scholarly journals The creation and characterisation of a National Compound Collection: the Royal Society of Chemistry pilot

2016 ◽  
Vol 7 (6) ◽  
pp. 3869-3878 ◽  
Author(s):  
David M. Andrews ◽  
Laura M. Broad ◽  
Paul J. Edwards ◽  
David N. A. Fox ◽  
Timothy Gallagher ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Royal Society ◽  
Historical Literature ◽  
Compound Collection ◽  
The Creation

We report the extraction of compound data from historical literature, making it chemically searchable. Evaluation by drug discovery groups reveals the utility of this approach.

Howard Florey - penicillin and after

1990 ◽  
Vol 44 (1) ◽  
pp. 136-137 ◽  
Keyword(s):  
Early Life ◽  
Royal Society ◽  
Full Account ◽  
Great Scientist ◽  
Oxford University ◽  
National University ◽  
The Creation ◽  
Oxford University Press

Trevor I. Williams, Howard Florey - penicillin and after . Oxford University Press, 1984. Pp. xiii + 404. £22.50. ISBN 0-19-858173-4. Soon after Florey’s death in 1978 there appeared an admirable biography by Gwyn Macfarlane ( Howard Florey - the making of a great scientist , Oxford, 1979). It gives a full account of Florey’s early life in Australia and England including the discovery and exploitation of penicillin, with shorter accounts of his later activities in relation to the creation of the Australian National University, his period as President of the Royal Society and his last post as Provost of Queen’s College, Oxford.

Some recent developments at the National Physical Laboratory

1962 ◽  
Vol 265 (1321) ◽  
pp. 141-160
Keyword(s):  
Royal Society ◽  
National Physical Laboratory ◽  
Industrial Research ◽  
Scientific Policy ◽  
Governing Body ◽  
Physical Laboratory ◽  
Recent Developments ◽  
The Creation

When the National Physical Laboratory was founded in 1900, the Royal Society was ‘invited to control the proposed institution and to nominate a governing body’. Since the Royal Society had agitated strongly for the creation of such a laboratory, this invitation was accepted, and although the National Physical Laboratory was incorporated into the Department of Scientific and Industrial Research when that body was created in 1917, the connexion between the Royal Society and the National Physical Laboratory is still very close on all matters of scientific policy.

scholarly journals 20 Years of Medicinal Chemistry – Always Look at the Bright Side (of Life)

2020 ◽  
Vol 74 (7) ◽  
pp. 549-560
Author(s):  
Christoph Boss
Keyword(s):  
Drug Discovery ◽  
Receptor Antagonist ◽  
Short Story ◽  
High Throughput Screening ◽  
Personal Perspective ◽  
Pivotal Phase ◽  
Insomnia Disorder ◽  
Compound Collection ◽  
Pulmonary Arterial ◽  
Personal Collection

This paper summarizes a personal perspective on key learnings from projects the author was involved in over the last 20 years. For example, the discovery of macitentan, the most successful molecule to date from this personal collection, marketed by J&J for the treatment of pulmonary arterial hypertension (PAH). [1] Then the discovery of ACT-462206, a dual orexin receptor antagonist for the treatment of insomnia disorder with a serendipitously short story from the screening hit to the drug [2] followed by the identification of daridorexant, another dual orexin receptor antagonist. Daridorexant successfully passed first pivotal phase 3 clinical trial in April 2020 for the treatment of insomnia disorder [3] ("Good things come to those who wait"). Finally, ACT-451840, an antimalarial drug with a novel mechanism of action, identified in the perfect collaboration between academia and industry. The compound is in phase 2 clinical development. [4] In addition, the importance of the screening compound collection is briefly discussed, as a key asset for drug discovery. The measures Idorsia implemented to obtain valuable hits from high-throughput screening (HTS) campaigns are elaborated. [5] Drug discovery is a multi-disciplinary business with unlimited exciting challenges asking for excessive optimism when tackling them in a playful manner.

