scholarly journals New transition metal complexes with a pendent indole ring: insights into the antifungal activity and mode of action

RSC Advances ◽  
2019 ◽  
Vol 9 (27) ◽  
pp. 15151-15157 ◽  
Author(s):  
Ovas Ahmad Dar ◽  
Shabir Ahmad Lone ◽  
Manzoor Ahmad Malik ◽  
Mohmmad Younus Wani ◽  
Aijaz Ahmad ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Proton Pump ◽  
Mode Of Action ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Indole Ring ◽  
Significant Proton

Mixed ligand complexes containing a pendent indole showed significant proton pump ATPase targeted antifungal activity.

scholarly journals Studies on Antibacterial and Antifungal Activities and Minimum Inhibitory Concentrations of Mixed Ligand Transition Metal Complexes of Dibasic Acids as Primary and Heterocyclic Bases as Secondary Ligands

1970 ◽  
Vol 46 (3) ◽  
pp. 365-368 ◽  
Author(s):  
MA Akbor ◽  
MS Islam ◽  
N Akhter ◽  
S Ahmed ◽  
S Siraj
Keyword(s):  
Antifungal Activity ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Mixed Ligand ◽  
Diffusion Method ◽  
Antifungal Activities ◽  
Minimum Inhibitory Concentrations ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

Mixed ligand (diphenic/ adipic as primary Ligand and quinoline / 8 - hydroxyquinoline as secondary) transition metal complexes of Cobalt (II), Cupper (II), Rhodium (III) and Platinum (IV) ions were synthesized and characterized. Their antibacterial activities against ten bacteria had been evaluated by the disc diffusion method,whilst their antifungal activities against two fungi had been also evaluated by the same method. Minimum inhibitory concentrations (MIC) had been evaluated against six bacteria. The MIC of the complexes against Shigella dysenteriae, Samonella typhi, Streptococcus-β-haemolyticus and Bacillus megaterium were 32 μg/ml; whilst Escherichia coli and Samonella typhi-A the MIC of Co (II) and Pt (IV) were 32μg/ml and those of Cu(II) and Rh(III) complexes were 64 μg/ml. It was found that Cobalt (II), Cupper (II) & Rhodium (III) complexes had pronounced antibacterial and antifungal activities. Platinum (IV) complex had moderate antibacterial and antifungal activity. These values indicate that these are active compounds. Key words: Mixed Ligand; Transition metal; Antimicrobial Activity; Antifungal Activity Minimum Inhibitory Concentrations (MIC) DOI: http://dx.doi.org/10.3329/bjsir.v46i3.9044 BJSIR 2011; 46(3): 365-368

Mixed ligand complexes of coumarilic acid/nicotinamide with transition metal complexes

2013 ◽  
Vol 115 (2) ◽  
pp. 1515-1524 ◽  
Author(s):  
Dursun Ali Köse ◽  
Banu Öztürk ◽  
Onur Şahin ◽  
Orhan Büyükgüngör
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes

scholarly journals Antifungal activity of mixed ligand transition metal complexes of some dibasic acid and heterocyclic bases

1970 ◽  
Vol 4 (1) ◽  
pp. 57-59 ◽  
Author(s):  
Md Belayet Hossain ◽  
M Saidul Islam ◽  
Md Nazmul Hassan ◽  
MA Yousuf ◽  
M Abdus Salam
Keyword(s):  
Antifungal Activity ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Pathogenic Fungi ◽  
Mixed Ligand ◽  
Diffusion Method ◽  
Inhibition Of Growth ◽  
Diphenic Acid ◽  
Physical And Chemical

Mixed ligand transition metal complexes of Cu (II), Co (III), Rh (III) and Pt (IV) ions with dibasic acids viz., diphenic acid and adipic acid as primary ligands and amine bases as secondary ligands have been synthesized. Their conventional physical and chemical analyses have been done. The antifungal activities have been evaluated by Disc Diffusion method employed for antifungal assays against two pathogenic fungi. All the complexes show moderate antifungal activity. The highest inhibition of growth occurred on complex [Cu (DA)(8-HQ)] against the fungi Botryodiplodia theobromae and the lowest on complex [Rh (DA)(8-HQ)(H2 O)2] against the fungi Colletotrichum gloesparioides penz. Key words: Biological Activity, diphenic acid, heterocylic amine, mixed ligand complexes DOI: 10.3329/diujst.v4i1.4357 Daffodil International University Journal of Science and Technology Vol.4(1) 2009 pp.57-59

Antimicrobial and Toxicological Studies of Mixed Ligand Transition Metal Complexes of Schiff Bases

2002 ◽  
Vol 2 (12) ◽  
pp. 797-799 ◽  
Author(s):  
M. Saidul Islam . ◽  
M. Akhter Farooque . ◽  
M.A.K. Bodruddoza . ◽  
M. Ashik Mosaddik . ◽  
M. Shahidul Alam .
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Transition Metal Complexes ◽  
Mixed Ligand ◽  
Toxicological Studies
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