scholarly journals Non-coordinative metal selectivity bias in human metallothioneins metal–thiolate clusters

Metallomics ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1777-1791 ◽  
Author(s):  
Jenifer S. Calvo ◽  
Victor M. Lopez ◽  
Gabriele Meloni
Keyword(s):  
Selectivity Bias ◽  
Metal Selectivity ◽  
Mammalian Metallothioneins

Mammalian metallothioneins MT-2 and MT-3 contain two metal–thiolate clusters through cysteine coordination of d10 metals, Cu(i) and Zn(ii), and isoform-specific non-coordinating residues control their respective zinc– and copper–thionein character.

Metal Selectivity of Exocytosis in α-Toxin-Permeabilized Bovine Chromaffin Cells

2002 ◽  
Vol 66 (2) ◽  
pp. 644-650 ◽  
Author(s):  
J. L. Tomsig ◽  
J. B. Suszkiw
Keyword(s):  
Chromaffin Cells ◽  
Metal Selectivity ◽  
Bovine Chromaffin Cells

scholarly journals Cytosolic Ni(II) Sensor in Cyanobacterium

2012 ◽  
Vol 287 (15) ◽  
pp. 12142-12151 ◽  
Author(s):  
Andrew W. Foster ◽  
Carl J. Patterson ◽  
Rafael Pernil ◽  
Corinna R. Hess ◽  
Nigel J. Robinson
Keyword(s):  
Coordination Sphere ◽  
Promoter Region ◽  
Nitrilotriacetic Acid ◽  
The Other ◽  
Cryptic Promoter ◽  
Difference Spectra ◽  
Inner Membrane ◽  
Fura 2 ◽  
Metal Selectivity ◽  
Metal Sensors

Efflux of surplus Ni(II) across the outer and inner membranes of Synechocystis PCC 6803 is mediated by the Nrs system under the control of a sensor of periplasmic Ni(II), NrsS. Here, we show that the product of ORF sll0176, which encodes a CsoR/RcnR-like protein now designated InrS (for internal nickel-responsive sensor), represses nrsD (NrsD is deduced to efflux Ni(II) across the inner membrane) from a cryptic promoter between the final two ORFs in the nrs operon. Transcripts initiated from the newly identified nrsD promoter accumulate in response to nickel or cobalt but not copper, and recombinant InrS forms specific, Ni(II)-inhibited complexes with the nrsD promoter region. Metal-dependent difference spectra of Ni(II)- and Cu(I)-InrS are similar to Cu(I)-sensing CsoR and dissimilar to Ni(II)/Co(II)-sensing RcnR, consistent with factors beyond the primary coordination sphere switching metal selectivity. Competition with chelators mag-fura-2, nitrilotriacetic acid, EDTA, and EGTA estimate KD Ni(II) for the tightest site of InrS as 2.05 (±1.5) × 10−14m, and weaker KD Ni(II) for the cells' metal sensors of other types: Zn(II) co-repressor Zur, Co(II) activator CoaR, and Zn(II) derepressor ZiaR. Ni(II) transfer to InrS occurs upon addition to Ni(II) forms of each other sensor. InrS binds Ni(II) sufficiently tightly to derepress Ni(II) export at concentrations below KD Ni(II) of the other sensors.

Agricultural cooperative membership and technical efficiency of apple farmers in China: An analysis accounting for selectivity bias

Food Policy ◽  
2018 ◽  
Vol 81 ◽  
pp. 122-132 ◽  
Author(s):  
Wanglin Ma ◽  
Alan Renwick ◽  
Peng Yuan ◽  
Nazmun Ratna
Keyword(s):  
Technical Efficiency ◽  
Selectivity Bias ◽  
Agricultural Cooperative

Mammalian metallothioneins: properties and functions

Metallomics ◽  
2012 ◽  
Vol 4 (8) ◽  
pp. 739 ◽  
Author(s):  
Petr Babula ◽  
Michal Masarik ◽  
Vojtech Adam ◽  
Tomas Eckschlager ◽  
Marie Stiborova ◽  
...  
Keyword(s):  
Mammalian Metallothioneins

scholarly journals Ultrasensitivity and heavy-metal selectivity of the allosterically modulated MerR transcription complex.

1990 ◽  
Vol 87 (10) ◽  
pp. 3846-3850 ◽  
Author(s):  
D. M. Ralston ◽  
T. V. O'Halloran
Keyword(s):  
Heavy Metal ◽  
Metal Selectivity

scholarly journals Evolution of Metal Selectivity in Templated Protein Interfaces

2010 ◽  
Vol 132 (25) ◽  
pp. 8610-8617 ◽  
Author(s):  
Jeffrey D. Brodin ◽  
Annette Medina-Morales ◽  
Thomas Ni ◽  
Eric N. Salgado ◽  
Xavier I. Ambroggio ◽  
...  
Keyword(s):  
Protein Interfaces ◽  
Metal Selectivity

ChemInform Abstract: Enantioselective Electrophilic Trifluoromethylthiolation of β-Ketoesters: A Case of Reactivity and Selectivity Bias for Organocatalysis.

ChemInform ◽  
2014 ◽  
Vol 45 (19) ◽  
pp. no-no
Author(s):  
Xueqiang Wang ◽  
Tao Yang ◽  
Xiaolin Cheng ◽  
Qilong Shen
Keyword(s):  
Selectivity Bias
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