scholarly journals Evaluation of UV-crosslinked Poly(ethylene glycol) Diacrylate/Poly(dimethylsiloxane) Dimethacrylate Hydrogel: Properties for Tissue Engineering Application

2016 ◽  
Vol 19 ◽  
pp. 410-418 ◽  
Author(s):  
Z.A. Abdul Hamid ◽  
K.W. Lim
Keyword(s):  
Tissue Engineering ◽  
Ethylene Glycol ◽  
Engineering Application ◽  
Tissue Engineering Application ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Poly Ethylene

The Mechanical Behavior of Engineered Hydrogels

2009 ◽  
Author(s):  
Audrey L. Earnshaw ◽  
Justine J. Roberts ◽  
Garret D. Nicodemus ◽  
Stephanie J. Bryant ◽  
Virginia L. Ferguson
Keyword(s):  
Tissue Engineering ◽  
Ethylene Glycol ◽  
Mechanical Behavior ◽  
Three Dimensional ◽  
Engineering Application ◽  
Tissue Engineering Application ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
A Chain

Agarose and poly(ethylene-glycol) (PEG) are commonly used as scaffolds for cell and tissue engineering applications [1]. Agarose is a natural biomaterial that is thought to be inert [2] and permits growing cells and tissues in a three-dimensional suspension [3]. Gels synthesized from photoreactive poly(ethylene glycol) (PEG) macromonomers are well suited as cell carriers because they can be rapidly photopolymerized in vivo by a chain radical polymerization that is not toxic to cells, including chondrocytes. This paper explores the differences in mechanical behavior between agarose, a physically cross-linked hydrogel, and PEG, a chemically cross-linked hydrogel, to set the foundation for choosing hydrogel properties and chemistries for a desired tissue engineering application.

scholarly journals Synthesis of a photocurable acrylated poly(ethylene glycol)-co-poly(xylitol sebacate) copolymers hydrogel 3D printing ink for tissue engineering

RSC Advances ◽  
2019 ◽  
Vol 9 (32) ◽  
pp. 18394-18405 ◽  
Author(s):  
Yicai Wang ◽  
Yuan Li ◽  
Xiaoling Yu ◽  
Qizhi Long ◽  
Tian Zhang
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Ethylene Glycol ◽  
Engineering Application ◽  
Cell Encapsulation ◽  
Tissue Engineering Application ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Printing Ink

A novel acrylated poly(ethylene glycol)-co-poly(xylitol sebacate) (PEXS-A) hydrogel for 3D printing ink and cell encapsulation for tissue engineering application.

scholarly journals Controlling Fluid Diffusion and Release through Mixed-Molecular-Weight Poly(ethylene) Glycol Diacrylate (PEGDA) Hydrogels

Materials ◽  
2019 ◽  
Vol 12 (20) ◽  
pp. 3381 ◽  
Author(s):  
Kieran O’Donnell ◽  
Adrian Boyd ◽  
Brian J. Meenan
Keyword(s):  
Tissue Engineering ◽  
Molecular Weight ◽  
Ethylene Glycol ◽  
Mesh Size ◽  
Material Structure ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Fluorescence Measurements ◽  
Fluid Permeability ◽  
Poly Ethylene

Due to their inherent ability to swell in the presence of aqueous solutions, hydrogels offer a means for the delivery of therapeutic agents in a range of applications. In the context of designing functional tissue-engineering scaffolds, their role in providing for the diffusion of nutrients to cells is of specific interest. In particular, the facility to provide such nutrients over a prolonged period within the core of a 3D scaffold is a critical consideration for the prevention of cell death and associated tissue-scaffold failure. The work reported here seeks to address this issue via fabrication of hybrid 3D scaffolds with a component fabricated from mixed-molecular-weight hydrogel formulations capable of storing and releasing nutrient solutions over a predetermined time period. To this end, poly(ethylene) glycol diacrylate hydrogel blends comprising mixtures of PEGDA-575 Mw and PEGDA-2000 Mw were prepared via UV polymerization. The effects of addition of the higher-molecular-weight component and the associated photoinitiator concentration on mesh size and corresponding fluid permeability have been investigated by diffusion and release measurements using a Theophylline as an aqueous nutrient model solution. Fluid permeability across the hydrogel films has also been determined using a Rhodamine B solution and associated fluorescence measurements. The results indicate that addition of PEGDA-2000 Mw to PEGDA-575 Mw coupled with the use of a specific photoinitiator concentration provides a means to change mesh size in a hydrogel network while still retaining an overall microporous material structure. The range of mesh sizes created and their distribution in a 3D construct provides for the conditions required for a more prolonged nutrient release profile for tissue-engineering applications.

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