scholarly journals Optimizing the SERS enhancement of a facile gold nanostar immobilized paper-based SERS substrate

RSC Advances ◽  
2017 ◽  
Vol 7 (27) ◽  
pp. 16264-16272 ◽  
Author(s):  
Shuai He ◽  
Jefri Chua ◽  
Eddie Khay Ming Tan ◽  
James Chen Yong Kah
Keyword(s):  
Enhancement Factor ◽  
Low Cost ◽  
Sers Substrate ◽  
Sers Enhancement ◽  
Gold Nanostar

Schematic of study to optimize the SERS enhancement factor of a low cost and facile gold nanostar (AuNS)-based paper-SERS substrate through optimizing the paper materials, immobilization strategies, and SERS acquisition conditions.

scholarly journals Label-free highly sensitive probe detection with novel hierarchical SERS substrates fabricated by nanoindentation and chemical reaction methods

2019 ◽  
Vol 10 ◽  
pp. 2483-2496
Author(s):  
Jingran Zhang ◽  
Tianqi Jia ◽  
Yongda Yan ◽  
Li Wang ◽  
Peng Miao ◽  
...  
Keyword(s):  
Ag Nanoparticles ◽  
Enhancement Factor ◽  
Low Cost ◽  
Hierarchical Structures ◽  
Production Method ◽  
Copper Surface ◽  
Sers Substrate ◽  
Label Free ◽  
Sers Substrates ◽  
Highly Sensitive

Nanostructures have been widely employed in surface-enhanced Raman scattering (SERS) substrates. Recently, in order to obtain a higher enhancement factor at a lower detection limit, hierarchical structures, including nanostructures and nanoparticles, appear to be viable SERS substrate candidates. Here we describe a novel method integrating the nanoindentation process and chemical redox reaction to machine a hierarchical SERS substrate. The micro/nanostructures are first formed on a Cu(110) plane and then Ag nanoparticles are generated on the structured copper surface. The effect of the indentation process parameters and the corrosion time in the AgNO3 solution on the Raman intensities of the SERS substrate with hierarchical structures are experimentally studied. The intensity and distribution of the electric field of single and multiple Ag nanoparticles on the surface of a plane and with multiple micro/nanostructures are studied with COMSOL software. The feasibility of the hierarchical SERS substrate is verified using R6G molecules. Finally, the enhancement factor using malachite green molecules was found to reach 5.089 × 109, which demonstrates that the production method is a simple, reproducible and low-cost method for machining a highly sensitive, hierarchical SERS substrate.

Gold nanostar substrates for SERS-based chemical sensing in the femtomolar regime

Nanoscale ◽  
2014 ◽  
Vol 6 (15) ◽  
pp. 8891-8899 ◽  
Author(s):  
A. S. D. S. Indrasekara ◽  
S. Meyers ◽  
S. Shubeita ◽  
L. C. Feldman ◽  
T. Gustafsson ◽  
...  
Keyword(s):  
Detection Limit ◽  
Enhancement Factor ◽  
Chemical Sensing ◽  
Gold Nanostars ◽  
Sers Enhancement ◽  
Gold Nanostar

A SERS sensor based on gold nanostars is described. The size and sharpness of the nanostar spikes are tuned to maximize sensitivity and SERS enhancement, yielding a detection limit of 10−15 M and an enhancement factor of 109. The effectiveness of the sensor is proven for both chemisorbed and physisorbed analytes under non-resonant conditions and its multiplexing capability is demonstrated.

Reassessing SERS enhancement factors: using thermodynamics to drive substrate design

2017 ◽  
Vol 205 ◽  
pp. 547-560 ◽  
Author(s):  
J. A. Guicheteau ◽  
A. Tripathi ◽  
E. D. Emmons ◽  
S. D. Christesen ◽  
Augustus W. Fountain
Keyword(s):  
Enhancement Factor ◽  
Sers Substrate ◽  
Us Army ◽  
Analytical Technique ◽  
Sers Substrates ◽  
Advantages And Disadvantages ◽  
Metal Interaction ◽  
Sers Enhancement ◽  
Aromatic Thiols ◽  
Underlying Mechanisms

Over the past 40 years fundamental and application research into Surface-Enhanced Raman Scattering (SERS) has been explored by academia, industry, and government laboratories. To date however, SERS has achieved little commercial success as an analytical technique. Researchers are tackling a variety of paths to help break through the commercial barrier by addressing the reproducibility in both the SERS substrates and SERS signals as well as continuing to explore the underlying mechanisms. To this end, investigators use a variety of methodologies, typically studying strongly binding analytes such as aromatic thiols and azarenes, and report SERS enhancement factor calculations. However a drawback of the traditional SERS enhancement factor calculation is that it does not yield enough information to understand substrate reproducibility, application potential with another analyte, or the driving factors behind the molecule–metal interaction. Our work at the US Army Edgewood Chemical Biological Center has focused on these questions and we have shown that thermodynamic principles play a key role in the SERS response and are an essential factor in future designs of substrates and applications. This work will discuss the advantages and disadvantages of various experimental techniques used to report SERS enhancement with planar SERS substrates and present our alternative SERS enhancement value. We will report on three types of analysis scenarios that all yield different information concerning the effectiveness of the SERS substrate, practical application of the substrate, and finally the thermodynamic properties of the substrate. We believe that through this work a greater understanding for designing substrates will be achieved, one that is based on both thermodynamic and plasmonic properties as opposed to just plasmonic properties. This new understanding and potential change in substrate design will enable more applications for SERS based methodologies including targeting molecules that are traditionally not easily detected with SERS due to the perceived weak molecule–metal interaction of substrates.

