scholarly journals In vivo evaluation of the anti-obesity effects of combinations of Monascus pigment derivatives

RSC Advances ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 1456-1462 ◽  
Author(s):  
Deokyeong Choe ◽  
Hyun Ho Jung ◽  
Daehwan Kim ◽  
Chul Soo Shin ◽  
Tony Vaughn Johnston ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Monascus Pigment ◽  
Derivatives Of ◽  
Tryptophan Derivatives

The combination of threonine and tryptophan derivatives of Monascus pigment showed the high anti-obesity effect in mice.

scholarly journals Bornyl Derivatives of p-(Benzyloxy)Phenylpropionic Acid: In Vivo Evaluation of Antidiabetic Activity

2020 ◽  
Vol 13 (11) ◽  
pp. 404
Author(s):  
Sergey Kuranov ◽  
Olga Luzina ◽  
Mikhail Khvostov ◽  
Dmitriy Baev ◽  
Darya Kuznetsova ◽  
...  
Keyword(s):  
Computational Prediction ◽  
Tolerance Test ◽  
Antidiabetic Activity ◽  
Oral Glucose ◽  
In Vivo Evaluation ◽  
Phenylpropionic Acid ◽  
Biological Targets ◽  
Lipid Metabolism Disorders ◽  
Derivatives Of

A series of bornyl derivatives of p-(benzyloxy)phenylpropionic acid were prepared, and their hypoglycemic activities were examined by an oral glucose tolerance test in mice. The results of this test revealed two compounds, 1 and 3, that can reduce the blood level of glucose similarly to reference compound vildagliptin. Both compounds were tested in an experiment on mice with metabolic disorders: the C57BL/6Ay strain. Along with hypoglycemic properties, the two compounds showed different abilities to correct lipid metabolism disorders. In silico prediction revealed that the studied substances are most likely bifunctional multitarget hypoglycemic compounds whose mechanism of action is based on a pronounced reduction in insulin resistance and a strong incretin-mimetic effect. The difference in the size of effects of these compounds on biochemical parameters of blood in the experiment on C57BL/6Ay mice was in good agreement with the computational prediction of the priority ranking of biological targets for these compounds. These results indicate that bornyl derivatives of p-(benzyloxy)phenylpropionic acid have a good potential as new agents for diabetes mellitus treatment due to their hypoglycemic and lipid-normalizing properties.

Highly water-soluble derivatives of the anesthetic agent propofol: in vitro and in vivo evaluation of cyclic amino acid esters

2003 ◽  
Vol 20 (1) ◽  
pp. 17-26 ◽  
Author(s):  
Cosimo Altomare ◽  
Giuseppe Trapani ◽  
Andrea Latrofa ◽  
Mariangela Serra ◽  
Enrico Sanna ◽  
...  
Keyword(s):  
Amino Acid ◽  
Water Soluble ◽  
Anesthetic Agent ◽  
Amino Acid Esters ◽  
In Vivo Evaluation ◽  
Derivatives Of ◽  
Acid Esters

Synthesis, in vitro, and in vivo evaluation of phosphate ester derivatives of combretastatin A-4

2003 ◽  
Vol 13 (9) ◽  
pp. 1505-1508 ◽  
Author(s):  
Mallinath B. Hadimani ◽  
Jianyi Hua ◽  
M.Devan Jonklaas ◽  
Raymond J. Kessler ◽  
Yezhou Sheng ◽  
...  
Keyword(s):  
Phosphate Ester ◽  
In Vivo Evaluation ◽  
Derivatives Of

In vitro and in vivo evaluation of O-alkyl derivatives of tramadol

2008 ◽  
Vol 18 (5) ◽  
pp. 1674-1680 ◽  
Author(s):  
Liming Shao ◽  
Michael Hewitt ◽  
Thomas P. Jerussi ◽  
Frank Wu ◽  
Scott Malcolm ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Alkyl Derivatives ◽  
Derivatives Of

N-Carboxyalkyl derivatives of 3-hydroxy-4-pyridinones: synthesis, complexation with Fe(III), Al(III) and Ga(III) and in vivo evaluation

2002 ◽  
Vol 92 (1) ◽  
pp. 43-54 ◽  
Author(s):  
M.Amélia Santos ◽  
Marco Gil ◽  
Sérgio Marques ◽  
Lurdes Gano ◽  
Guilhermina Cantinho ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Derivatives Of

Derivatives of way 100635 as potential imaging agents for 5-ht1a receptors: syntheses, radiosyntheses, and in vitro and in vivo evaluation

1998 ◽  
Vol 25 (8) ◽  
pp. 769-776 ◽  
Author(s):  
Alan A. Wilson ◽  
Ted Inaba ◽  
Nancy Fischer ◽  
Lori M. Dixon ◽  
José Nobrega ◽  
...  
Keyword(s):  
Imaging Agents ◽  
In Vivo Evaluation ◽  
Way 100635 ◽  
Derivatives Of

scholarly journals In vitro and in vivo evaluation of C-20- and C-23-modified derivatives of tylosin against veterinary pathogens.

1988 ◽  
Vol 41 (7) ◽  
pp. 938-948 ◽  
Author(s):  
H. A. KIRST ◽  
E. E. OSE ◽  
J. E. TOTH ◽  
K. E. WILLARD ◽  
M. DEBONO ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
C 23 ◽  
Derivatives Of

Radiolabelling and in vivo evaluation of [11C]GSK215083 as potential PET radioligand for the 5-HT6 receptor in the porcine brain

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S598-S598 ◽  
Author(s):  
Laurent Martarello ◽  
Vincent J Cunningham ◽  
Julian C Matthews ◽  
Eugenii Rabiner ◽  
Steen Jakobsen ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Porcine Brain
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