Control of particle uptake kinetics from particulate mesoporous silica films by cells through covalent linking of particles to the substrate – towards sequential drug delivery for tissue engineering applications

2016 ◽  
Vol 4 (47) ◽  
pp. 7669-7675 ◽  
Author(s):  
Oliver Wiltschka ◽  
Philipp Scheitenberger ◽  
Mika Lindén
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Stem Cells ◽  
Mesoporous Silica ◽  
Uptake Kinetics ◽  
Engineering Applications ◽  
Silica Films ◽  
Particle Uptake ◽  
High Interest ◽  
Sequential Release

A sequential release of biological cues is of high interest in tissue engineering applications, as both the proliferation and the differentiation of stem cells can be drugged.

Intrinsic porosity of calcium phosphate cements and its significance for drug delivery and tissue engineering applications

2009 ◽  
Vol 5 (7) ◽  
pp. 2752-2762 ◽  
Author(s):  
M. Espanol ◽  
R.A. Perez ◽  
E.B. Montufar ◽  
C. Marichal ◽  
A. Sacco ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Engineering Applications ◽  
Calcium Phosphate Cements

Regenerative Medicine: Applications and Development in Urology

2007 ◽  
Vol 74 (4) ◽  
pp. 197-205
Author(s):  
F. Pinto ◽  
A. Calarco ◽  
A. Brescia ◽  
E. Sacco ◽  
A. D'addessi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Regenerative Medicine ◽  
Cell Transplantation ◽  
Materials Science ◽  
Experimental Studies ◽  
Embryonic Stem ◽  
Human Embryos ◽  
Engineering Applications

Purpose Congenital abnormalities and acquired disorders can lead to organ damage and loss. Nowadays, transplantation represents the only effective treatment option. However, there is a marked decrease in the number of organ donors, which is even yearly worsening due to the population aging. The regenerative medicine represents a realistic option that allows to restore and maintain the normal functions of tissues and organs. This article reviews the principles of regenerative medicine and the recent advances with regard to its application to the genitourinary tract. Recent findings The field of regenerative medicine involves different areas of technology, such as tissue engineering, stem cells and cloning. Tissue engineering involves the field of cell transplantation, materials science and engineering in order to create functional replacement tissues. Stem cells and cloning permit the extraction of pluripotent, embryonic stem cells offering a potentially limitless source of cells for tissue engineering applications. Most current strategies for tissue engineering depend upon a sample of autologous cells from the patient's diseased organ. Biopsies from patients with extensive end-stage organ failure, however, may not yield enough normal cells. In these situations, stem cells are envisaged as being an alternative source. Stem cells can be derived from discarded human embryos (human embryonic stem cells), from fetal tissue or from adult sources (bone marrow, fat, skin). Therapeutic cloning offers a potentially limitless source of cells for tissue engineering applications. Regenerative medicine and tissue engineering scientists have increasingly applied the principles of cell transplantation, materials science and bioengineering to construct biological substitutes that will restore and maintain normal function in urological diseased and injured tissues such as kidney, ureter, bladder, urethra and penis. Conclusions Regenerative medicine offers several applications in acquired and congenital genitourinary diseases. Tissue engineering, stem cells and, mostly, cloning have been applied in experimental studies with excellent results. Few preliminary human applications have been developed with promising results.

Bioengineered Teeth from Cultured Rat Tooth Bud Cells

2004 ◽  
Vol 83 (7) ◽  
pp. 523-528 ◽  
Author(s):  
M.T. Duailibi ◽  
S.E. Duailibi ◽  
C.S. Young ◽  
J.D. Bartlett ◽  
J.P. Vacanti ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Engineering Applications ◽  
Adult Rat ◽  
Dental Tissues ◽  
Biodegradable Scaffolds ◽  
Bioengineered Tooth ◽  
Tooth Tissue

The recent bioengineering of complex tooth structures from pig tooth bud tissues suggests the potential for the regeneration of mammalian dental tissues. We have improved tooth bioengineering methods by comparing the utility of cultured rat tooth bud cells obtained from three- to seven-day post-natal (dpn) rats for tooth-tissue-engineering applications. Cell-seeded biodegradable scaffolds were grown in the omenta of adult rat hosts for 12 wks, then harvested. Analyses of 12-week implant tissues demonstrated that dissociated 4-dpn rat tooth bud cells seeded for 1 hr onto PGA or PLGA scaffolds generated bioengineered tooth tissues most reliably. We conclude that tooth-tissue-engineering methods can be used to generate both pig and rat tooth tissues. Furthermore, our ability to bioengineer tooth structures from cultured tooth bud cells suggests that dental epithelial and mesenchymal stem cells can be maintained in vitro for at least 6 days.

New core-shell hydroxyapatite/Gum-Acacia nanocomposites for drug delivery and tissue engineering applications

2018 ◽  
Vol 92 ◽  
pp. 685-693 ◽  
Author(s):  
Varun Prasath Padmanabhan ◽  
Ravichandran Kulandaivelu ◽  
Sankara Narayanan T.S. Nellaiappan
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Core Shell ◽  
Engineering Applications ◽  
Gum Acacia
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