scholarly journals Synthesis of a photocurable acrylated poly(ethylene glycol)-co-poly(xylitol sebacate) copolymers hydrogel 3D printing ink for tissue engineering

RSC Advances ◽  
2019 ◽  
Vol 9 (32) ◽  
pp. 18394-18405 ◽  
Author(s):  
Yicai Wang ◽  
Yuan Li ◽  
Xiaoling Yu ◽  
Qizhi Long ◽  
Tian Zhang

A novel acrylated poly(ethylene glycol)-co-poly(xylitol sebacate) (PEXS-A) hydrogel for 3D printing ink and cell encapsulation for tissue engineering application.

Author(s):  
Audrey L. Earnshaw ◽  
Justine J. Roberts ◽  
Garret D. Nicodemus ◽  
Stephanie J. Bryant ◽  
Virginia L. Ferguson

Agarose and poly(ethylene-glycol) (PEG) are commonly used as scaffolds for cell and tissue engineering applications [1]. Agarose is a natural biomaterial that is thought to be inert [2] and permits growing cells and tissues in a three-dimensional suspension [3]. Gels synthesized from photoreactive poly(ethylene glycol) (PEG) macromonomers are well suited as cell carriers because they can be rapidly photopolymerized in vivo by a chain radical polymerization that is not toxic to cells, including chondrocytes. This paper explores the differences in mechanical behavior between agarose, a physically cross-linked hydrogel, and PEG, a chemically cross-linked hydrogel, to set the foundation for choosing hydrogel properties and chemistries for a desired tissue engineering application.


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