A pH-sensitive guar gum-grafted-lysine-β-cyclodextrin drug carrier for the controlled release of 5-flourouracil into cancer cells

2018 ◽  
Vol 6 (10) ◽  
pp. 1519-1530 ◽  
Author(s):  
Rajendran Amarnath Praphakar ◽  
Murugan Jeyaraj ◽  
Sivaraj Mehnath ◽  
Akon Higuchi ◽  
Deepalekshmi Ponnamma ◽  
...  
Keyword(s):  
Controlled Release ◽  
Cancer Cells ◽  
Guar Gum ◽  
Drug Carrier ◽  
Ph Sensitive ◽  
Relative Ease ◽  
Biomedical Systems

The physiological environment is a crucial factor in biomedical systems, which can be regulated with relative ease both in vitro and in vivo.

scholarly journals In vitro and in vivo evaluation of guar gum matrix tablets for oral controlled release of water-soluble diltiazem hydrochloride

2005 ◽  
Vol 6 (1) ◽  
pp. E14-E21 ◽  
Author(s):  
Saleh M. Al-Saidan ◽  
Yellela S. R. Krishnaiah ◽  
S. Patro ◽  
Vemulapalli Satyanaryana
Keyword(s):  
Controlled Release ◽  
Guar Gum ◽  
Water Soluble ◽  
Matrix Tablets ◽  
Diltiazem Hydrochloride ◽  
In Vivo Evaluation

Preparation and in vitro controlled release behavior of a novel pH-sensitive drug carrier for colon delivery

2008 ◽  
Vol 62 (2) ◽  
pp. 183-193 ◽  
Author(s):  
Dong-Ying Xu ◽  
Guang-Ji Li ◽  
Zheng-Fu Liao ◽  
Xiao-Hong He
Keyword(s):  
Controlled Release ◽  
Drug Carrier ◽  
Ph Sensitive ◽  
Release Behavior ◽  
Colon Delivery

Double targeting and aptamer-assisted controlled release delivery of epirubicin to cancer cells by aptamers-based dendrimer in vitro and in vivo

2016 ◽  
Vol 102 ◽  
pp. 152-158 ◽  
Author(s):  
Seyed Mohammad Taghdisi ◽  
Noor Mohammad Danesh ◽  
Mohammad Ramezani ◽  
Parirokh Lavaee ◽  
Seyed Hamid Jalalian ◽  
...  
Keyword(s):  
Controlled Release ◽  
Cancer Cells

Smart aptamer-modified calcium carbonate nanoparticles for controlled release and targeted delivery of epirubicin and melittin into cancer cells in vitro and in vivo

2019 ◽  
Vol 45 (4) ◽  
pp. 603-610 ◽  
Author(s):  
Rezvan Yazdian-Robati ◽  
Atefeh Arab ◽  
Mohammad Ramezani ◽  
Houshang Rafatpanah ◽  
Amirhossein Bahreyni ◽  
...  
Keyword(s):  
Calcium Carbonate ◽  
Controlled Release ◽  
Cancer Cells ◽  
Targeted Delivery

In-vitro and In-vivo Pharmacokinetic Evaluation of Guar Gum-Eudragit® S100 Based Colon-targeted Spheroids of Sulfasalazine Co-administered with Probiotics

2018 ◽  
Vol 15 (3) ◽  
pp. 367-387 ◽  
Author(s):  
Abhinav Sharma ◽  
Bimlesh Kumar ◽  
Sachin Kumar Singh ◽  
Monica Gulati ◽  
Yogyata Vaidya ◽  
...  
Keyword(s):  
Guar Gum ◽  
Pharmacokinetic Evaluation

In Vitro and In Vivo Antitumor Efficacy of Docetaxel and Sorafenib Combination in Human Pancreatic Cancer Cells

2010 ◽  
Vol 999 (999) ◽  
pp. 1-11
Author(s):  
P. Ulivi ◽  
C. Arienti ◽  
W. Zoli ◽  
M. Scarsella ◽  
S. Carloni ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Antitumor Efficacy ◽  
Human Pancreatic Cancer ◽  
Pancreatic Cancer Cells

A Novel Triazole Derivative Drug Presenting In Vitro and In Vivo Anticancer Properties

2018 ◽  
Vol 18 (17) ◽  
pp. 1483-1493
Author(s):  
Ricardo Imbroisi Filho ◽  
Daniel T.G. Gonzaga ◽  
Thainá M. Demaria ◽  
João G.B. Leandro ◽  
Dora C.S. Costa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Hepatic Function ◽  
Anticancer Properties ◽  
Mcf 7

Background: Cancer is a major cause of death worldwide, despite many different drugs available to treat the disease. This high mortality rate is largely due to the complexity of the disease, which results from several genetic and epigenetic changes. Therefore, researchers are constantly searching for novel drugs that can target different and multiple aspects of cancer. Experimental: After a screening, we selected one novel molecule, out of ninety-four triazole derivatives, that strongly affects the viability and proliferation of the human breast cancer cell line MCF-7, with minimal effects on non-cancer cells. The drug, named DAN94, induced a dose-dependent decrease in MCF-7 cells viability, with an IC50 of 3.2 ± 0.2 µM. Additionally, DAN94 interfered with mitochondria metabolism promoting reactive oxygen species production, triggering apoptosis and arresting the cancer cells on G1/G0 phase of cell cycle, inhibiting cell proliferation. These effects are not observed when the drug was tested in the non-cancer cell line MCF10A. Using a mouse model with xenograft tumor implants, the drug preventing tumor growth presented no toxicity for the animal and without altering biochemical markers of hepatic function. Results and Conclusion: The novel drug DAN94 is selective for cancer cells, targeting the mitochondrial metabolism, which culminates in the cancer cell death. In the end, DAN94 has been shown to be a promising drug for controlling breast cancer with minimal undesirable effects.

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