Natural Products ◽  
Protective Action ◽  
New Drugs ◽  
Huperzine A ◽  
Brain Disorder ◽  
Anti Inflammatory

: Alzheimer's disease (AD) is a chronic neurodegenerative brain disorder characterized by memory impairment, dementia, oxidative stress in elderly people. Currently, only a few drugs are available in the market with various adverse effects. So to develop new drugs with protective action against the disease, research is turning to the identification of plant products as a remedy. Natural compounds with anti-inflammatory activity could be good candidates for developing effective therapeutic strategies. Phytochemicals including Curcumin, Resveratrol, Quercetin, Huperzine-A, Rosmarinic acid, genistein, obovatol, and Oxyresvertarol were reported molecules for the treatment of AD. Several alkaloids such as galantamine, oridonin, glaucocalyxin B, tetrandrine, berberine, anatabine have been shown anti-inflammatory effects in AD models in vitro as well as in-vivo. In conclusion, natural products from plants represent interesting candidates for the treatment of AD. This review highlights the potential of specific compounds from natural products along with their synthetic derivatives to counteract AD in the CNS.

Natural product-based nanomedicine: Recent advances and issues for the treatment of Alzheimer's disease

2021 ◽  
Vol 20 ◽  
Author(s):  
Choy Ker Woon ◽  
Wong Kah Hui ◽  
Razif Abas ◽  
Muhammad Huzaimi Haron ◽  
Srijit Das ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Natural Products ◽  
Medicinal Plants ◽  
Drug Transport ◽  
The Elderly ◽  
Current Evidence ◽  
Alternative Approach ◽  
Progressive Neurodegeneration ◽  
The Brain

: Alzheimer's disease (AD) affects the elderly and is characterized by progressive neurodegeneration caused by different pathologies. The most significant challenges in treating AD include the inability of medications to reach the brain because of its poor solubility, low bioavailability, and the presence of the blood-brain barrier (BBB). Additionally, current evidence suggests the disruption of BBB plays an important role in the pathogenesis of AD. One of the critical challenges in treating AD is the ineffective treatments and its severe adverse effects. Nanotechnology offers an alternative approach to facilitate the treatment of AD by overcoming the challenges in drug transport across the BBB. Various nanoparticles (NP) loaded with natural products were reported to aid in drug delivery for the treatment of AD. The nano- sized entities of NP are great platforms for incorporating active materials from natural products into formulations that can be delivered effectively to the intended action site without compromising the material’s bioactivity. The review highlights the applications of medicinal plants, their derived components, and various nanomedicine-based approaches for the treatment of AD. The combination of medicinal plants and nanotechnology may lead to new theragnostic solutions for the treatment of AD in the future.

Medicinal Plants and Their Bioactive Compounds for the Management and Treatment of Gout

2021 ◽  
pp. 267-287
Author(s):  
Bui Thanh Tung
Keyword(s):  
Natural Products ◽  
Uric Acid ◽  
Medicinal Plants ◽  
Bioactive Compounds ◽  
Inflammatory Arthritis ◽  
Natural Compound ◽  
Complex Form ◽  
Compound Structure ◽  
Anti Inflammatory

Gout is a complex form of arthritis which is characterized by sudden, severe attacks of pain, swelling, redness, and tenderness in the joints. Gout is a type of inflammatory arthritis that is triggered by the crystallization of uric acid within the joints and is often associated with hyperuricemia. Natural products offer many options to reduce the progress and symptoms of diseases, including gout. Natural compound structure including lignans, flavonoids, tannins, polyphenols, triterpenes, sterols, and alkaloids have anti-inflammatory, antioxidant, and XO activities. In this chapter, the authors present medicinal plants and isolated compounds which are used to prevent and reduce the pathogenesis of gout.

scholarly journals Alzheimer‘s disease: exploring nature’s ‘medicinal chest’ for new therapeutic agents

2020 ◽  
Vol 11 (1) ◽  
pp. 201-208
Author(s):  
Anthony Tsarbopoulos
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Natural Products ◽  
Medicinal Plants ◽  
Therapeutic Agents ◽  
Lead Compounds ◽  
Age Related ◽  
Aging Properties ◽  
Disease Modifying ◽  
Disease Modifying Agents

AbstractNatural products have served humanity as a valuable source for the discovery and development of therapeutic agents. In addition, these phytochemicals can function as lead compounds for the development of synthetic analogs aimed at treating human diseases. In our aging society, Alzheimer’s disease (AD) is the most common cause of dementia, which is characterized by a significant and progressive loss of memory and other cognitive functions. As society demographics change, the predominance of AD and other age-related dementias is increasing, with concurrent financial and societal costs.AD represents one of the most remarkable scientific challenges for drug discovery as the search for effective disease-modifying agents has been unsuccessful. Medicinal plants have been used for their “anti-aging” properties, and cognitive enhancing properties. In the past decades, natural products have been studied for their anti-AD properties, and their potential for developing therapeutic agents against several molecular targets has been evaluated. This insight evaluates the prospects of medicinal plants for providing disease-modifying, as well as disease-preventing, agents for AD.

