Biomimetic Self-Assembling Peptide Hydrogels for Tissue Engineering Applications

2018 ◽  
pp. 297-312 ◽  
Author(s):  
Jiaju Lu ◽  
Xiumei Wang
Keyword(s):  
Tissue Engineering ◽  
Engineering Applications ◽  
Self Assembling ◽  
Peptide Hydrogels

Synthesis and characterization of designed BMHP1-derived self-assembling peptides for tissue engineering applications

Nanoscale ◽  
2013 ◽  
Vol 5 (2) ◽  
pp. 704-718 ◽  
Author(s):  
Diego Silva ◽  
Antonino Natalello ◽  
Babak Sanii ◽  
Rajesh Vasita ◽  
Gloria Saracino ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Synthesis And Characterization ◽  
Engineering Applications ◽  
Self Assembling

Bimolecular based heparin and self-assembling hydrogel for tissue engineering applications

2015 ◽  
Vol 16 ◽  
pp. 35-48 ◽  
Author(s):  
Teresa Fernández-Muiños ◽  
Lourdes Recha-Sancho ◽  
Patricia López-Chicón ◽  
Cristina Castells-Sala ◽  
Alvaro Mata ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Engineering Applications ◽  
Self Assembling

An Overview of Latest Advances in Exploring Bioactive Peptide Hydrogels for Neural Tissue Engineering

2021 ◽  
Author(s):  
Pooja Sharma ◽  
Vijay Kumar Pal ◽  
Sangita Roy
Keyword(s):  
Tissue Engineering ◽  
Functional Recovery ◽  
Neural Tissue ◽  
Bioactive Peptide ◽  
Neural Tissue Engineering ◽  
Self Assembling ◽  
Medical Therapies ◽  
Peptide Hydrogels

Neural tissue engineering holds great potential in addressing current challenges faced by medical therapies employed for functional recovery of brain. In this context, self-assembling peptides have gained considerable interest owing...

scholarly journals Multicomponent Peptide Hydrogels as an Innovative Platform for Cell-Based Tissue Engineering in the Dental Pulp

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1575
Author(s):  
Marina E. Afami ◽  
Ikhlas El Karim ◽  
Imad About ◽  
Anna D. Krasnodembskaya ◽  
Garry Laverty ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stromal Cells ◽  
Dental Pulp ◽  
Bacterial Infections ◽  
Cultured Cells ◽  
Fusobacterium Nucleatum ◽  
Root Canals ◽  
Self Assembling ◽  
Oral Pathogens ◽  
Peptide Hydrogels

In light of the increasing levels of antibiotic resistance, nanomaterials and novel biologics are urgently required to manage bacterial infections. To date, commercially available self-assembling peptide hydrogels have not been studied extensively for their ability to inhibit micro-organisms relevant to tissue engineering sites such as dental root canals. In this work, we assess the biocompatibility of dental pulp stem/stromal cells with commercially available multicomponent peptide hydrogels. We also determine the effects of dental pulp stem/stromal cell (DPSC) culture in hydrogels on growth factor/cytokine expression. Furthermore, to investigate novel aspects of self-assembling peptide hydrogels, we determine their antimicrobial activity against the oral pathogens Staphylococcus aureus, Enterococcus faecalis, and Fusobacterium nucleatum. We show that self-assembling peptide hydrogels and hydrogels functionalized with the adhesion motif Arg-Gly-Asp (RGD) are biocompatible with DPSCs, and that cells grown in 3D hydrogel cultures produce a discrete secretome compared with 2D-cultured cells. Furthermore, we show that soluble peptides and assembled hydrogels have antimicrobial effects against oral pathogens. Given their antibacterial activity against oral pathogens, biocompatibility with dental pulp stem/stromal cells and enhancement of an angiogenic secretome, multicomponent peptide hydrogels hold promise for translational use.

Self-assembling peptides cross-linked with genipin: resilient hydrogels and self-standing electrospun scaffolds for tissue engineering applications

2019 ◽  
Vol 7 (1) ◽  
pp. 76-91 ◽  
Author(s):  
Raffaele Pugliese ◽  
Mahboubeh Maleki ◽  
Ronald N. Zuckermann ◽  
Fabrizio Gelain
Keyword(s):  
Tissue Engineering ◽  
Cross Linking ◽  
Engineering Applications ◽  
Electrospun Scaffolds ◽  
Self Assembling

Molecular cross-linking with genipin enables the production of resilient standard and electro-spun self-standing scaffolds made of self-assembling peptides.

BMHP1-Derived Self-Assembling Peptides: Hierarchically Assembled Structures with Self-Healing Propensity and Potential for Tissue Engineering Applications

ACS Nano ◽  
2011 ◽  
Vol 5 (3) ◽  
pp. 1845-1859 ◽  
Author(s):  
Fabrizio Gelain ◽  
Diego Silva ◽  
Andrea Caprini ◽  
Francesca Taraballi ◽  
Antonino Natalello ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Self Healing ◽  
Engineering Applications ◽  
Self Assembling

scholarly journals Novel Ultrashort Self-Assembling Peptide Bioinks for 3D Culture of Muscle Myoblast Cells

2018 ◽  
Vol 4 (2) ◽  
Author(s):  
Wafaa Arab ◽  
Sakandar Rauf ◽  
Ohoud Al-Harbi ◽  
Charlotte Hauser
Keyword(s):  
Skeletal Muscle ◽  
Tissue Engineering ◽  
Muscle Tissue ◽  
3D Culture ◽  
Skeletal Muscle Tissue ◽  
C2c12 Cells ◽  
Self Assembling ◽  
3D Network ◽  
Myoblast Cells ◽  
Peptide Hydrogels

The ability of skeletal muscle to self-repair after a traumatic injury, tumor ablation, or muscular disease is slow and limited, and the capacity of skeletal muscle to self-regenerate declines steeply with age. Tissue engineering of functional skeletal muscle using 3D bioprinting technology is promising for creating tissue constructs that repair and promote regeneration of damaged tissue. Hydrogel scaffolds used as biomaterials for skeletal muscle tissue engineering can provide chemical, physical and mechanical cues to the cells in three dimensions thus promoting regeneration. Herein, we have developed two synthetically designed novel tetramer peptide biomaterials. These peptides are self-assembling into a nanofibrous 3D network, entrapping 99.9% water and mimicking the native collagen of an extracellular matrix. Different biocompatibility assays including MTT, 3D cell viability assay, cytotoxicity assay and live-dead assay confirm the biocompatibility of these peptide hydrogels for mouse myoblast cells (C2C12). Immunofluorescence analysis of cell-laden hydrogels revealed that the proliferation of C2C12 cells was well-aligned in the peptide hydrogels compared to the alginate-gelatin control. These results indicate that these peptide hydrogels are suitable for skeletal muscle tissue engineering. Finally, we tested the printability of the peptide bioinks using a commercially available 3D bioprinter. The ability to print these hydrogels will enable future development of 3D bioprinted scaffolds containing skeletal muscle myoblasts for tissue engineering applications.

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