scholarly journals Nanoparticle translocation across the lung surfactant film regulated by grafting polymers

Nanoscale ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 3931-3940 ◽  
Author(s):  
Xuan Bai ◽  
Mujun Li ◽  
Guoqing Hu
Keyword(s):  
Lung Surfactant ◽  
Grafting Density ◽  
Surfactant Film

Conditioning of grafting polymers, including their length, terminal charge, and grafting density, can result in different translocation processes of nanoparticles across the lung surfactant film.

Molecular modeling of nanoplastic transformations in alveolar fluid and impacts on the lung surfactant film

2021 ◽  
pp. 127872
Author(s):  
Lingzhi Li ◽  
Yan Xu ◽  
Shixin Li ◽  
Xiaoyang Zhang ◽  
Hao Feng ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Lung Surfactant ◽  
Surfactant Film

Size Dependent Interactions of Nanoparticles with Lung Surfactant Model Systems and the Significant Impact on Surface Potential

2008 ◽  
Vol 8 (6) ◽  
pp. 2971-2978 ◽  
Author(s):  
Tabitha Ku ◽  
Simardeep Gill ◽  
Raimar Löbenberg ◽  
Shirzad Azarmi ◽  
Wilson Roa ◽  
...  
Keyword(s):  
Surface Potential ◽  
Surface Pressure ◽  
High Surface ◽  
Lung Surfactant ◽  
Drug Carriers ◽  
Model Systems ◽  
Optimal Size ◽  
Surfactant Film ◽  
Pressure Area ◽  
The Relationship

The relationship between a model pulmonary surfactant system and various sized nanoparticles was investigated in this study. Diplamitoylphosphatidylcholine (DPPC) is the main lipid constituent of lung surfactant and has the ability to reach very high surface pressures (around 70 mN/m) upon compression. Due to these properties it was used as a model to simulate the lung surfactant film in vitro. The first objective of this study was to investigate the relationship between DPPC and various sized nanoparticles within the subphase through surface pressure—area isotherms. The second objective was to measure the surface potential of the different preparations (conducted on a mini-Langmuir trough) and to determine if an optimal nanoparticle size exists possessing a greater affinity for the DPPC film compared to other sizes. The results from the pressure area isotherms indicate that the interaction between DPPC and the nanoparticles is stable and that the 235 nm particles may represent an optimal size. Furthermore, the results from the surface potential experiments confirm that an interaction of the nanoparticles with the monolayer exists as indicated by surface-pressure area isotherms. Any even moderate interaction between nanoparticles and lung surfactant film might reduce or increase the surface potential of the surfactant film, and this might impact the deposition of the nanoparticles or other ligands which may be positively or negatively charged drugs within the surfactant film. Thus changes in surface potential due to nanoparticle interactions have to be taken into account for future drug targeting studies using nano-sized drug carriers.

scholarly journals Increasing Hydrophobicity of Nanoparticles Intensifies Lung Surfactant Film Inhibition and Particle Retention

2014 ◽  
Vol 2 (7) ◽  
pp. 1574-1580 ◽  
Author(s):  
Russell P. Valle ◽  
Charlotte Liwen Huang ◽  
Joachim S. C. Loo ◽  
Yi Y. Zuo
Keyword(s):  
Lung Surfactant ◽  
Surfactant Film ◽  
Particle Retention

Dynamic Behavior of Lung Surfactant

2000 ◽  
Vol 123 (1) ◽  
pp. 106-113 ◽  
Author(s):  
J. Morris ◽  
E. P. Ingenito ◽  
L. Mark ◽  
R. D. Kamm ◽  
M. Johnson
Keyword(s):  
Steady State ◽  
Lung Surfactant ◽  
Diffusion Constant ◽  
Significant Elevation ◽  
Diffusion Limited ◽  
Surfactant Film ◽  
Transient Period ◽  
Film Collapse ◽  
Air Liquid Interface ◽  
And Diffusion

We have previously developed an adsorption-limited model to describe the exchange of lung surfactant and its fractions to and from an air–liquid interface in oscillatory surfactometers. Here we extend this model to allow for diffusion in the liquid phase. Use of the model in conjunction with experimental data in the literature shows that diffusion-limited transport is important for characterizing the transient period from the start of oscillations to the achievement of steady-state conditions. Matching previous data shows that upon high levels of film compression, large changes occur in adsorption rate, desorption rate, and diffusion constant, consistent with what one might expect if the subsurface region was greatly enriched in DPPC. Collapse of the surfactant film that occurs during compression leads to a significant elevation of surfactant concentration immediately beneath the interface, consistent with the subsurface depot of surfactant that has been postulated by other investigators. Modeling studies also uncovered a phenomenon of surfactant behavior in which the interfacial tension remains constant at its minimum equilibrium value while the film is compressed, but without collapse of the film. The phenomenon was due to desorption of surfactant from the interface and termed “pseudo-film collapse.” The new model also gave improved agreement with steady-state oscillatory cycling in a pulsating bubble surfactometer.

scholarly journals Environmental tobacco smoke effects on lung surfactant film organization

2009 ◽  
Vol 1788 (2) ◽  
pp. 358-370 ◽  
Author(s):  
Patrick C. Stenger ◽  
Coralie Alonso ◽  
Joseph A. Zasadzinski ◽  
Alan J. Waring ◽  
Chun-Ling Jung ◽  
...  
Keyword(s):  
Environmental Tobacco Smoke ◽  
Tobacco Smoke ◽  
Lung Surfactant ◽  
Surfactant Film

In vivo effects of TGF-β1 in lung surfactant regulation, lung meachanics amd structure

Pneumologie ◽  
2014 ◽  
Vol 68 (06) ◽  
Author(s):  
E Lopez-Rodriguez ◽  
C Boden ◽  
S Knippenberg ◽  
A Pascual ◽  
J Perez-Gil ◽  
...  
Keyword(s):  
Lung Surfactant ◽  
In Vivo Effects ◽  
Tgf Β1

High-resolution Studies of Lung Surfactant Collapse¶

2004 ◽  
Vol 80 (3) ◽  
pp. 471 ◽  
Author(s):  
Rachel Sibug-Aga ◽  
Robert C. Dunn
Keyword(s):  
High Resolution ◽  
Lung Surfactant
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