Solid Dispersion Preparation by Different Methods to Improve Solubility & Dissolution Simvastatin

The improvement of a pure drug's solubility and dissolution rate in the treatment of hyperlipidemia. Simvastatin is a 5-percent absolute bioavailability selective competitive inhibitor of HMG Co-A reductase. For the selection of the carrier, a preliminary solubility investigation of solid dispersion was performed, and solid dispersion was made using Hydroxy Propyl Methyl Cellulose (HPMC) and gum acacia. Solid dispersion of medication with polymer was created and studied for solubility and in-vitro dissolution profile. Solid dispersion of drug with polymer has shown an increase in solubility and improved dissolution rate. On the obtained formulations, further FTIR, X-Ray, Scanning electron microscopy, and Differential scanning calorimetry experiments were conducted. The existence of amorphous form in a solid dispersion made with polymer in a 1:5 ratio is verified by characterization research. The research also showed that using a solid dispersion approach with Polymer, the dissolving rate of a pure medication may be significantly increased.

Formulation and evaluation of eco-friendly handmade herbal mosquito repellent cone

A mosquito belongs to the insect-family Culicidae, order Diptera, suborder Nematocera and class Insecta. Mosquito act as vector which carries many disease causing parasites and viruses. Preventing mosquito spread is immensely necessary to stop spread of various contagious diseases. Now days, uses of plant based mosquito repellent have increased as synthetic repellents contains many noxious chemicals which can cause possible toxicity like skin toxicity and causes swelling, redness, itching and many health problems. The herbal mosquito repellent cones were prepared by using saw dust, cow dung, gum acacia, neem powder, eucalyptus powder and lemon grass powder. Lemon grass has insecticidal property. Saw dust increases the combustion. Gum acacia act as binder. Cow dung shows antioxidant and mosquito repellent property. Neem has mosquito repellent property. Herbal mosquito repellent cone were prepared by hand rolling method. The evaluation parameters of herbal mosquito repellent cone contain burning time (min), smoke visibility, odor, irritation test, ash weight (g.) and mosquito repellent activity. The formulation LNC containing lemon grass powder along with neem powder and cow dung in equal ratio shows best activity and maximum effectiveness in reducing mosquito number in comparison with all other formulations. In present study, the powders used in formulation were herbal based and eco-friendly and producing no side-effect on use. Here an attempt has been made to find out the novel formulation of different herbal plant powders containing alone and with combination for mosquito repellent cone.

Evaluation of the antipyretic and anti-inflammatory potential of aqueous fruit pulp extract of Terminalia bellirica (Combretaceae) v1

Introduction: Inflammation and fever are common clinical manifestations of many deadly diseases. Members of the genus Terminalia were discovered to have the ability to alleviate inflammation and fever. As a result, this research examined the in-vivoanti-inflammatory and antipyretic properties of aqueous fruit pulp extract of Terminalia bellirica in mice and rats. Methods: The acute and subacute anti-inflammatory effects of the plant were evaluated using Carrageenan-induced paw edema. The antipyretic effect of the plant was evaluated using Baker’s yeast-induced pyrexia model. The extract was given to three experimental groups (9 mg/kg, 18 mg/kg, and 36 mg/kg), with Indomethacin 10 mg/kg and Paracetamol 100 mg/kg servings as positive controls for anti-inflammatory and antipyretic tests, respectively. Negative controls for anti-inflammatory and antipyretic testing were with 1% Gum acacia suspension of 3 ml/kg and 10 ml/kg, respectively. Results: In acute anti-inflammatory activity tests, using the Carrageenan paw edema model, TB18 and TB36 displayed a significant reduction in mean paw edema (P<0.01). In subacute anti-inflammatory activity tests, TB36 displayed a significant reduction in mean paw edema (P<0.01). In Baker’s yeast-induced pyrexia tests, the rectal temperature reduced significantly (P<0.0001) in all experimental groups. Conclusion: In summary, the findings of this study showed that the extract displayed significant anti-inflammatory and antipyretic characteristics in mice and rats accordingly. Keywords: Carrageenan,fever, inflammation, yeast

Assessment of free-radical scavenging and anti-bacterial potential of Thymol conjugated with Gum Acacia-Chitosan copolymeric nanoformulation

This study details with thymol loaded on anionic copolymeric (Gum Acacia-Chitosan) nanoformulation prepared using ionic gelation to further enhance its therapeutic effectiveness. Optimized nanoparticles of 10:1 ratio (Gum Acacia:Chitosan) having entrapmentefficiency of 97% and mean hydrodynamic diameter of 172 nm (obtained using DLS) were characterized and in vitro examined for drug release effect, antioxidant potential and antibacterial activity. Zeta potential reading (-31.4 mV) confirmed optimized nanoformulation as stable and Electron-microscopy affirmed spherical morphology. FTIR analysis revealed entrapment as well as chemical-conjugation of thymol in polymer matrices. Thymol availability lasting more than 24 hours was verified in vitro by drug release experiments. Synthesized nanoformulation demonstrated superior antioxidant and antibacterial activity which may be attributable to its anionic charge, slow sustained release and synergistic effect provided by copolymers. Hence this investigation suggests control-release strategy using these copolymers for further utilization of thymol as natural therapeutic molecule by overcoming its solubility, stability and oxidation problems.

Design of Solid Dosage Form using Isolated Mucilage from Cassia fistula

The present study was aimed to isolate and characterize mucilage obtained from the leaves of Amaltas (Cassia fistula) and to check the binding efficiency by comparing with gum acacia. Isolation of mucilage was done by hot maceration process and investigated for various physicochemical characterization and in vitro dissolution profile to check mucilage as a binding agent. Different batches (KF1 – KF4) of paracetamol tablets of different concentration of mucilage (3%, 5%, 10% and 15% w/v) were prepared by wet granulation method. All the parameters of uncoated tablets were performed and compared with tablets prepared with gum acacia in the same concentration. SEM indicated irregular shape and size of mucilage particles. Good thermal stability of mucilage was indicated by TGA and amorphous nature by P-XRD and DSC. FTIR and NMR confirmed the presence of polysaccharide. From the results, formulations KF2 and KF3 were found to be optimized as they showed 99% drug release within 20-25 min and better results were obtained when compared with existing binder gum acacia. According to the studies, mucilage isolated from the leaves of Cassia fistula showed interesting results suggesting that amaltas mucilage can be used as a promising natural excipient (binder) in preparation of conventional uncoated tablet dosage form.