Validation of SERS enhancement factor measurements

2017 ◽  
Vol 49 (3) ◽  
pp. 462-471 ◽  
Author(s):  
R. Pilot ◽  
R. Bozio
Keyword(s):  
Enhancement Factor ◽  
Sers Enhancement

scholarly journals Commercial Gold Nanoparticles on Untreated Aluminum Foil: Versatile, Sensitive, and Cost-Effective SERS Substrate

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Kristina Gudun ◽  
Zarina Elemessova ◽  
Laura Khamkhash ◽  
Ekaterina Ralchenko ◽  
Rostislav Bukasov
Keyword(s):  
Gold Nanoparticles ◽  
Low Cost ◽  
Aluminum Foil ◽  
Cost Effective ◽  
Sers Substrate ◽  
Au Film ◽  
Response Range ◽  
Sers Detection ◽  
Film Substrate ◽  
Linear Response Range

We introduce low-cost, tunable, hybrid SERS substrate of commercial gold nanoparticles on untreated aluminum foil (AuNPs@AlF). Two or three AuNP centrifugation/resuspension cycles are proven to be critical in the assay preparation. The limits of detection (LODs) for 4-nitrobenzenethiol (NBT) and crystal violet (CV) on this substrate are about 0.12 nM and 0.19 nM, respectively, while maximum analytical SERS enhancement factors (AEFs) are about 107. In comparative assays LODs for CV measured on AuNPs@Au film and AuNPs@glass are about 0.35 nM and 2 nM, respectively. The LOD for melamine detected on AuNPs@ Al foil is 27 ppb with 3 orders of magnitude for linear response range. Overall, AuNPs@AlF demonstrated competitive performance in comparison with AuNPs@ Au film substrate in SERS detection of CV, NBT, and melamine. To check the versatility of the AuNPs@AlF substrate we also detected KNO3 with LODs of 0.7 mM and SERS EF around 2 × 103, which is on the same order with SERS EF reported for this compound in the literature.

Fabrication of low cost highly structured silver capped aluminium nanorods as SERS substrate for the detection of biological pathogens

2021 ◽  
Vol 32 (49) ◽  
pp. 495301
Author(s):  
Sathi Das ◽  
Laxman Prasad Goswami ◽  
Jampana Gayathri ◽  
Shubham Tiwari ◽  
Kanchan Saxena ◽  
...  
Keyword(s):  
Low Cost ◽  
Sers Substrate

A facile low-cost paper-based SERS substrate for label-free molecular detection

2019 ◽  
Vol 291 ◽  
pp. 369-377 ◽  
Author(s):  
Vo Thi Nhat Linh ◽  
Jungil Moon ◽  
ChaeWon Mun ◽  
Vasanthan Devaraj ◽  
Jin-Woo Oh ◽  
...  
Keyword(s):  
Molecular Detection ◽  
Low Cost ◽  
Sers Substrate ◽  
Label Free

scholarly journals Fabrication of nano/microstructures for SERS substrates using an electrochemical method

2020 ◽  
Vol 11 ◽  
pp. 1568-1576
Author(s):  
Jingran Zhang ◽  
Tianqi Jia ◽  
Xiaoping Li ◽  
Junjie Yang ◽  
Zhengkai Li ◽  
...  
Keyword(s):  
Electrochemical Method ◽  
Treatment Time ◽  
Low Cost ◽  
Three Dimensional ◽  
Electrochemical Process ◽  
Sers Substrate ◽  
Raman Intensity ◽  
Experimental Conditions ◽  
Sers Substrates ◽  
Au Film

Based on an electrochemical method, three-dimensional arrayed nanopore structures are machined onto a Mg surface. The structured Mg surface is coated with a thin gold (Au) film, which is used as a surface-enhanced Raman scattering (SERS) substrate. A rhodamine 6G (R6G) probe molecule is used as the detection agent for the SERS measurement. Different sizes of arrayed micro/nanostructures are fabricated by different treatment time using the electrochemical process. The topographies of these micro/nanostructures and the thickness of the Au film have an influence on the Raman intensity of the Mg substrate. Furthermore, when the thickness of Au film coating is held constant, the Raman intensity on the structured Mg substrates is about five times higher after a treatment time of 1 min when compared with other treatment times. The SERS enhancement factor ranges from 106 to 1.75 × 107 under these experimental conditions. Additionally, a 10−6 mol·L−1 solution of lysozyme was successfully detected using the Mg–Au nanopore substrates. Our low-cost method is reproducible, homogeneous, and suitable for the fabrication of SERS substrates.

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