The Society of Arts and Joseph Banks: a first step in London learned society

2007 ◽  
Vol 61 (3) ◽  
pp. 313-325 ◽  
Author(s):  
N.A Chambers
Keyword(s):  
Early Development ◽  
Royal Society ◽  
The Creation ◽  
At Home

Joseph Banks (1743–1820) was President of the Royal Society from 1778 to 1820, the longest anyone has served in that capacity, and during his prolonged tenure Banks was elected to numerous other societies at home and abroad. In the present paper Banks's membership of the Society of Arts and Manufactures is discussed, this being the first society to which he was ever elected in 1761. Of particular interest are the previously unexplained reasons for his withdrawal from the society in 1764, and his eventual re-election in 1791, this being the only example of Banks leaving and then rejoining a society. These events are investigated here. The creation, purpose and early development of the Society of Arts are also considered, as is its membership at a time when subscriptions were falling in the 1760s. Links with the Royal Society are described before, during and after this period of decline, and Joseph Banks's own contribution to the work of the Society of Arts is outlined.

Methodology and Apologetics: Thomas Sprat's History of the Royal Society

1980 ◽  
Vol 13 (1) ◽  
pp. 1-26 ◽  
Author(s):  
P. B. Wood
Keyword(s):  
Royal Society ◽  
Natural Philosophy ◽  
Self Perception ◽  
Social Basis ◽  
History Of ◽  
Novel Method ◽  
The Creation ◽  
Natural Philosophers

Central to Thomas Sprat's History of the Royal Society was the description and justification of the method adopted and advocated by the Fellows of the Society, for it was thought that it was their method which distinguished them from ancients, dogmatists, sceptics, and contemporary natural philosophers such as Descartes. The Fellows saw themselves as furthering primarily a novel method, rather than a system, of philosophy, and the History gave expression to this corporate self-perception. However, the History's description of their method was not necessarily accurate. Rather, as will be argued below, by a combination of subtle misrepresentation and selective exposition, Sprat portrayed a method which would further the aims of social and ecclesiastical stability and material prosperity, essential for the Royal Society since its continued existence depended upon the creation of a social basis for the institutionalized pursuit of natural philosophy. Some link had to be forged between the activities of the Society and the intellectual and social aspirations of the Restoration. To understand the intent and meaning of Sprat's History and the method there portrayed, we must therefore look to the institutional needs which it fulfilled.

The Arse Poetica of Thomas Hobbes: On the Composition and Reception of De Mirabilibus Pecci

2016 ◽  
Vol 1 (3) ◽  
pp. 305-357
Author(s):  
Jessica Wolfe
Keyword(s):  
Seventeenth Century ◽  
Royal Society ◽  
Literary Culture ◽  
Thomas Hobbes ◽  
Compelling Evidence ◽  
Experimental Science ◽  
Geological Processes ◽  
History Of ◽  
The Creation ◽  
Mock Epic

This article provides a two-part study of Thomas Hobbes’ De Mirabilibus Pecci, a Latin poem composed very early in his career. Part one examines the poem as a product of Hobbes’ participation in the recreational literary culture of Caroline England, in particular analysing the influence of mock-epic and burlesque traditions that would continue to shape Hobbes’ writings but also studying how the poem offers compelling evidence for his early preoccupation with the laws of motion, with geological processes such as the creation and erosion of stone formations, and with the philosophy of Lucretius. Part two recounts the extraordinary history of the poem’s reception in the last decades of the seventeenth century. The poem’s familiarity among Hobbes’ allies and adversaries alike helped to cement his reputation as a master of scoffing and drollery, as an opponent of the experimental science practiced by the Royal Society, and as a freethinker or atheist.

scholarly journals The Screening Compound Collection: A Key Asset for Drug Discovery

2017 ◽  
Vol 71 (10) ◽  
pp. 667-677 ◽  
Author(s):  
Christoph Boss ◽  
Julien Hazemann ◽  
Thierry Kimmerlin ◽  
Modest von Korff ◽  
Urs Lüthi ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Compound Collection
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