The mechanism and structure–activity relationship of amide bond formation by silane derivatives: a computational study

2019 ◽  
Vol 17 (41) ◽  
pp. 9232-9242 ◽  
Author(s):  
Ben Hu ◽  
Yuan-Ye Jiang ◽  
Peng Liu ◽  
Rui-Xue Zhang ◽  
Qi Zhang ◽  
...  
Keyword(s):  
Reaction Mechanism ◽  
Computational Study ◽  
Bond Formation ◽  
Structure Activity Relationship ◽  
Amide Bond ◽  
Activity Relationship ◽  
Amide Bond Formation ◽  
Structure Activity ◽  
Detailed Reaction Mechanism ◽  
Relationship Of

The detailed reaction mechanism and structure–activity relationship of substrates in silane reagent-mediated amide bond formation reactions are clarified.

A computational study on the mechanism of ynamide-mediated amide bond formation from carboxylic acids and amines

2017 ◽  
Vol 15 (30) ◽  
pp. 6367-6374 ◽  
Author(s):  
Song-Lin Zhang ◽  
Hai-Xing Wan ◽  
Zhu-Qin Deng
Keyword(s):  
Reaction Mechanism ◽  
Carboxylic Acids ◽  
Computational Study ◽  
Bond Formation ◽  
Amide Bond ◽  
Reactivity Pattern ◽  
Amide Bond Formation ◽  
Coupling Reagent ◽  
Catalytic Effects ◽  
Acid Substrate

A detailed computational study is presented on the reaction mechanism of ynamide-mediated condensation of carboxylic acids with amines to produce amides, which elucidates the reactivity pattern of the coupling reagent ynamide and discloses crucial bifunctional catalytic effects of the carboxylic acid substrate during aminolysis.

Environmentally-benign catalysts for the selective catalytic reduction of NOxfrom diesel engines: structure–activity relationship and reaction mechanism aspects

2014 ◽  
Vol 50 (62) ◽  
pp. 8445-8463 ◽  
Author(s):  
Fudong Liu ◽  
Yunbo Yu ◽  
Hong He
Keyword(s):  
Reaction Mechanism ◽  
Selective Catalytic Reduction ◽  
Diesel Engines ◽  
Catalytic Reduction ◽  
Structure Activity Relationship ◽  
Environmentally Benign ◽  
Activity Relationship ◽  
Structure Activity ◽  
Scr Catalysts ◽  
Relationship Of

The structure–activity relationship of vanadium-free NH3-SCR catalysts and the HC-SCR reaction mechanism over the Ag/Al2O3catalyst are comprehensively summarized.

Structure-activity relationship of (-) mammea A/BB derivatives against Leishmania amazonensis

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
MA Brenzan ◽  
CV Nakamura ◽  
BPD Filho ◽  
T Ueda-Nakamura ◽  
MCM Young ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Leishmania Amazonensis ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of

Structure Activity Relationship of Kahalalide F and its Analogs Against Fusarium Spp

Planta Medica ◽  
2008 ◽  
Vol 74 (03) ◽  
Author(s):  
N Kasanah ◽  
AG Shilabin ◽  
DE Wedge ◽  
MT Hamann
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Fusarium Spp ◽  
Structure Activity ◽  
Kahalalide F ◽  
Relationship Of

Antineoplastic Activity, Structural Modification, Synthesis and Structure-activity Relationship of Dammarane-type Ginsenosides: An Overview

2019 ◽  
Vol 23 (5) ◽  
pp. 503-516 ◽  
Author(s):  
Qiang Zhang ◽  
Xude Wang ◽  
Liyan Lv ◽  
Guangyue Su ◽  
Yuqing Zhao
Keyword(s):  
Structural Modification ◽  
Gastrointestinal Disease ◽  
Structure Activity Relationship ◽  
Cerebrovascular Diseases ◽  
Activity Relationship ◽  
Cycle Arrest ◽  
Structure Activity ◽  
Wide Range ◽  
Structural Association ◽  
Relationship Of

Dammarane-type ginsenosides are a class of tetracyclic triterpenoids with the same dammarane skeleton. These compounds have a wide range of pharmaceutical applications for neoplasms, diabetes mellitus and other metabolic syndromes, hyperlipidemia, cardiovascular and cerebrovascular diseases, aging, neurodegenerative disease, bone disease, liver disease, kidney disease, gastrointestinal disease and other conditions. In order to develop new antineoplastic drugs, it is necessary to improve the bioactivity, solubility and bioavailability, and illuminate the mechanism of action of these compounds. A large number of ginsenosides and their derivatives have been separated from certain herbs or synthesized, and tested in various experiments, such as anti-proliferation, induction of apoptosis, cell cycle arrest and cancer-involved signaling pathways. In this review, we have summarized the progress in structural modification, shed light on the structure-activity relationship (SAR), and offered insights into biosynthesis-structural association. This review is expected to provide a preliminary guide for the modification and synthesis of ginsenosides.

Design, Facile Synthesis, Antibacterial Activity and Structure-Activity Relationship of Novel Di- and Tri-Substituted 1,3,5-Triazines

2012 ◽  
Vol 9 (3) ◽  
pp. 329-335 ◽  
Author(s):  
Surajit Kumar Ghosh ◽  
Ashmita Saha ◽  
Bornali Hazarika ◽  
Udaya Pratap Singh ◽  
Hans Raj Bhat ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Facile Synthesis ◽  
Structure Activity ◽  
Relationship Of
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