Kinetics study of heterogeneous continuous-flow nitration of trifluoromethoxybenzene

2018 ◽  
Vol 3 (3) ◽  
pp. 379-387 ◽  
Author(s):  
Zhenghui Wen ◽  
Mei Yang ◽  
Shuainan Zhao ◽  
Feng Zhou ◽  
Guangwen Chen
Keyword(s):  
Continuous Flow ◽  
Kinetic Data ◽  
Large Scale ◽  
Process Development ◽  
Kinetics Study ◽  
Large Scale Synthesis

Trifluoromethoxybenzene (TFMB) nitration was studied in a microreactor, furnishing kinetic data that promoted the process development of large-scale synthesis.

Optimized Large Scale Synthesis of Phosphorothioate Oligonucleotides on PS-PEG Supports

1997 ◽  
Vol 52 (1) ◽  
pp. 110-116
Author(s):  
Michael Gerster ◽  
Martin Maier ◽  
Nils Clausen ◽  
Jens Schewitz ◽  
Ernst Bayer
Keyword(s):  
Gel Electrophoresis ◽  
Continuous Flow ◽  
Large Scale ◽  
Electrospray Mass Spectrometry ◽  
Small Scale ◽  
Batch Mode ◽  
Crucial Step ◽  
Capillary Gel Electrophoresis ◽  
Phosphoramidite Chemistry ◽  
Large Scale Synthesis

Sulphurization is a crucial step during synthesis of phosphorothioate oligonucleotides. Insufficient reaction leads to inhomogeneous products with phosphodiester defects and subsequently to destabilization of the oligomers in biological media. To achieve a maximum extent of sulphur incorporation, various sulphurizing agents have been investigated. Solely, the use of Beaucage reagent provided satisfactory results on PS-PEG supports. Based on our investigations in small scale synthesis (1 μmol) with continuous-flow technique, upscaling to the 0.1-0.25 mmolar range has been achieved using a peptide synthesizer. The syntheses were performed in batch mode with standard phosphoramidite chemistry. Additionally, large scale synthesis of a phosphodiester oligonucleotide has been carried out on PS-PEG with optimized protocols and compared to small scale synthesis on different supports. Products were analysed by 31P NMR, capillary gel electrophoresis and electrospray mass spectrometry. An extent of sulphurization of 99% and coupling effiencies of more than 99% were obtained and the products proved to have similar purity compared to small scale syntheses on CPG

Process Development and Large-Scale Synthesis of a PDE4 Inhibitor

2006 ◽  
Vol 10 (1) ◽  
pp. 36-45 ◽  
Author(s):  
David A. Conlon ◽  
Antoinette Drahus-Paone ◽  
Guo-Jie Ho ◽  
Brenda Pipik ◽  
Roy Helmy ◽  
...  
Keyword(s):  
Large Scale ◽  
Process Development ◽  
Pde4 Inhibitor ◽  
Large Scale Synthesis

Process Development and Large-Scale Synthesis of BTK Inhibitor BIIB068

2020 ◽  
Vol 24 (6) ◽  
pp. 1199-1206
Author(s):  
Chaomin Li ◽  
Lloyd Franklin ◽  
Robbie Chen ◽  
Tamera Mack ◽  
Michael Humora ◽  
...  
Keyword(s):  
Large Scale ◽  
Process Development ◽  
Btk Inhibitor ◽  
Large Scale Synthesis

ChemInform Abstract: Process Development and Large-Scale Synthesis of NK1Antagonist.

ChemInform ◽  
2008 ◽  
Vol 39 (32) ◽  
Author(s):  
Ichiro Araya ◽  
Shintaro Kanazawa ◽  
Hiroyuki Akita
Keyword(s):  
Large Scale ◽  
Process Development ◽  
Large Scale Synthesis

scholarly journals Process Development and Large-Scale Synthesis of NK1 Antagonist

2008 ◽  
Vol 56 (2) ◽  
pp. 176-180 ◽  
Author(s):  
Ichiro Araya ◽  
Shintaro Kanazawa ◽  
Hiroyuki Akita
Keyword(s):  
Large Scale ◽  
Process Development ◽  
Nk1 Antagonist ◽  
Large Scale Synthesis

Process Development of a Large-Scale Synthesis of TKA731:  A Tachykinin Receptor Antagonist

2004 ◽  
Vol 8 (3) ◽  
pp. 330-340 ◽  
Author(s):  
Mahavir Prashad ◽  
Denis Har ◽  
Bin Hu ◽  
Hong-Yong Kim ◽  
Michael J. Girgis ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Large Scale ◽  
Process Development ◽  
Tachykinin Receptor ◽  
Large Scale Synthesis

Process Development and Large-Scale Synthesis of a c-Met Kinase Inhibitor

2010 ◽  
Vol 14 (4) ◽  
pp. 849-858 ◽  
Author(s):  
Gavin W. Stewart ◽  
Karel M. J. Brands ◽  
Sarah E. Brewer ◽  
Cameron J. Cowden ◽  
Antony J. Davies ◽  
...  
Keyword(s):  
Large Scale ◽  
Kinase Inhibitor ◽  
Process Development ◽  
Large Scale Synthesis

Large-scale synthesis of high quality InP quantum dots in a continuous flow-reactor under supercritical conditions

2015 ◽  
Vol 26 (8) ◽  
pp. 085604 ◽  
Author(s):  
Christian Ippen ◽  
Benjamin Schneider ◽  
Christopher Pries ◽  
Stefan Kröpke ◽  
Tonino Greco ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Continuous Flow ◽  
Large Scale ◽  
Flow Reactor ◽  
High Quality ◽  
Supercritical Conditions ◽  
Continuous Flow Reactor ◽  
Large Scale Synthesis ◽  
Inp Quantum Dots
Sign in / Sign up

Export Citation Format

Share Document