Luminescent gold nanoclusters for in vivo tumor imaging

Luminescent nanomaterials have emerged as attractive candidates for sensing, catalysis and bioimaging applications in recent years. For practical use in bioimaging, nanomaterials with high photoluminescence, quantum yield, photostability and large Stokes shifts are needed. While offering high photoluminescence and quantum yield, semiconductor quantum dots suffer from toxicity and are susceptible to oxidation. In this context, atomically precise gold nanoclusters protected by thiol monolayers have emerged as a new class of luminescent nanomaterials. Low toxicity, bioavailability, photostability as well as tunable size, composition, and optoelectronic properties make them suitable for bioimaging and biosensing applications. In this review, an overview of the sensing of pathogens, and of in vitro and in vivo bioimaging using luminescent gold nanoclusters along with the limitations with selected examples are discussed.

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Elemental and optical imaging evaluation of zwitterionic gold nanoclusters in glioblastoma mouse models

Nanoscale ◽

10.1039/c8nr05299a ◽

2018 ◽

Vol 10 (39) ◽

pp. 18657-18664 ◽

Cited By ~ 17

Author(s):

Xavier Le Guével ◽

Maxime Henry ◽

Vincent Motto-Ros ◽

Elena Longo ◽

Maria I. Montañez ◽

...

Keyword(s):

Optical Imaging ◽

Mouse Models ◽

Gold Nanoclusters ◽

Imaging Evaluation ◽

Luminescent Gold Nanoclusters

We report the in vivo biodistribution of luminescent gold nanoclusters (NCs) stabilized by bidentate zwitterionic molecules in subcutaneous and orthotopic glioblastoma mice models.

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Biosynthesis of fluorescent gold nanoclusters for in vitro and in vivo tumor imaging

Optics Communications ◽

10.1016/j.optcom.2015.07.023 ◽

2015 ◽

Vol 355 ◽

pp. 567-574 ◽

Cited By ~ 13

Author(s):

Linlin Li ◽

Xi Liu ◽

Changhui Fu ◽

Longfei Tan ◽

Huiyu Liu

Keyword(s):

Tumor Imaging ◽

Gold Nanoclusters

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Fluorescent Gold Nanoclusters for Biosensor and Bioimaging Application

Crystals ◽

10.3390/cryst10050357 ◽

2020 ◽

Vol 10 (5) ◽

pp. 357 ◽

Cited By ~ 3

Author(s):

Yunlong Bai ◽

Tong Shu ◽

Lei Su ◽

Xueji Zhang

Keyword(s):

Tumor Imaging ◽

Rapid Development ◽

Gold Nanoclusters ◽

Chemical Properties ◽

Functional Materials ◽

Synthetic Methods ◽

Design Strategies ◽

Detection Of Biomarkers

With the rapid development of materials technology, fluorescent gold nanoclusters (AuNCs) are emerging as novel functional materials for diagnostic applications including the detection of biomarkers and bioimaging due to the advantages of their ultra-small size, tunable emissions, size-dependent fluorescence and excellent biocompatibility. In this review, we introduced the synthetic methods, and physical and chemical properties of AuNCs. Subsequently, we described the AuNCs-based design strategies for the detection of biomarkers including small molecules, DNA and proteins. The applications of AuNCs for tumor imaging in vitro and in vivo were also presented. Finally, we discussed the challenges and potential solutions of AuNCs-based nanosensors.

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Patients with fever of unknown origin (FUO): diagnosis by nuclear medicine imaging

Nuklearmedizin ◽

10.1055/s-0038-1623872 ◽

2001 ◽

Vol 40 (03) ◽

pp. 59-70 ◽

Cited By ~ 13

Author(s):

W. Becker ◽

J. Meiler

Keyword(s):

