Self-assembling peptides cross-linked with genipin: resilient hydrogels and self-standing electrospun scaffolds for tissue engineering applications

2019 ◽  
Vol 7 (1) ◽  
pp. 76-91 ◽  
Author(s):  
Raffaele Pugliese ◽  
Mahboubeh Maleki ◽  
Ronald N. Zuckermann ◽  
Fabrizio Gelain

Molecular cross-linking with genipin enables the production of resilient standard and electro-spun self-standing scaffolds made of self-assembling peptides.

Author(s):  
Elahe Bahremandi-Toloue ◽  
Zahra Mohammadalizadeh ◽  
Shayanti Mukherjee ◽  
Saeed Karbasi

2021 ◽  
Vol 191 ◽  
pp. 500-513
Author(s):  
Maryam Abdollahi Asl ◽  
Saeed Karbasi ◽  
Saeed Beigi-Boroujeni ◽  
Soheila Zamanlui Benisi ◽  
Mahdi Saeed

2004 ◽  
Vol 127 (2) ◽  
pp. 220-228 ◽  
Author(s):  
Jeanie L. Drury ◽  
Tanyarut Boontheekul ◽  
David J. Mooney

Peptide modification of hydrogel-forming materials is being widely explored as a means to regulate the phenotype of cells immobilized within the gels. Alternatively, we hypothesized that the adhesive interactions between cells and peptides coupled to the gel-forming materials would also enhance the overall mechanical properties of the gels. To test this hypothesis, alginate polymers were modified with RGDSP-containing peptides and the resultant polymer was used to encapsulate C2C12 myoblasts. The mechanical properties of these gels were then assessed as a function of both peptide and cell density using compression and tensile tests. Overall, it was found that above a critical peptide and cell density, encapsulated myoblasts were able to provide additional mechanical integrity to hydrogels composed of peptide-modified alginate. This occurred presumably by means of cell-peptide cross-linking of the alginate polymers, in addition to the usual Ca++ cross-linking. These results are potentially applicable to other polymer systems and important for a range of tissue engineering applications.


2008 ◽  
Vol 3 (4) ◽  
pp. 045001 ◽  
Author(s):  
Scott A Sell ◽  
Michael P Francis ◽  
Koyal Garg ◽  
Michael J McClure ◽  
David G Simpson ◽  
...  

2012 ◽  
Vol 88 (4) ◽  
pp. 1239-1250 ◽  
Author(s):  
Silvia Bubenikova ◽  
Izabela-Cristina Stancu ◽  
Lucia Kalinovska ◽  
Etienne Schacht ◽  
Evi Lippens ◽  
...  

2017 ◽  
Vol 37 ◽  
pp. 129-137 ◽  
Author(s):  
Daniel Grande ◽  
Julien Ramier ◽  
Davy Louis Versace ◽  
Estelle Renard ◽  
Valérie Langlois

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