scholarly journals The mineralization, drug release and in vivo bone defect repair properties of calcium phosphates/PLA modified tantalum scaffolds

RSC Advances ◽  
2020 ◽  
Vol 10 (13) ◽  
pp. 7708-7717 ◽  
Author(s):  
Rong Zhou ◽  
Hai-Jian Ni ◽  
Jin-Hui Peng ◽  
Ning Liu ◽  
Shu Chen ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Drug Release ◽  
Bone Defect ◽  
High Performance ◽  
Calcium Phosphates ◽  
Sustained Drug Release ◽  
Bone Defect Repair ◽  
Defect Repair

Calcium phosphate modified tantalum scaffolds displayed high performance on mineralization, sustained drug release and in vivo bone defect repair.

Preparation and characterization of calcium phosphate cement with enhanced tissue adhesion for bone defect repair

2021 ◽  
Vol 47 (2) ◽  
pp. 1712-1720
Author(s):  
Weibin Zhong ◽  
Lin Sun ◽  
Tao Yu ◽  
Changren Zhou
Keyword(s):  
Calcium Phosphate ◽  
Bone Defect ◽  
Calcium Phosphate Cement ◽  
Tissue Adhesion ◽  
Bone Defect Repair ◽  
Defect Repair

Effectiveness of Bone Morphogenetic Protein7 Transduced Bone Marrow Stromal Cells Combined with Hydrogel-Hydroxyapatite Composites on Bone Defect Repair In Vivo

2018 ◽  
Vol 8 (8) ◽  
pp. 1135-1141
Author(s):  
Yang Hou ◽  
Haibo Wang ◽  
Jian Kang ◽  
Lei Liang ◽  
Jingchuan Sun ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Defect ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Bone Defect Repair ◽  
Defect Repair

In vitro and in vivo properties of graphene-incorporated scaffolds for bone defect repair

2021 ◽  
Author(s):  
Hossein Jodati ◽  
Bengi Yilmaz ◽  
Zafer Evis
Keyword(s):  
Bone Defect ◽  
Bone Defect Repair ◽  
Defect Repair

scholarly journals The immunogenic reaction and bone defect repair function of ε-poly-L-lysine (EPL)-coated nanoscale PCL/HA scaffold in rabbit calvarial bone defect

2021 ◽  
Vol 32 (6) ◽  
Author(s):  
Bin Tian ◽  
Na Wang ◽  
Qingsong Jiang ◽  
Lijiao Tian ◽  
Lei Hu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Defect ◽  
Macrophage Infiltration ◽  
T Helper ◽  
Calvarial Bone ◽  
Bone Defect Repair ◽  
Defect Repair ◽  
Calvarial Bone Defect ◽  
Helper Type

AbstractTissue engineering is a promising strategy for bone tissue defect reconstruction. Immunogenic reaction, which was induced by scaffolds degradation or contaminating microorganism, influence cellular activity, compromise the efficiency of tissue engineering, or eventually lead to the failure of regeneration. Inhibiting excessive immune response through modulating scaffold is critical important to promote tissue regeneration. Our previous study showed that ε-poly-L-lysine (EPL)-coated nanoscale polycaprolactone/hydroxyapatite (EPL/PCL/HA) composite scaffold has enhanced antibacterial and osteogenic properties in vitro. However, the bone defect repair function and immunogenic reaction of EPL/PCL/HA scaffolds in vivo remains unclear. In the present study, three nanoscale scaffolds (EPL/PCL/HA, PCL and PCL/HA) were transplanted into rabbit paraspinal muscle pouches, and T helper type 1 (Th1), T helper type 2 (Th2), T helper type 17 (Th17), and macrophage infiltration were analyzed after 1 week and 2 weeks to detect their immunogenic reaction. Then, the different scaffolds were transplanted into rabbit calvarial bone defect to compare the bone defect repair capacities. The results showed that EPL/PCL/HA composite scaffolds decreased pro-inflammatory Th1, Th17, and type I macrophage infiltration from 1 to 2 weeks, and increased anti-inflammatory Th2 infiltration into the regenerated area at 2 weeks in vivo, when compared to PCL and PCL/HA. In addition, EPL/PCL/HA showed an enhanced bone repair capacity compared to PCL and PCL/HA when transplanted into rabbit calvarial bone defects at both 4 and 8 weeks. Hence, our results suggest that EPL could regulate the immunogenic reaction and promote bone defect repair function of PCL/HA, which is a promising agent for tissue engineering scaffold modulation.

scholarly journals In Vivo and in Vitro Studies of the Effect of Chitosan on the Bone Defect Repair Process

2016 ◽  
Vol 16 (2) ◽  
pp. 171-179 ◽  
Author(s):  
I. V. Zudina ◽  
◽  
A. P. Vedyaeva ◽  
P. V. Ivanov ◽  
A. F. A. Alzubaidi ◽  
...  
Keyword(s):  
Bone Defect ◽  
Repair Process ◽  
In Vitro Studies ◽  
Bone Defect Repair ◽  
Defect Repair
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