A practical metal-free homolytic aromatic alkylation protocol for the synthesis of 3-(pyrazin-2-yl)bicyclo[1.1.1]pentane-1-carboxylic acid
2016 ◽
Vol 14
(40)
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pp. 9485-9489
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As a part of our ongoing synthetic quest to expand the frontiers of contemporary medicinal chemistry, we now report an expedient synthesis of a potentially useful bicyclo[1.1.1]pentane building block, 3-(pyrazin-2-yl)bicyclo[1.1.1]pentane-1-carboxylic acid. This report also showcases the application of this motif as a “spacer” probe in a biological study.
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2018 ◽
Vol 59
(49)
◽
pp. 4320-4322
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2006 ◽
Vol 10
(02)
◽
pp. 122-131
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