The effects of caloric restriction and its mimetics in Alzheimer's disease through autophagy pathways

2020 ◽  
Vol 11 (2) ◽  
pp. 1211-1224 ◽  
Author(s):  
Yi Yang ◽  
Lihui Zhang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Function ◽  
Neurodegenerative Disease ◽  
Caloric Restriction ◽  
Rodent Models ◽  
Older Individuals ◽  
Amyloid Burden ◽  
Tau Pathology

AD is a neurodegenerative disease that commonly occurs among older individuals. Caloric restriction and its mimetics have been shown to alleviate amyloid burden, tau pathology, and improve cognitive function of rodent models of AD by activating autophagy.

scholarly journals Alzheimer’s disease: natural products as inhibitors of neuroinflammation

2020 ◽  
Vol 28 (6) ◽  
pp. 1439-1455
Author(s):  
Olumayokun A. Olajide ◽  
Satyajit D. Sarker
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Trials ◽  
Natural Products ◽  
Molecular Targets ◽  
Limited Success ◽  
Clinical Investigations ◽  
Anti Inflammatory

Abstract Alzheimer’s disease (AD) is the most common form of dementia and affects 44 million people worldwide. New emerging evidence from pre-clinical and clinical investigations shows that neuroinflammation is a major pathological component of AD suggesting that anti-inflammatory strategies are important in delaying the onset or slowing the progression of the disease. However, efforts to employ current anti-inflammatory agents in AD clinical trials have produced limited success. Consequently, there is a need to explore anti-inflammatory natural products, which target neuroinflammatory pathways relevant to AD pathogenesis. This review summarises important druggable molecular targets of neuroinflammation and presents classes of anti-neuroinflammatory natural products with potentials for preventing and reducing symptoms of AD.

scholarly journals Medicinal Plants and Biogenic Metal Oxide Nanoparticles: A Paradigm Shift to Treat Alzheimer’s Disease

Coatings ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 717
Author(s):  
Roby Gul ◽  
Hasnain Jan ◽  
Gul Lalay ◽  
Anisa Andleeb ◽  
Hazrat Usman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Natural Products ◽  
Medicinal Plants ◽  
Metal Oxide ◽  
Chromosomal Abnormalities ◽  
Metal Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Chemical Inhibition

Alzheimer’s disease (AD) is the most prevalent form of dementia. Improving the amount of acetylcholine in the brain is an efficient way to treat the illness. The global incidence of dementia is estimated to be as high as 50 million, and it is expected to increase every 20 years until 2040, resulting in a costly burden of disease. Early-life risk factors for pathology include genes, chromosomal abnormalities, head injury, insulin resistance, and inflammation. Potentially modifiable risk factors including obesity, diabetes, hypertension, and smoking are associated with Alzheimer’s disease (AD) and represent promising targets for intervention. The drugs currently being used to manage AD have various drawbacks. The chemical inhibition of cholinesterase enzymes is an effective technique for treating signal related neuropathology, and possible sources of compounds with these properties are natural products and biogenic metal oxide nanoparticles. There is a potential source of AChE and BChE inhibitors in the abundance of plants in nature, and natural goods appear to offer useful medications and templates for the development of other compounds. This dissertation represents a review of the literature on species of medicinal plants and nanomaterial related plants tested for their inhibitory action of AChE and BChE. Plant species and the plant-mediated metal oxide nanoparticles referred to are possible cholinesterase inhibitors and can assist researchers in their study of natural products that may be beneficial in the treatment of AD.

scholarly journals Two decades of new drug discovery and development for Alzheimer's disease

RSC Advances ◽  
2017 ◽  
Vol 7 (10) ◽  
pp. 6046-6058 ◽  
Author(s):  
Zhidong Liu ◽  
Aihua Zhang ◽  
Hui Sun ◽  
Ying Han ◽  
Ling Kong ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Discovery ◽  
Cognitive Function ◽  
Neurodegenerative Disease ◽  
Drug Discovery And Development ◽  
New Drug ◽  
Behavioral Abnormalities

Alzheimer's disease is a progressive and irreversible neurodegenerative disease, associated with a decreased cognitive function and severe behavioral abnormalities.

Therapeutic implications of anti-inflammatory natural products in Alzheimer’s disease

2019 ◽  
pp. 241-258 ◽  
Author(s):  
Satarupa Deb ◽  
Muhammed Khairujjaman Mazumder ◽  
Ankumoni Dutta ◽  
Banashree Chetia Phukan ◽  
Pallab Bhattacharya ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Natural Products ◽  
Therapeutic Implications ◽  
Anti Inflammatory
Sign in / Sign up

Export Citation Format

Share Document