scholarly journals Molecular modeling study, synthesis and biological evaluation of combretastatin A-4 analogues as anticancer agents and tubulin inhibitors

MedChemComm ◽  
2018 ◽  
Vol 9 (2) ◽  
pp. 316-327 ◽  
Author(s):  
Yang Ping Quan ◽  
Li Ping Cheng ◽  
Tian Chi Wang ◽  
Wan Pang ◽  
Fan Hong Wu ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Anticancer Agents ◽  
Hepg2 Cells ◽  
Binding Mode ◽  
Biological Evaluation ◽  
Tubulin Inhibitors ◽  
Molecular Modeling Study ◽  
Synthesis And Biological Evaluation ◽  
Modeling Study

Compound 13a, more effective than CA-4 against HepG2 cells and tubulin, and the proposed binding mode for 13a.

Design, synthesis and biological evaluation of estradiol-PEG-linked platinum(II) hybrid molecules: Comparative molecular modeling study of three distinct families of hybrids

Steroids ◽  
2011 ◽  
Vol 76 (1-2) ◽  
pp. 94-103 ◽  
Author(s):  
Josée Provencher-Mandeville ◽  
Chhanda Debnath ◽  
Sanat K. Mandal ◽  
Valérie Leblanc ◽  
Sophie Parent ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Molecular Modeling Study ◽  
Hybrid Molecules ◽  
Synthesis And Biological Evaluation ◽  
Modeling Study

Synthesis and biological evaluation of new curcumin analogues as antioxidant and antitumor agents: Molecular modeling study

2015 ◽  
Vol 101 ◽  
pp. 584-594 ◽  
Author(s):  
Said M. Bayomi ◽  
Hassan A. El-Kashef ◽  
Mahmoud B. El-Ashmawy ◽  
Magda N.A. Nasr ◽  
Magda A. El-Sherbeny ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Antitumor Agents ◽  
Biological Evaluation ◽  
Curcumin Analogues ◽  
Molecular Modeling Study ◽  
Synthesis And Biological Evaluation ◽  
Modeling Study

Synthesis, biological evaluation and molecular modeling study of pyrazole derivatives as selective COX-2 inhibitors and anti-inflammatory agents

2014 ◽  
Vol 56 ◽  
pp. 8-15 ◽  
Author(s):  
Ashish Kumar Tewari ◽  
Ved Prakash Singh ◽  
Pratima Yadav ◽  
Garima Gupta ◽  
Amit Singh ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Biological Evaluation ◽  
Pyrazole Derivatives ◽  
Molecular Modeling Study ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
Cox 2 Inhibitors ◽  
Modeling Study

Thiazolo[4,5- d ]pyridazine analogues as a new class of dihydrofolate reductase (DHFR) inhibitors: Synthesis, biological evaluation and molecular modeling study

2017 ◽  
Vol 74 ◽  
pp. 228-237 ◽  
Author(s):  
Menna A. Ewida ◽  
Dalal A. Abou El Ella ◽  
Deena S. Lasheen ◽  
Heba A. Ewida ◽  
Yomna I. El-Gazzar ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Dihydrofolate Reductase ◽  
Biological Evaluation ◽  
New Class ◽  
Molecular Modeling Study ◽  
Dhfr Inhibitors ◽  
Modeling Study

Synthesis, biological evaluation and molecular modeling study of 2-amino-3,5-disubstituted-pyrazines as Aurora kinases inhibitors

2020 ◽  
Vol 28 (5) ◽  
pp. 115351 ◽  
Author(s):  
Yong-Xin Bo ◽  
Rong Xiang ◽  
Yu Xu ◽  
Shu-Yi Hao ◽  
Xing-Rong Wang ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Biological Evaluation ◽  
Aurora Kinases ◽  
Molecular Modeling Study ◽  
Modeling Study

Thiadiazolodiazepine analogues as a new class of neuromuscular blocking agents: Synthesis, biological evaluation and molecular modeling study

2017 ◽  
Vol 126 ◽  
pp. 15-23 ◽  
Author(s):  
Hussein I. El-Subbagh ◽  
Adel S. El-Azab ◽  
Ghada S. Hassan ◽  
Shahenda M. El-Messery ◽  
Alaa A.-M. Abdel-Aziz ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Biological Evaluation ◽  
Neuromuscular Blocking ◽  
Neuromuscular Blocking Agents ◽  
New Class ◽  
Blocking Agents ◽  
Molecular Modeling Study ◽  
Modeling Study

Synthesis, biological evaluation and molecular modeling study of some new methoxylated 2-benzylthio-quinazoline-4( 3H )-ones as nonclassical antifolates

2016 ◽  
Vol 26 (19) ◽  
pp. 4815-4823 ◽  
Author(s):  
Shahenda M. El-Messery ◽  
Ghada S. Hassan ◽  
Mahmoud N. Nagi ◽  
El-Sayed E. Habib ◽  
Sarah T. Al-Rashood ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Biological Evaluation ◽  
Molecular Modeling Study ◽  
Modeling Study
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