Single-chain nanoparticles containing sequence-defined segments: using primary structure control to promote secondary and tertiary structures in synthetic protein mimics

2017 ◽  
Vol 8 (38) ◽  
pp. 5829-5835 ◽  
Author(s):  
J. P. Cole ◽  
J. J. Lessard ◽  
K. J. Rodriguez ◽  
A. M. Hanlon ◽  
E. K. Reville ◽  
...  
Keyword(s):  
Primary Structure ◽  
Multicomponent Reactions ◽  
Single Chain ◽  
Cross Link ◽  
Tertiary Structures ◽  
Structure Control ◽  
Protein Mimics ◽  
Multiple Protein ◽  
Synthetic Protein

We investigated intra-chain multicomponent reactions to synthesize single-chain nanoparticles (SCNP) containing sequence-defined segments at each cross-link, creating materials featuring multiple protein-inspired elements.

Structure Control of Synthetic Bilayer Membranes from Single-Chain Amphiphiles Containing the Schiff Base Segment

1996 ◽  
Vol 178 (2) ◽  
pp. 703-713 ◽  
Author(s):  
Yingqiu Liang ◽  
Lixin Wu ◽  
Yongchi Tian ◽  
Zhiqiang Zhang ◽  
Huidong Chen
Keyword(s):  
Schiff Base ◽  
Single Chain ◽  
Bilayer Membranes ◽  
Structure Control

Structure Control of Synthetic Bilayer Membranes from Single-Chain Amphiphiles Containing the Schiff Base Segment

1996 ◽  
Vol 178 (2) ◽  
pp. 714-719 ◽  
Author(s):  
Yingqiu Liang ◽  
Zhiqiang Zhang ◽  
Lixin Wu ◽  
Yongchi Tian ◽  
Huidong Chen
Keyword(s):  
Schiff Base ◽  
Single Chain ◽  
Bilayer Membranes ◽  
Structure Control

scholarly journals Primary structure and origin of schistosomin, an anti-gonadotropic neuropeptide of the pond snail Lymnaea stagnalis

1991 ◽  
Vol 279 (3) ◽  
pp. 837-842 ◽  
Author(s):  
P L Hordijk ◽  
H D F H Schallig ◽  
R H M Ebberink ◽  
M de Jong-Brink ◽  
J Joosse
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Primary Structure ◽  
Lymnaea Stagnalis ◽  
Sequence Similarity ◽  
Infected Snail ◽  
Chain Molecule ◽  
Pond Snail ◽  
Single Chain ◽  
The Central Nervous System

In the pond snail Lymnaea stagnalis infected with the schistosome parasite Trichobilharzia ocellata, a peptide called schistosomin is released from the central nervous system, which counteracts the bioactivity of a number of gonadotropic hormones. This leads to inhibition of the reproductive activities of the infected snail. In order to determine the structure of schistosomin, the neuropeptide was purified from the central nervous system using gel-permeation chromatography and reverse-phase h.p.l.c. The complete primary structure of the peptide was determined by N-terminal sequencing and peptide mapping. Schistosomin is a single-chain molecule of 79 amino acids with a molecular mass of 8738 Da. The peptide contains eight cysteine residues which may give rise to four intramolecular disulphide bridges that fold the peptide into a stable globular structure. A database search did not reveal any known peptides that show significant sequence similarity to schistosomin. By means of immunocytochemistry, the peptide was shown to be localized in the growth-controlling neurosecretory light green cells, which are located in the cerebral ganglia of the central nervous system of Lymnaea. In addition to schistosomin, these neurons are known to produce various insulin-related peptides.

Tailoring single chain polymer nanoparticle thermo-mechanical behavior by cross-link density

Soft Matter ◽  
2017 ◽  
Vol 13 (15) ◽  
pp. 2808-2816 ◽  
Author(s):  
Suwon Bae ◽  
Or Galant ◽  
Charles E. Diesendruck ◽  
Meredith N. Silberstein
Keyword(s):  
Mechanical Behavior ◽  
Single Chain ◽  
Cross Link ◽  
Chain Polymer ◽  
Polymer Nanoparticle ◽  
Link Density ◽  
Cross Link Density

Modular design of synthetic protein mimics. Characterization of the helical conformation of a 13-residue peptide in crystals

Biochemistry ◽  
1989 ◽  
Vol 28 (16) ◽  
pp. 6696-6701 ◽  
Author(s):  
Isabella L. Karle ◽  
Judith L. Flippen-Anderson ◽  
K. Uma ◽  
P. Balaram
Keyword(s):  
Modular Design ◽  
Helical Conformation ◽  
Protein Mimics ◽  
Synthetic Protein
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