scholarly journals Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties

2019 ◽  
Vol 55 (57) ◽  
pp. 8227-8230 ◽  
Author(s):  
Ana I. Carbajo-Gordillo ◽  
Julio Rodríguez-Lavado ◽  
José Luis Jiménez Blanco ◽  
Juan M. Benito ◽  
Christophe Di Giorgio ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Core Shell ◽  
Self Assembling ◽  
Selective Delivery ◽  
Siamese Twin

Trehalose Siamese twin vectors, encompassing gemini and facial amphiphilicity, promote pDNA compaction into core–shell nanocomplexes and selective delivery in the lungs.

Development of self-assembling peptide nanovesicle with bilayers for enhanced EGFR-targeted drug and gene delivery

Biomaterials ◽  
2016 ◽  
Vol 82 ◽  
pp. 194-207 ◽  
Author(s):  
Xiaofei Liang ◽  
Bizhi Shi ◽  
Kai Wang ◽  
Mingliang Fan ◽  
Dejin Jiao ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Self Assembling ◽  
Targeted Drug ◽  
Drug And Gene Delivery

scholarly journals Efficient gene delivery using a novel core‐shell nanoparticle and HMGB1 system

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Yuen Shan Siu ◽  
Min Feng ◽  
Xiao Peng ◽  
Pei Li ◽  
Kam Len Daniel Lee
Keyword(s):  
Gene Delivery ◽  
Core Shell ◽  
Efficient Gene

scholarly journals Cyclodextrin-scaffolded amphiphilic aminoglucoside clusters: self-assembling and gene delivery capabilities

2014 ◽  
Vol 38 (11) ◽  
pp. 5215-5225 ◽  
Author(s):  
Eva M. Aguilar Moncayo ◽  
Nicolas Guilloteau ◽  
Céline Bienvenu ◽  
José L. Jiménez Blanco ◽  
Christophe Di Giorgio ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Gene Delivery ◽  
The Self ◽  
Self Assembling

The self-assembling and gene transfer capabilities of monodisperse amphiphilic aminoglucoside–cyclodextrin conjugates depend on the amino disposition at the glycationic head.

Receptor-Mediated Gene Delivery Using Chitosan Derivatives In Vitro and In Vivo

2007 ◽  
Vol 342-343 ◽  
pp. 449-452 ◽  
Author(s):  
Tae Hee Kim ◽  
Hua Jin ◽  
Hyun Woo Kim ◽  
Myung Haing Cho ◽  
Jae Woon Nah ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Transfection Efficiency ◽  
Viral Gene ◽  
Gene Delivery System ◽  
Targeted Gene Delivery ◽  
Cell Specificity ◽  
Selective Delivery

The key strategy for the advancement of gene therapy is the development of an efficient targeted gene delivery system into cells. The targeted gene delivery system is especially important in non-viral gene transfer which shows the relatively low transfection efficiency. It also opens the possibility of selective delivery of therapeutic plasmids to specific tissues. Chitosan has been considered to be a good candidate for gene delivery system, since it is already known as a biocompatible, biodegradable, and low toxic material with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this study, we focused on the chemical modification of chitosan for enhancement of cell specificity and transfection efficiency. Also, the potential of clinical application was investigated.

Photodegradable self-assembling PAMAM dendrons for gene delivery involving dendriplex formation and phototriggered circular DNA release

2016 ◽  
Vol 40 (3) ◽  
pp. 2601-2608 ◽  
Author(s):  
Yu-Sen Lai ◽  
Chai-Lin Kao ◽  
Ya-Pei Chen ◽  
Chia-Chia Fang ◽  
Chao-Chin Hu ◽  
...  
Keyword(s):  
Dna Binding ◽  
Gene Delivery ◽  
Self Assembly ◽  
Circular Dna ◽  
Self Assembling ◽  
Dna Release

Photoresponsive amphiphilic dendron bearing a photolabile o-nitrobenzyl group possesses self-assembly, DNA binding and photo-induced release.

Multifunctional “core-shell” nanoparticles-based gene delivery for treatment of aggressive melanoma

Biomaterials ◽  
2016 ◽  
Vol 111 ◽  
pp. 124-137 ◽  
Author(s):  
Ling Li ◽  
Linjiang Song ◽  
Xi Yang ◽  
Xia Li ◽  
Yuzhe Wu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

Fabrication and Characterization of Spectroscopically Encoded Core-shell Nanoparticle-polymer Nanocomposite

2007 ◽  
Vol 1054 ◽  
Author(s):  
Sheng Dai ◽  
Abdiaziz A. Farah ◽  
Ramon A Alvarez-Puebla ◽  
Juan P Bravo-Vasquez ◽  
Hicham Fenniri
Keyword(s):  
Metal Nanoparticles ◽  
Noble Metals ◽  
Water Soluble ◽  
Metallic Surface ◽  
Core Shell ◽  
Seeded Emulsion Polymerization ◽  
Binding Interaction ◽  
Self Assembling ◽  
Vis Spectroscopy ◽  
Sulfur Containing

ABSTRACTMetal nanoparticles are of great importance in the fabrication of new nanocomposite materials. One area of increasing interest is the application of metal nanoparticles (NP) as substrates for surface enhanced Raman scattering (SERS). In this regard, self-assembled monolayers (SAMs) of sulfur containing organic compounds are ideal target for SERS studies due to the strong affinity of sulfur for noble metals. Two types of molecules were synthesized for this study, an organic-soluble and a water-soluble styrene derivative. Self-assembling behaviors of these monomers on gold or silver nanostructured surfaces at room temperature were studied by UV-Vis spectroscopy, dynamic light scattering (DLS), SERS spectroscopy, and scanning electron microscopy (SEM). It was found that the interaction between sulfur compounds and metal NPs is strongly dependent on the NP size and the monomer environment. The hydrophilic NP surface switches to hydrophobic upon binding of sulfur-containing monomers, which leads to the formation of aggregates in aqueous solution for both water-soluble and oil-soluble monomers. The self-assembling behavior of these monomers on the metallic surface was compared with that of the corresponding homopolymers. Due to macromolecular and steric effects, the binding interaction between homopolymer and metal NP is weaker than that between NP and monomers. Surface polymerization of these monomers on metallic surfaces was observed as supported by SERS. Core-shell nanoparticles could also be obtained through seeded emulsion polymerization, but a decrease in SERS activity was observed.

Protonation of Graphitic Carbon Nitride (g-C3N4) for an Electrostatically Self-Assembling Carbon@g-C3N4 Core–Shell Nanostructure toward High Hydrogen Evolution

2017 ◽  
Vol 5 (8) ◽  
pp. 7093-7103 ◽  
Author(s):  
Longtao Ma ◽  
Huiqing Fan ◽  
Ke Fu ◽  
Shenhui Lei ◽  
Qingzhao Hu ◽  
...  
Keyword(s):  
Hydrogen Evolution ◽  
Carbon Nitride ◽  
Graphitic Carbon ◽  
Graphitic Carbon Nitride ◽  
Core Shell ◽  
High Hydrogen ◽  
Self Assembling

scholarly journals Splenic Gene Delivery System Using Self-assembling Nano-complex with Phosphatidylserine Analog

2015 ◽  
Vol 38 (1) ◽  
pp. 23-29 ◽  
Author(s):  
Tomoaki Kurosaki ◽  
Chihiro Nakasone ◽  
Yukinobu Kodama ◽  
Kanoko Egashira ◽  
Hitomi Harasawa ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Gene Delivery System ◽  
Self Assembling
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