Nuclear Medicine ◽

Fever Of Unknown Origin ◽

Tumor Imaging ◽

White Blood Cells ◽

Unknown Origin ◽

Final Diagnosis ◽

Recurrent Fever ◽

Nuclear Medicine Imaging

SummaryFever of unknown origin (FUO) in immunocompetent and non neutropenic patients is defined as recurrent fever of 38,3° C or greater, lasting 2-3 weeks or longer, and undiagnosed after 1 week of appropriate evaluation. The underlying diseases of FUO are numerous and infection accounts for only 20-40% of them. The majority of FUO-patients have autoimmunity and collagen vascular disease and neoplasm, which are responsible for about 50-60% of all cases. In this respect FOU in its classical definition is clearly separated from postoperative and neutropenic fever where inflammation and infection are more common. Although methods that use in-vitro or in-vivo labeled white blood cells (WBCs) have a high diagnostic accuracy in the detection and exclusion of granulocytic pathology, they are only of limited value in FUO-patients in establishing the final diagnosis due to the low prevalence of purulent processes in this collective. WBCs are more suited in evaluation of the focus in occult sepsis. Ga-67 citrate is the only commercially available gamma emitter which images acute, chronic, granulomatous and autoimmune inflammation and also various malignant diseases. Therefore Ga-67 citrate is currently considered to be the tracer of choice in the diagnostic work-up of FUO. The number of Ga-67-scans contributing to the final diagnosis was found to be higher outside Germany than it has been reported for labeled WBCs. F-l 8-2’-deoxy-2-fluoro-D-glucose (FDG) has been used extensively for tumor imaging with PET. Inflammatory processes accumulate the tracer by similar mechanisms. First results of FDG imaging demonstrated, that FDG may be superior to other nuclear medicine imaging modalities which may be explained by the preferable tracer kinetics of the small F-l 8-FDG molecule and by a better spatial resolution of coincidence imaging in comparison to a conventional gamma camera.

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Click Chemistry Expedited Radiosynthesis: Sulfur [18F]fluoride Exchange of Aryl Fluorosulfates

10.26434/chemrxiv.10314647.v1 ◽

2019 ◽

Cited By ~ 1

Author(s):

Qinheng Zheng ◽

Hongtao Xu ◽

Hua Wang ◽

Wen-Ge Han Du ◽

Nan Wang ◽

...

Keyword(s):

Click Chemistry ◽

High Performance ◽

Isotopic Exchange ◽

Tumor Imaging ◽

Radiochemical Yield ◽

Exchange Method ◽

Molar Activity ◽

Positron Emission ◽

Sulfur Fluoride

The lack of simple, efficient [18F]fluorination processes and new target-specific organofluorine probes remains the major challenge of fluorine-18-based positron emission tomography (PET). We report here a fast isotopic exchange method for the radiosynthesis of aryl [18F]fluorosulfate based PET agents enabled by the emerging sulfur fluoride exchange (SuFEx) click chemistry. The method has been applied to the fully-automated 18F-radiolabeling of twenty-five structurally diverse aryl fluorosulfates with excellent radiochemical yield (83–100%) and high molar activity (up to 281 GBq µmol–1) at room temperature in 30 seconds. The purification of radiotracers requires no time-consuming high-performance liquid chromatography (HPLC), but rather a simple cartridge filtration. The utility of aryl [18F]fluorosulfate is demonstrated by the in vivo tumor imaging by targeting poly(ADP-ribose) polymerase 1 (PARP1).

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Cyanine Fluorochrome-Labeled Antibodies in Vivo: Assessment of Tumor Imaging Using Cy3, Cy5, Cy5.5, and Cy7

Cancer Detection and Prevention ◽

10.1046/j.1525-1500.1998.0oa25.x ◽

1998 ◽

Vol 22 (3) ◽

pp. 251-257 ◽

Cited By ~ 37

Author(s):

Byron Ballou ◽

Gregory W. Fisher ◽

Jau-Shyong Deng ◽

Thomas R. Hakala ◽

Meera Srivastava ◽

...

Keyword(s):

Tumor Imaging ◽

In Vivo Assessment

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Protein-templated gold nanoclusters as specific bio-imaging probes for the detection of Hg(ii) ions in in vivo and in vitro systems: discriminating between MDA-MB-231 and MCF10A cells

The Analyst ◽

10.1039/d0an02108c ◽

2021 ◽

Author(s):

Subhajit Chakraborty ◽

Atanu Nandy ◽

Subhadip Ghosh ◽

Nirmal Kumar Das ◽

Sameena Parveen ◽

...

Keyword(s):

Breast Cancer ◽

Human Serum Albumin ◽

Gold Nanoclusters ◽

Selective Detection ◽

Imaging Probes ◽

Bio Imaging ◽

In Vitro Systems ◽

Mcf10a Cells

Sub-nanomolar selective detection of Hg(ii) ions by protein (Human Serum Albumin, HSA) templated gold nanoclusters (AuNCs), both in in vitro as well as in vivo environments and specific endocytose behaviour towards breast cancer (BC) cell lines.

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Dual-Stimulus Responsive Near-Infrared Reversible Ratiometric Fluorescent and Photoacoustic Probe for In Vivo Tumor Imaging

Analytical Chemistry ◽

10.1021/acs.analchem.0c04804 ◽

2021 ◽

Author(s):

Xiao Liu ◽

Xiangyang Gong ◽

Jie Yuan ◽

Xiaopeng Fan ◽

Xingxing Zhang ◽

...

Keyword(s):

Near Infrared ◽

Tumor Imaging ◽

Stimulus Responsive

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