Metal-free intramolecular amino-acyloxylation of 2-aminostyrene with carboxylic acid for the synthesis of 3-acyloxyl indolines in water

2017 ◽  
Vol 19 (9) ◽  
pp. 2076-2079 ◽  
Author(s):  
Liyan Liu ◽  
Zhiyong Wang
Keyword(s):  
Carboxylic Acid ◽  
Free Amino ◽  
Metal Free

A metal-free amino-acyloxylation of 2-aminostyrene was developed for the synthesis of 3-acyloxyl indolines.

Metal-free amino-controlled electrochemical intramolecular C–O and C–N couplings by site-selective activation of aryl C–N and C–O bonds

2021 ◽  
Author(s):  
Mu-Jia Luo ◽  
Gui-Fen Lv ◽  
Yang Li ◽  
Jin-Heng Li
Keyword(s):  
Free Amino ◽  
Selective Activation ◽  
Metal Free ◽  
Site Selective

Metal-free amino-assisted electrochemical intramolecular C–O or C–N couplings of amino-2-(2-aminoaryl)phenols are described.

scholarly journals Fast Surface Immobilization of Native Proteins through Metal-Free Amino-yne Click Bioconjugation

2019 ◽  
Author(s):  
Yiru Zhang ◽  
Jianlei Shen ◽  
Rong Hu ◽  
Shi Xiujuan ◽  
Xianglong Hu ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Free Amino ◽  
Surface Immobilization ◽  
Ethynyl Group ◽  
Metal Free ◽  
Native Proteins ◽  
Functionalized Surfaces ◽  
Bulk Solutions

In this work, we use a spontaneous and catalyst-free amino-yne click bioconjugation to generate activated ethynyl group functionalized surfaces for fast immobilizing native proteins and cells. Biomolecules, such as bovine serum albumin (BSA), human IgG and peptide of C(RGDfK), could be covalently immobilized on the surfaces in as short as 30 min. Notably, the bioactivity of the anchored biomolecules remain intact, which is verified by efficiently capturing target antibodies and cells from the bulk solutions. This strategy represents an alternative for highly efficient surface biofunctionalization.

scholarly journals Metal Free Amino-Oxidation of Electron Rich Alkenes Mediated by an Oxoammonium Salt

2020 ◽  
Author(s):  
Alexandra Millimaci ◽  
Rowan Meador ◽  
Sara Dampf ◽  
John D. Chisholm
Keyword(s):  
Transition Metal ◽  
Solvent Effects ◽  
Free Amino ◽  
Oxidation Products ◽  
Direct Transition ◽  
Metal Free ◽  
Mild Conditions ◽  
Relative Stereochemistry ◽  
Oxoammonium Salt

<div> <div> <div> <p>4-Acetamido-2,2,6,6-tetramethyl-1-oxopiperidinium tetrafluoroborate (Bobbitt’s salt) effectively activates electron rich alkenes and promotes the addition of anilines. This transformation provides a direct, transition metal free method for amino-oxidation of alkenes under mild conditions. The relative stereochemistry of the amino-oxidation is influenced by solvent effects, with both the syn and anti amino-oxidation products being accessible from identical starting materials. </p> </div> </div> </div>

Fluorescein Analogue Xanthene-9-Carboxylic Acid: A Transition-Metal-Free CO Releasing Molecule Activated by Green Light

2013 ◽  
Vol 15 (17) ◽  
pp. 4552-4555 ◽  
Author(s):  
Lovely Angel Panamparambil Antony ◽  
Tomáš Slanina ◽  
Peter Šebej ◽  
Tomáš Šolomek ◽  
Petr Klán
Keyword(s):  
Carboxylic Acid ◽  
Transition Metal ◽  
Green Light ◽  
Metal Free

Synthesis and singlet oxygen production of azaphthalocyanines bearing functional derivatives of carboxylic acid

2006 ◽  
Vol 10 (02) ◽  
pp. 122-131 ◽  
Author(s):  
Zbynek Musil ◽  
Petr Zimcik ◽  
Miroslav Miletin ◽  
Kamil Kopecky ◽  
Marek Link ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Singlet Oxygen ◽  
Hexanoic Acid ◽  
Oxygen Production ◽  
Metal Free ◽  
Dye Sensitized ◽  
Structure Activity ◽  
Functional Derivatives ◽  
Derivatives Of ◽  
Free Magnesium

New metal-free, magnesium and zinc azaphthalocyanines ( AzaPc ) were prepared from 6-(3-tert-butylsulfany1-5,6-dicyanopyrazine-2-ylamino)hexanoic acid and its butylester and N,N-diethylamide. Their singlet oxygen production was measured by a dye-sensitized photooxidation of 1,3-diphenylisobenzofuran ( DPBF ) and ΦΔ values were calculated. It was found that the presence of carboxylic acid in the structure of AzaPc decreases their singlet oxygen production. Singlet oxygen activity of the newly prepared compounds (containing mixed alkylamino and alkylsulfanyl peripheral substituents) lies between purely alkylsulfanyl and alkylamino derivatives of AzaPc . This fact further supports previously proposed structure-activity relationships, where alkylsulfanyl derivatives belong to the best singlet oxygen producers while the presence of alkylamino substituents in the structure rapidly decreases their photodynamic properties.

A practical metal-free homolytic aromatic alkylation protocol for the synthesis of 3-(pyrazin-2-yl)bicyclo[1.1.1]pentane-1-carboxylic acid

2016 ◽  
Vol 14 (40) ◽  
pp. 9485-9489 ◽  
Author(s):  
Navanita T. Thirumoorthi ◽  
Vikrant A. Adsool
Keyword(s):  
Carboxylic Acid ◽  
Building Block ◽  
Medicinal Chemistry ◽  
Biological Study ◽  
Metal Free

As a part of our ongoing synthetic quest to expand the frontiers of contemporary medicinal chemistry, we now report an expedient synthesis of a potentially useful bicyclo[1.1.1]pentane building block, 3-(pyrazin-2-yl)bicyclo[1.1.1]pentane-1-carboxylic acid. This report also showcases the application of this motif as a “spacer” probe in a biological study.

Metal-Free O -Arylation of Carboxylic Acid by Active Diaryliodonium(III) Intermediates Generated in situ from Iodosoarenes

2017 ◽  
Vol 359 (20) ◽  
pp. 3503-3508 ◽  
Author(s):  
Toshifumi Dohi ◽  
Daichi Koseki ◽  
Kohei Sumida ◽  
Kana Okada ◽  
Serina Mizuno ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Metal Free

Metal-Free Synthesis of Benzothiazoles from Disulfides of 2-Aminobenzenethiol and Carboxylic Acid via PCl3-Promoted Tandem Reaction

Heterocycles ◽  
2015 ◽  
Vol 91 (9) ◽  
pp. 1723 ◽  
Author(s):  
Ning Zhu ◽  
Guangyan Du ◽  
Limin Han ◽  
Hailong Hong ◽  
Quanling Suo
Keyword(s):  
Carboxylic Acid ◽  
Tandem Reaction ◽  
Metal Free

Formal α-trifluoromethylthiolation of carboxylic acid derivatives via N-acyl pyrazoles

2020 ◽  
Vol 56 (20) ◽  
pp. 3073-3076 ◽  
Author(s):  
Francesca Franco ◽  
Sara Meninno ◽  
Maurizio Benaglia ◽  
Alessandra Lattanzi
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
One Pot ◽  
Metal Free

A direct and general one-pot approach to α-trifluoromethylthiolated amides, esters and carboxylic acids has been successfully developed under mild, catalytic and metal-free conditions.

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