Control over coordination self-assembly of flexible, multidentate ligands by stepwise metal coordination of isopyrazole subunits

2019 ◽  
Vol 48 (3) ◽  
pp. 818-822 ◽  
Author(s):  
Yoshiko Ashida ◽  
Yumehiro Manabe ◽  
Shota Yoshioka ◽  
Tomoki Yoneda ◽  
Yasuhide Inokuma

Structural convergence of the self-assembly of flexible oligoisopyrazoles was controlled by stepwise palladium coordination and discrete complexes with structural diversity were selectively generated in a predictable fashion.

2020 ◽  
Author(s):  
Yuyang Miao ◽  
Shibo Lv ◽  
Daoyuan Zheng ◽  
Yuhan Liu ◽  
Dapeng Liu ◽  
...  

Abstract Porphyrin-based metal coordination polymers (MCPs) have attracted numerous attention due to their great promise application in phototherapy including photodynamic therapy (PDT) and photothermal therapy (PTT). However, the detailed self-assembly process of porphyrin-based MCPs still remains poorly understood. This work provides a detailed study of the self-assembly process of MCPs constructed by Mn2+ and TCPP (TCPP: 4,4′,4′′,4′′′-(Porphine-5,10,15,20-tetrayl)tetrakis(benzoic acid)) in aqueous solution. Unlike traditional nucleation and growth mechanism, we discover that there is a metastable metal-organic intermediate which is kinetically favored in the self-assembly process. And the metastable metal-organic intermediate nanotape structures could convert into thermodynamically favored nanosheets through disassembling into monomers followed by reassembling process. Moreover, the two structurally different assemblies exhibit distinct photophysical performances. The intermediate Mn-TCPP aggregates show good light-induced singlet oxygen 1O2 generation for PDT while the thermodynamic favored stable Mn-TCPP aggregates exhibit good photothermal conversion ability as photothermal agents (PTAs). This study could facilitate controlling self-assembly pathway to fabricate complex MCPs with desirable applications.


2020 ◽  
Vol 49 (39) ◽  
pp. 13685-13692
Author(s):  
Sinan Bayindir ◽  
Kwang Soo Lee ◽  
Nurullah Saracoglu ◽  
Jon R. Parquette

In this work, we report the impact of pH and metal coordination on the self-assembly of amphiphiles comprised of naphthalenediimide (NDI)–bis(indolyl)methane (BIM) chromophores with a charged l-lysine head group.


Polyhedron ◽  
2014 ◽  
Vol 81 ◽  
pp. 273-281 ◽  
Author(s):  
Chun-Wei Yeh ◽  
Chi-Hui Tsou ◽  
Fu-Chang Huang ◽  
Ay Jong ◽  
Maw-Cherng Suen

CrystEngComm ◽  
2011 ◽  
Vol 13 (16) ◽  
pp. 5133 ◽  
Author(s):  
Dawei Yan ◽  
Jie Fu ◽  
Lei Zheng ◽  
Zhibin Zhang ◽  
Yan Xu ◽  
...  

2018 ◽  
Vol 47 (22) ◽  
pp. 7384-7394 ◽  
Author(s):  
Takuya Shiga ◽  
Graham N. Newton ◽  
Hiroki Oshio

This perspective reviews our recent efforts towards the self-assembly of polynuclear clusters with ditopic and tritopic multidentate ligands HL1 (2-phenyl-4,5-bis{6-(3,5-dimethylpyrazol-1-yl)pyrid-2-yl}-1H-imidazole) and H2L2 (2,6-bis-[5-(2-pyridinyl)-1H-pyrazole-3-yl]pyridine), both of which are planar and rigid molecules.


Polyhedron ◽  
2011 ◽  
Vol 30 (13) ◽  
pp. 2260-2267 ◽  
Author(s):  
Chia-Jun Wu ◽  
Chih-Yuan Lin ◽  
Pei-Chi Cheng ◽  
Chun-Wei Yeh ◽  
Jhy-Der Chen ◽  
...  

2021 ◽  
Author(s):  
Yuyang Miao ◽  
Shibo Lv ◽  
Daoyuan Zheng ◽  
Yuhan Liu ◽  
Dapeng Liu ◽  
...  

During the self-assembly process of porphyrin-based metal coordination polymers, two different nanoaggregates were discovered. The nanoaggregates exhibited pathway-dependent properties and showed different applications in phototherapy.


2014 ◽  
Vol 38 (3) ◽  
pp. 1079 ◽  
Author(s):  
Pin-Ning Wang ◽  
Chun-Wei Yeh ◽  
Chi-Hui Tsou ◽  
Yuh-Wen Ho ◽  
Shui-Chuan Lin ◽  
...  

2021 ◽  
Vol 22 (19) ◽  
pp. 10210
Author(s):  
Epole Ntungwe ◽  
Eva María Domínguez-Martín ◽  
Gabrielle Bangay ◽  
Catarina Garcia ◽  
Iris Guerreiro ◽  
...  

Different approaches have been reported to enhance penetration of small drugs through physiological barriers; among them is the self-assembly drug conjugates preparation that shows to be a promising approach to improve activity and penetration, as well as to reduce side effects. In recent years, the use of drug-conjugates, usually obtained by covalent coupling of a drug with biocompatible lipid moieties to form nanoparticles, has gained considerable attention. Natural products isolated from plants have been a successful source of potential drug leads with unique structural diversity. In the present work three molecules derived from natural products were employed as lead molecules for the synthesis of self-assembled nanoparticles. The first molecule is the cytotoxic royleanone 7α-acetoxy-6β-hydroxyroyleanone (Roy, 1) that has been isolated from hairy coleus (Plectranthus hadiensis (Forssk.) Schweinf). ex Sprenger leaves in a large amount. This royleanone, its hemisynthetic derivative 7α-acetoxy-6β-hydroxy-12-benzoyloxyroyleanone (12BzRoy, 2) and 6,7-dehydroroyleanone (DHR, 3), isolated from the essential oil of thicket coleus (P. madagascariensis (Pers.) Benth.) were employed in this study. The royleanones were conjugated with squalene (sq), oleic acid (OA), and/or 1-bromododecane (BD) self-assembly inducers. Roy-OA, DHR-sq, and 12BzRoy-sq conjugates were successfully synthesized and characterized. The cytotoxic effect of DHR-sq was previously assessed on three human cell lines: NCI-H460 (IC50 74.0 ± 2.2 µM), NCI-H460/R (IC50 147.3 ± 3.7 µM), and MRC-5 (IC50 127.3 ± 7.3 µM), and in this work Roy-OA NPs was assayed against Vero-E6 cells at different concentrations (0.05, 0.1, and 0.2 mg/mL). The cytotoxicity of DHR-sq NPs was lower when compared with DHR alone in these cell lines: NCI-H460 (IC50 10.3 ± 0.5 µM), NCI-H460/R (IC50 10.6 ± 0.4 µM), and MRC-5 (IC5016.9 ± 0.5 µM). The same results were observed with Roy-OA NPs against Vero-E6 cells as was found to be less cytotoxic than Roy alone in all the concentrations tested. From the obtained DLS results, 12BzRoy-sq assemblies were not in the nano range, although Roy-OA NP assemblies show a promising size (509.33 nm), Pdl (0.249), zeta potential (−46.2 mV), and spherical morphology from SEM. In addition, these NPs had a low release of Roy at physiological pH 7.4 after 24 h. These results suggest the nano assemblies can act as prodrugs for the release of cytotoxic lead molecules.


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